Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Effect of Single-dose Dexmedetomidine on Emergence Excitement in Adults With Nasotracheal Intubation After Orthognathic Surgery

Phase 4

Completed

Conditions: Agitation

Interventions: Drug: saline
Drug: Dexmedetomidine

First Posted Date: 2012-02-02

Last Posted Date: 2015-02-06

Lead Sponsor: Yonsei University

Target Recruit Count: 74

Registration Number: NCT01524367

Locations: 🇰🇷
Gangnam severance hospital, Seoul, Korea, Republic of

Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Subjects Undergoing Procedure-Type Sedation

Phase 4

Completed

Conditions: Ultrasound
MRIs
CT Scans

Interventions: Drug: Dexmedetomidine
Drug: Midazolam
Drug: Fentanyl

First Posted Date: 2012-01-26

Last Posted Date: 2017-03-20

Lead Sponsor: Hospira, now a wholly owned subsidiary of Pfizer

Target Recruit Count: 91

Registration Number: NCT01519167

Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia

Phase 4

Completed

Conditions: Restlessness
Pain

Interventions: Drug: dexmedetomidine
Drug: saline placebo

First Posted Date: 2012-01-25

Last Posted Date: 2013-03-20

Lead Sponsor: Fang Luo

Target Recruit Count: 60

Registration Number: NCT01517932

The Effect of Dexmedetomidine on the Emergence Agitation in Nasal Surgery

Not Applicable

Completed

Conditions: Airway Extubation

Interventions: Drug: Normal saline 0.9%
Drug: Dexmedetomidine

First Posted Date: 2012-01-20

Last Posted Date: 2012-08-09

Lead Sponsor: Severance Hospital

Target Recruit Count: 100

Registration Number: NCT01513772

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of