Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Pilot Study of Liposomal Bupivacaine Redosing in Patients Undergoing Major Gynecologic Procedures
- Conditions
- Interventions
- First Posted Date
- 2021-04-19
- Last Posted Date
- 2024-08-23
- Lead Sponsor
- University of California, Irvine
- Target Recruit Count
- 13
- Registration Number
- NCT04849858
- Locations
- 🇺🇸
University of California, Irvine, Orange, California, United States
Bupivacaine in Tonsillectomy
- First Posted Date
- 2021-04-01
- Last Posted Date
- 2023-08-04
- Lead Sponsor
- Nordlandssykehuset HF
- Target Recruit Count
- 84
- Registration Number
- NCT04825704
- Locations
- 🇳🇴
Nordland Hospital, Bodø, Norway
Opioid Reduction Initiative During Outpatient Pediatric Urologic Procedures Using Exparel
- Conditions
- Interventions
- First Posted Date
- 2021-04-01
- Last Posted Date
- 2023-12-26
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 104
- Registration Number
- NCT04826484
- Locations
- 🇺🇸
Johns Hopkins Hospital, Baltimore, Maryland, United States
Optimal Bupivacaine Dose for Initiation of Labor Epidural Techniques
- First Posted Date
- 2021-03-24
- Last Posted Date
- 2022-08-04
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT04814537
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Dexamethasone Plus Bupivacaine Versus Bupivacaine in Bilateral Trans-incisional Paravertebral Block in Lumbar Spine Surgeries .
- Conditions
- Interventions
- First Posted Date
- 2021-03-05
- Last Posted Date
- 2022-12-21
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 50
- Registration Number
- NCT04783194
- Locations
- 🇪🇬
Ain Shams University hospitals, Cairo, Egypt
Effectiveness of Combined Erector Spinae and Pecto-intercostal Fascial Plane Blocks Versus Thoracic Paravertebral Block in Perioperative Pain in Modified Radical Mastectomy
- Conditions
- Interventions
- First Posted Date
- 2021-03-03
- Last Posted Date
- 2023-03-13
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT04778267
- Locations
- 🇪🇬
Kase Al Aini teaching hospital, Cairo, Kasr Al Aini, Egypt
PROUD Study - Preventing Opioid Use Disorders
- Conditions
- Interventions
- Behavioral: Guided mindfulness exercisesOther: Self-administered aromatherapyDrug: Baby aspirinDrug: Tylenol/AcetaminophenDrug: PregabalinDrug: PrednisoneDrug: MeloxicamDrug: PrilosecDrug: TramadolDrug: VoltarenDrug: ZofranDrug: PepcidDrug: ReglanDrug: VersedDrug: LidocaineDrug: PropofolDrug: AncefDrug: Tranexamic Acid (TXA)Drug: DecadronDrug: Bupivacaine hydrochlorideDrug: Toradol
- First Posted Date
- 2021-02-23
- Last Posted Date
- 2023-06-22
- Lead Sponsor
- Emory University
- Target Recruit Count
- 57
- Registration Number
- NCT04766996
- Locations
- 🇺🇸
Emory University Orthopaedic and Spine Hospital, Atlanta, Georgia, United States
Evaluation of Exparel Adductor Canal Field Block for Pain Control After ACL Reconstruction
- Conditions
- Interventions
- First Posted Date
- 2021-02-21
- Last Posted Date
- 2021-02-21
- Lead Sponsor
- Carilion Clinic
- Target Recruit Count
- 60
- Registration Number
- NCT04764916
- Locations
- 🇺🇸
Carilion Clinic Institute for Orthopaedics and Neurosciences, Roanoke, Virginia, United States
Liposomal Bupivacaine Versus Bupivacaine Plain for Operative Pain Management of Forefoot Surgery
- Conditions
- Interventions
- First Posted Date
- 2021-02-12
- Last Posted Date
- 2021-02-25
- Lead Sponsor
- Alexandra Black
- Target Recruit Count
- 100
- Registration Number
- NCT04751344
- Locations
- 🇺🇸
Manhattan Eyes Ears and Throat Hospital, New York, New York, United States
Peripheral Nerve Injections for CRPS
- Conditions
- Interventions
- First Posted Date
- 2021-02-09
- Last Posted Date
- 2024-05-20
- Lead Sponsor
- Ottawa Hospital Research Institute
- Target Recruit Count
- 50
- Registration Number
- NCT04744675
- Locations
- 🇨🇦
The Ottawa Hospital, Ottawa, Ontario, Canada
🇨🇦Elisabeth Bruyere Hospital, Ottawa, Ontario, Canada
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.