Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Adjuvant Effect of Dexmedetomidine in Ultrasound (USG) Guided Transvers Abdominis Plane Block

Phase 3

Withdrawn

Conditions: Postoperative Nausea and Vomiting

Interventions: Drug: 0.25 % bupivacaine
Drug: Dexmedetomidine

First Posted Date: 2015-01-06

Last Posted Date: 2015-09-04

Lead Sponsor: Kırıkkale University

Registration Number: NCT02331563

Locations: 🇹🇷
Kırıkkale University School of Medicine Department of Anaesthesiology and Reanimation, Kırıkkale, Yahşihan, Turkey

Effects of Dexmedetomidine and Propofol on Pulmonary Mechanics

Phase 4

Completed

Conditions: Abnormal Respiratory Airway Resistance

Interventions: Drug: dexmedetomidine
Drug: propofol

First Posted Date: 2015-01-01

Last Posted Date: 2015-12-10

Lead Sponsor: Cukurova University

Target Recruit Count: 64

Registration Number: NCT02330120

Locations: 🇹🇷
Cukurova University, Adana, Turkey

Dexmedetomidine as an Adjuvant for Sub-Tenon's Anesthesia

Phase 3

Completed

Conditions: Vitreoretinal Surgery Under Sub-Tenon's Anesthesia

Interventions: Drug: dexmedetomidine

First Posted Date: 2014-12-30

Last Posted Date: 2014-12-30

Lead Sponsor: Magrabi Eye & Ear Hospital

Target Recruit Count: 60

Registration Number: NCT02327156

The Postoperative Analgesic Effect of Combination With Dexmedetomidine in Fentanyl-based Intravenous Patient Controlled Analgesia Compared With Conventional Thoracic Epidural and Intravenous Patient Controlled Analgesia After Radical Open Gastrectomy

Not Applicable

Completed

Conditions: Postoperative Pain

Interventions: Drug: Fentanyl 1
Drug: Fentanyl 2
Drug: Dexmedetomidine

First Posted Date: 2014-12-25

Last Posted Date: 2016-03-29

Lead Sponsor: Yonsei University

Target Recruit Count: 171

Registration Number: NCT02325882

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine, Seoul, Korea, Republic of