Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Sedation During Bronchoscopy:Dexmedetomidine vs Alfentanil

Phase 3

Completed

Conditions: Bronchoscopy
Conscious Sedation

Interventions: Drug: xylocain
Drug: Alfentanil
Drug: Dexmedetomidine

First Posted Date: 2013-03-06

Last Posted Date: 2014-11-25

Lead Sponsor: Saint-Joseph University

Target Recruit Count: 162

Registration Number: NCT01805726

Locations: 🇱🇧
Hotel Dieu de France Hospital, Beirut, Lebanon

Does Nightly Dexmedetomidine Improve Sleep and Reduce Delirium in ICU Patients?

Phase 4

Completed

Conditions: Sleep Deprivation
Delirium

Interventions: Other: Placebo
Drug: Dexmedetomidine

First Posted Date: 2013-02-13

Last Posted Date: 2017-03-17

Lead Sponsor: Maisonneuve-Rosemont Hospital

Target Recruit Count: 100

Registration Number: NCT01791296

Locations: 🇨🇦
Maisonneuve Rosemont Hospital, Montréal, Quebec, Canada
🇺🇸
Tufts Medical Center, Boston, Massachusetts, United States

Anesthesia for Deep Brain Stimulation

Phase 4

Completed

Conditions: Parkinsons Disease

Interventions: Drug: Dexmedetomidine

First Posted Date: 2013-02-12

Last Posted Date: 2014-05-20

Lead Sponsor: Diskapi Teaching and Research Hospital

Target Recruit Count: 26

Registration Number: NCT01789385

Locations: 🇹🇷
Ankara Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey

Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy

Phase 4

Completed

Conditions: Coughing

Interventions: Drug: Saline
Drug: Dexmedetomidine

First Posted Date: 2013-01-23

Last Posted Date: 2014-02-10

Lead Sponsor: Yonsei University

Target Recruit Count: 141

Registration Number: NCT01774305

Locations: 🇰🇷
Gangnam severance hospital, Seoul, Korea, Republic of

Dexmedetomidine vs. Remifentanil for Pre-eclampsia During Caesarean Delivery

Phase 2

Completed

Conditions: Severe Pre-eclampsia
Pregnancy

Interventions: Drug: Dexmedetomidine
Drug: Remifentanil

First Posted Date: 2013-01-11

Last Posted Date: 2017-01-23

Lead Sponsor: Mansoura University

Target Recruit Count: 50

Registration Number: NCT01766089

Locations: 🇪🇬
Mansoura University Hospitals, Mansoura, DK, Egypt

Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial

Phase 4

Completed

Conditions: Sepsis

Interventions: Drug: Dexmedetomidine

First Posted Date: 2013-01-04

Last Posted Date: 2017-02-28

Lead Sponsor: Wakayama Medical University

Target Recruit Count: 203

Registration Number: NCT01760967

Locations: 🇯🇵
Tohoku University, Sendai, Miyagi, Japan

Effects of Dexmedetomidine on the Postoperative Experience in Children

Phase 4

Completed

Conditions: Failed Moderate Sedation During Procedure

Interventions: Drug: dexmedetomidine
Drug: Midazolam
Drug: fentanyl

First Posted Date: 2012-12-12

Last Posted Date: 2012-12-12

Lead Sponsor: Inonu University

Target Recruit Count: 42

Registration Number: NCT01748630

Locations: 🇹🇷
Inonu University Turgut Ozal Medical Center, Malatya, Turkey

The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure

Phase 3

Completed

Conditions: Sepsis
Delirium
Impaired Cognition

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2012-12-04

Last Posted Date: 2021-06-07

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 438

Registration Number: NCT01739933

Locations: 🇺🇸
Baystate Medical Center, Springfield, Massachusetts, United States
🇺🇸
Mission Hospital, Asheville, North Carolina, United States
🇺🇸
Baton Rouge General Medical Center and Our Lady of The Lakes Regional Medical Center, Baton Rouge, Louisiana, United States

and more 8 locations