Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Comparison Between Remifentanil Target-controlled Infusion and Dexmedetomidine Bolus Administration for Smooth Emergence From General Sevoflurane Anesthesia

Not Applicable
Completed
Conditions
Thyroid Neoplasm
Interventions
Drug: dexmedetomidine
Drug: Normal Saline
First Posted Date
2012-06-12
Last Posted Date
2012-06-12
Lead Sponsor
Yonsei University
Target Recruit Count
65
Registration Number
NCT01617694
Locations
🇰🇷

Severance hospital, Seoul, Korea, Republic of

Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients

Phase 1
Completed
Conditions
Acute Respiratory Failure
Anxiety
Interventions
Drug: Dexmedetomidine
First Posted Date
2012-05-28
Last Posted Date
2018-03-13
Lead Sponsor
University of Minnesota
Target Recruit Count
15
Registration Number
NCT01606852
Locations
🇺🇸

University of Minnesota Medical Center, Minneapolis, Minnesota, United States

The Effect of Dexmedetomidine on Emergence Agitation in Children Undergoing a Surgery Under Desflurane Anesthesia

First Posted Date
2012-04-16
Last Posted Date
2012-04-16
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
116
Registration Number
NCT01578161
Locations
🇰🇷

Department of Anesthesiology and Pain Medicine, SEOUL NATIONAL UNIVERSITY BUNDANG HOSPITAL, SungNam-si, Kyonggi do, Korea, Republic of

The Effect of Dexmedetomidine in the Management of Pain After Uterine Artery Embolization

Not Applicable
Completed
Conditions
Pain Control
Interventions
Drug: Normal saline 0.9%
Drug: Dexmedetomidine
First Posted Date
2012-04-16
Last Posted Date
2018-01-17
Lead Sponsor
Severance Hospital
Target Recruit Count
66
Registration Number
NCT01578174
Locations
🇰🇷

Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of

Effects of Dexmedetomidine on Inflammatory Cytokines in Patients With Aneurysmal Subarachnoid Hemorrhage

First Posted Date
2012-03-28
Last Posted Date
2018-02-01
Lead Sponsor
University of Cincinnati
Target Recruit Count
4
Registration Number
NCT01565590
Locations
🇺🇸

University Hospital, Cincinnati, Ohio, United States

Efficacy and Safety Study of Dexmedetomidine as an Additive to Local Anesthetics in Shoulder Surgery

Phase 3
Completed
Conditions
Drug Safety
Self Efficacy
Interventions
Drug: dexmedetomidine
Drug: saline
First Posted Date
2012-03-19
Last Posted Date
2012-12-04
Lead Sponsor
Prof. Peter Gerner, M.D.
Target Recruit Count
62
Registration Number
NCT01557270
Locations
🇦🇹

Paracelsus Medical University, Department of Anesthesiology, Perioperative and Intensive Care Medicine, Salzburg, Austria

Effects of a Dexmedetomidine on Quality of Recovery 40 and Postoperative Nausea and Vomiting in Breast Cancer Surgery

Not Applicable
Completed
Conditions
Breast Cancer
Interventions
Drug: Placebo
Drug: Dexmedetomidine
First Posted Date
2012-03-08
Last Posted Date
2015-02-02
Lead Sponsor
Yonsei University
Target Recruit Count
97
Registration Number
NCT01548209
Locations
🇰🇷

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 250 Seungsan-no, Seodaemun-gu, Seoul, Korea, Republic of

Comparison of Dexmedetomidine and Propofol-Remifentanil Conscious Sedation for Awake Craniotomy for Tumor Surgery

Not Applicable
Completed
Conditions
Brain Tumor
Interventions
Drug: Dexmedetomidine
Drug: Propofol
Drug: Remifentanil
First Posted Date
2012-03-06
Last Posted Date
2016-07-07
Lead Sponsor
Nicolai Goettel
Target Recruit Count
50
Registration Number
NCT01545297
Locations
🇨🇦

UHN Toronto Western Hospital, Toronto, Ontario, Canada

Effect of Dexmedetomidine on Emergence Agitation in Children With or Without Tube Insertion Under General Anesthesia

Phase 4
Completed
Conditions
Myringotomy
Interventions
Drug: Dexmedetomidine
First Posted Date
2012-02-17
Last Posted Date
2018-07-09
Lead Sponsor
Martin Mueller
Target Recruit Count
140
Registration Number
NCT01535287
Locations
🇺🇸

University of Iowa Hospital and Clinics, Iowa City, Iowa, United States

Dexmedetomidine as a Rapid Bolus in Children for Emergence Agitation

Phase 3
Completed
Conditions
Tonsillectomy
Interventions
Other: Placebo
Drug: Dexmedetomidine
First Posted Date
2012-02-08
Last Posted Date
2018-03-08
Lead Sponsor
Peter Davis
Target Recruit Count
418
Registration Number
NCT01528891
Locations
🇺🇸

Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States

🇺🇸

Childrens Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States

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