Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Use of Dexmedetomidine in Children Undergoing Oral Maxillofacial Surgery to Decrease Emergence Delirium

Phase 4

Withdrawn

Conditions: Delirium

Interventions: Drug: dexmedetomidine

First Posted Date: 2011-05-13

Last Posted Date: 2017-05-05

Lead Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Registration Number: NCT01353378

Locations: 🇨🇳
Shanghai Ninth People's Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, Shanghai, China

Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea

Phase 4

Completed

Conditions: Sleep Apnea, Obstructive

Interventions: Drug: Propofol
Drug: Dexmedetomidine

First Posted Date: 2011-04-29

Last Posted Date: 2018-08-08

Lead Sponsor: Children's Hospital Medical Center, Cincinnati

Target Recruit Count: 60

Registration Number: NCT01344759

Locations: 🇺🇸
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

Providing "Good Sleep" for ICU Sedation

Not Applicable

Completed

Conditions: Sleep Disorders

Interventions: Other: Normal saline infusion
Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2011-04-27

Last Posted Date: 2018-12-19

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 3

Registration Number: NCT01342328

Locations: 🇺🇸
University of California San Francisco, San Francisco, California, United States

Dexmedetomidine Pharmacokinetics During Continuous Renal Replacement Therapy (CRRT)

Phase 2

Conditions: Acute Kidney Injury

Interventions: Drug: Dexmedetomidine

First Posted Date: 2011-03-14

Last Posted Date: 2012-10-24

Lead Sponsor: Helsinki University Central Hospital

Target Recruit Count: 10

Registration Number: NCT01314209

Locations: 🇫🇮
Meilahti Hospital, Division of Anaesthesia and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland

The Effect of Dexmedetomidine on Hemodynamic Response During Double Lumen Endotracheal Intubation

Phase 2

Completed

Conditions: Intubation Complication
Tracheal Intubation Morbidity
Anesthesia Intubation Complication
Hypertension
High Blood Pressure
Tachycardia

Interventions: Drug: Dexmedetomidine
Drug: Placebo

First Posted Date: 2011-02-04

Last Posted Date: 2011-12-15

Lead Sponsor: Chiang Mai University

Target Recruit Count: 60

Registration Number: NCT01289769

Locations: 🇹🇭
Chiang Mai University Hospital, Maung, Chiang Mai, Thailand

Dexmedetomidine on Postoperative Delirium and Quality of Recovery in Geriatric Patients

Phase 3

Conditions: Delirium, Postoperative

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2011-01-26

Last Posted Date: 2013-11-20

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 500

Registration Number: NCT01283412

Locations: 🇨🇳
Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China