Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Impact of Dexmedetomidine on the Post-Operative Cognition Dysfunction(POCD) in Geriatric Patients

First Posted Date
2014-10-27
Last Posted Date
2018-04-25
Lead Sponsor
The First Affiliated Hospital of Anhui Medical University
Target Recruit Count
864
Registration Number
NCT02275182
Locations
🇨🇳

Affiliated Chaohu Hospital of Anhui Medical Hospital, Chaohu, Anhui, China

🇨🇳

Binhu Hospital of Hefei, Hefei, Anhui, China

🇨🇳

The first Hospital of Hefei, Hefei, Anhui, China

and more 10 locations

Reduction in MACbar of Sevoflurane by Dexmedetomidine in Children

Not Applicable
Completed
Conditions
Children
Interventions
Drug: dexmedetomidine
First Posted Date
2014-10-10
Last Posted Date
2014-10-10
Lead Sponsor
Cai Li
Target Recruit Count
63
Registration Number
NCT02261675

Dexmedetomidine vs Propofol on the Recordings of Deep Brain Activity Measured Through Implanted Stimulators

Phase 4
Completed
Conditions
Parkinson's Disease
Interventions
Drug: Dexmedetomidine
Drug: Propofol
First Posted Date
2014-10-03
Last Posted Date
2015-12-18
Lead Sponsor
Clinica Universidad de Navarra, Universidad de Navarra
Target Recruit Count
12
Registration Number
NCT02256319
Locations
🇪🇸

University of Navarra Clinic, Pamplona, Navarra, Spain

Dexmedetomidine-based Sedation in Neurocritical Care Patients

Phase 2
Conditions
Acute Brain Injuries
Interventions
Drug: Dexmedetomidine
First Posted Date
2014-09-30
Last Posted Date
2014-09-30
Lead Sponsor
University Hospital, Clermont-Ferrand
Target Recruit Count
66
Registration Number
NCT02252523
Locations
🇫🇷

CHU Clermont-Ferrand, Clermont-Ferrand, France

A Comparison of Two Sedation Techniques in Children Undergoing Transthoracic Echocardiography (TTE)

First Posted Date
2014-09-26
Last Posted Date
2020-01-21
Lead Sponsor
Children's Hospital Medical Center, Cincinnati
Target Recruit Count
280
Registration Number
NCT02250820
Locations
🇺🇸

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

Intranasal Dexmedetomidine Premedication in Children

Phase 3
Completed
Conditions
Preoperative Sedation
Interventions
Drug: Midazolam
Drug: Dexmedetomidine
First Posted Date
2014-09-26
Last Posted Date
2017-07-07
Lead Sponsor
University of Mississippi Medical Center
Target Recruit Count
75
Registration Number
NCT02250703
Locations
🇺🇸

Children's of Mississippi/University of Mississipi Medical Center, Jackson, Mississippi, United States

Consequence of Dexmedetomidine on Emergence Deliruim After Sevoflurane Anesthesia in Children With Cerebral Palsy

First Posted Date
2014-09-19
Last Posted Date
2014-09-19
Lead Sponsor
Jin Ni
Target Recruit Count
80
Registration Number
NCT02244515

Efficacy of Low-dose Dexmedetomidine to Prevent Delirium in Liver Transplant Patients

Phase 4
Completed
Conditions
Liver Transplantation
Interventions
Drug: placebo control
Drug: Precedex
First Posted Date
2014-09-19
Last Posted Date
2019-09-25
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
217
Registration Number
NCT02245256
Locations
🇰🇷

Seoul National University Hospital, Seoul, Agree, Korea, Republic of

Dexmedetomidine and Outcomes of Cardiac Surgery (DOCS)

First Posted Date
2014-09-11
Last Posted Date
2020-07-08
Lead Sponsor
Xijing Hospital
Target Recruit Count
1100
Registration Number
NCT02237495
Locations
🇨🇳

Xijing Hospital, Xi'an, Shaanxi, China

Effects of Dexmedetomidine Sedation on Delirium and Haemodynamic in Mechanical Ventilated Elderly Patients

First Posted Date
2014-08-26
Last Posted Date
2014-08-26
Lead Sponsor
Fuling Central Hospital of Chongqing City
Target Recruit Count
80
Registration Number
NCT02225210
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