Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Effects of Dexmedetomidine on Activity in the Subthalamic Nucleus

Phase 4

Completed

Conditions: Parkinson's Disease
Deep Brain Stimulation Surgery

Interventions: Drug: Dexmedetomidine

First Posted Date: 2012-11-04

Last Posted Date: 2017-12-08

Lead Sponsor: University of Wisconsin, Madison

Target Recruit Count: 6

Registration Number: NCT01721460

Locations: 🇺🇸
University of Wisconsin - Madison, School of Medicine and Public Health, Madison, Wisconsin, United States

Dexmedetomidine's Cardiac and Cognitive Influence on Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery

Conditions: Coronary Artery Disease

Interventions: Drug: Dexmedetomidine

First Posted Date: 2012-10-11

Last Posted Date: 2012-10-30

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 90

Registration Number: NCT01704092

Locations: 🇨🇳
Department of Anesthesiology ,Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei, China

The Effect of Dexmedetomidine of the Immune System

Completed

Conditions: Breast Cancer

Interventions: Drug: Dexmedetomidine

First Posted Date: 2012-09-25

Last Posted Date: 2016-01-07

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 20

Registration Number: NCT01692210

Locations: 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery

Not Applicable

Completed

Conditions: Ambulation Difficulty

Interventions: Drug: normal saline
Drug: Dexmedetomidine

First Posted Date: 2012-09-24

Last Posted Date: 2012-09-24

Lead Sponsor: Yonsei University

Target Recruit Count: 40

Registration Number: NCT01691001

Locations: 🇰🇷
Severance Hospital, Seoul, Korea, Republic of

Evaluation of Efficacy and Safety of General Anesthesia Using Dexmedetomidine With Sevoflurane in Patients Undergoing Arthroscopic Shoulder Surgery: Preliminary Study

Not Applicable

Completed

Conditions: Arthroscopic Shoulder Surgery in the Beach-chair Position

Interventions: Drug: Dexmedetomidine

First Posted Date: 2012-09-19

Last Posted Date: 2014-03-05

Lead Sponsor: Yonsei University

Target Recruit Count: 19

Registration Number: NCT01687868

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine,Yonsei University Health System, Seoul, Korea, Republic of

Pilot Study Comparing Treatment With Dexmedetomidine to Midazolam for Symptom Control in Advanced Cancer Patients

Phase 2

Withdrawn

Conditions: Nausea
Delirium
Pain Intractable
Dyspnea

Interventions: Drug: Dexmedetomidine
Drug: Midazolam

First Posted Date: 2012-09-19

Last Posted Date: 2015-05-25

Lead Sponsor: Fraser Health

Registration Number: NCT01687751

Locations: 🇨🇦
Abbotsford Regional Hospital and Cancer Center, Abbotsford, British Columbia, Canada

Comparison the Hemodynamics Effects Between Dexmedetomidine and Propofol in Major Abdominal Surgical Patients

Conditions: Abdominal Tumor
Intestinal Obstruction
Cirrhosis
Intestinal Fistula
Aneurism

Interventions: Drug: dexmedetomidine
Drug: propofol

First Posted Date: 2012-08-20

Last Posted Date: 2012-08-22

Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Target Recruit Count: 80

Registration Number: NCT01669044

Locations: 🇨🇳
First affiliated hostipal,Sun Yat-sen University, Guangzhou, Guangdong, China

Effective Dose of Dexmedetomidine for Sedation in Patients Undergoing TURP/TURB Under Spinal Anesthesia With or Without Fentanyl by Age Groups: Randomized Comparative Study

Not Applicable

Completed

Conditions: Benign Prostate Hyperplasia
Bladder Tumor

Interventions: Drug: dexmedetomidine

First Posted Date: 2012-08-15

Last Posted Date: 2014-07-28

Lead Sponsor: Yonsei University

Target Recruit Count: 82

Registration Number: NCT01665586

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine, and Anesthesia and Pain Research Institute, Seoul, Korea, Republic of

A Comparison of Dexmedetomidine and Epidural Anesthesia Under General Anesthesia in Patients Undergoing Gastrectomy

Phase 4

Conditions: Gastrectomy

Interventions: Drug: dexmedetomidine

First Posted Date: 2012-08-06

Last Posted Date: 2012-08-06

Lead Sponsor: Anhui Medical University

Target Recruit Count: 90

Registration Number: NCT01657812

Locations: 🇨🇳
The Second Affiliated Hospital of Anhui Medical University, HeFei, Anhui, China

Sedation During Muscle Biopsy in Patients With Duchenne Muscular Dystrophy

Not Applicable

Completed

Conditions: Duchenne Muscular Dystrophy

Interventions: Drug: Ketamine
Drug: Dexmedetomidine

First Posted Date: 2012-07-20

Last Posted Date: 2015-02-26

Lead Sponsor: Nationwide Children's Hospital

Target Recruit Count: 53

Registration Number: NCT01645098

Locations: 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States

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