Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery
- Conditions
- Interventions
- First Posted Date
- 2016-11-08
- Last Posted Date
- 2017-03-20
- Target Recruit Count
- 80
- Registration Number
- NCT02958566
- Locations
- 🇺🇸
Uicomp, Peoria, Illinois, United States
Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia
- Conditions
- Interventions
- Drug: Fentanyl HydrochlorideDrug: dexter ketamineDrug: Lidocaine HydrochlorideDrug: Clonidine HydrochlorideDrug: Midazolam HydrochlorideDrug: Isoflurane Volatile LiquidDrug: Propofol 1 % Injectable SuspensionDrug: Rocuronium Injectable SolutionDrug: Ranitidine HydrochlorideDrug: Dexamethasone-21-Sulfobenzoate, Sodium SaltDrug: Ondansetron HydrochlorideDrug: Ketorolac Injectable SolutionDrug: Bupivacaine Hydrochloride
- First Posted Date
- 2016-11-02
- Last Posted Date
- 2016-11-04
- Lead Sponsor
- Federal University of São Paulo
- Target Recruit Count
- 40
- Registration Number
- NCT02953210
- Locations
- 🇧🇷
Faculdade de Ciências Médicas da Santa Casa de São Paulo, Sao Paulo, Brazil
Intra-articular Local Anesthetic Injection and Hematoma Aspiration
- First Posted Date
- 2016-11-01
- Last Posted Date
- 2018-08-17
- Lead Sponsor
- Loyola University
- Target Recruit Count
- 2
- Registration Number
- NCT02951884
- Locations
- 🇺🇸
Loyola University Medical Center, Maywood, Illinois, United States
Ropivacaine Versus Bupivacaine as Preemptive Analgesia in Surgical Site in Ankle Fracture Patients
- Conditions
- Interventions
- First Posted Date
- 2016-10-31
- Last Posted Date
- 2018-12-31
- Lead Sponsor
- Instituto Mexicano del Seguro Social
- Target Recruit Count
- 93
- Registration Number
- NCT02949674
- Locations
- 🇲🇽
UMAE Dr. Victorio de La Fuente Narvaez, Ciudad de Mexico, Mexico
Hip Arthroscopy Pain Control Randomized Control Trial (RCT)
- First Posted Date
- 2016-10-27
- Last Posted Date
- 2018-01-10
- Lead Sponsor
- Walter Reed National Military Medical Center
- Target Recruit Count
- 74
- Registration Number
- NCT02947178
- Locations
- 🇺🇸
Walter Reed National Military Medical Center, Bethesda, Maryland, United States
Serratus Plane Block For Breast Reduction Surgery
- First Posted Date
- 2016-10-12
- Last Posted Date
- 2017-01-24
- Lead Sponsor
- Ataturk University
- Target Recruit Count
- 40
- Registration Number
- NCT02930733
- Locations
- 🇹🇷
Ataturk University, Erzurum, Turkey
TAP Block With Magnesium Sulfate Added to Local Anesthetic in Abdominal Hysterectomy
- First Posted Date
- 2016-10-12
- Last Posted Date
- 2016-10-12
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT02930707
Effect of Wound Infiltration by Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical Stress
- Conditions
- Interventions
- First Posted Date
- 2016-10-07
- Last Posted Date
- 2018-01-09
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 90
- Registration Number
- NCT02927379
- Locations
- 🇪🇬
South Egypt Cancer Instuite, Assuit, Egypt
Comparing Ropivacaine and Bupivacaine in DTFNB Anesthesia in Patients Undergoing Phacoemulsification
- Conditions
- Interventions
- First Posted Date
- 2016-10-06
- Last Posted Date
- 2017-01-25
- Lead Sponsor
- Government Medical College, Haldwani
- Target Recruit Count
- 100
- Registration Number
- NCT02925832
- Locations
- 🇮🇳
Government medical college, Haldwani, Uttarakhand, India
Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery
- Conditions
- Interventions
- First Posted Date
- 2016-10-05
- Last Posted Date
- 2017-09-07
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT02923869
- Locations
- 🇪🇬
Assiut university hospital, Assiut, Egypt
Drug Development Updates
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