Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
- -
The Effect of Paravertebral Block With Dexamethasone on Intraoperative and Postoperative Analgesia in Children Undergoing Surgery for Coarctation of Aorta
- Conditions
- Coarctation of Aorta
- Interventions
- Device: ultrasoundDrug: DexamethasoneProcedure: paravertebral blockDrug: BupivacaineOther: isotonic saline
- First Posted Date
- 2017-03-09
- Last Posted Date
- 2017-07-19
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 50
- Registration Number
- NCT03074773
- Locations
- 🇪🇬
Amany Hassan Saleh, Cairo, Egypt
Combination Chemotherapy Including Cisplatin, Ifosfamide, Gemcitabine, L-asparaginase, Etoposide and Dexamethasone as Treatment of Newly Diagnosed and Relapsed/Refractory Peripheral T Cell Lymphomas
- Conditions
- Peripheral T Cell Lymphoma
- Interventions
- First Posted Date
- 2017-03-07
- Last Posted Date
- 2018-06-11
- Lead Sponsor
- The University of Hong Kong
- Target Recruit Count
- 50
- Registration Number
- NCT03071822
- Locations
- 🇭🇰
The University of Hong Kong, Hong Kong, Hong Kong
Study of Chemotherapy With or Without Hepatic Arterial Infusion for Patients With Unresectable Metastatic Colorectal Cancer to the Liver
- Conditions
- Colorectal Adenocarcinoma Metastatic to the Liver
- Interventions
- First Posted Date
- 2017-03-03
- Last Posted Date
- 2019-05-21
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Registration Number
- NCT03069950
- Locations
- 🇺🇸
Memorial Sloan Kettering Commack, Commack, New York, United States
🇺🇸Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey, United States
🇺🇸Memoral Sloan Kettering Westchester, Harrison, New York, United States
Status Migrainosus - Differentiating Between Responders and Non-responders
- Conditions
- Migraine
- Interventions
- First Posted Date
- 2017-02-28
- Last Posted Date
- 2018-08-31
- Lead Sponsor
- Hartford HealthCare
- Target Recruit Count
- 50
- Registration Number
- NCT03066544
- Locations
- 🇺🇸
Hartford HealthCare Headache Center, Wethersfield, Connecticut, United States
Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE)
- Conditions
- Small Cell Lung Cancer
- Interventions
- First Posted Date
- 2017-02-23
- Last Posted Date
- 2021-02-23
- Lead Sponsor
- AbbVie
- Target Recruit Count
- 444
- Registration Number
- NCT03061812
- Locations
- 🇺🇸
Georgia Cancer Center /ID# 160206, Atlanta, Georgia, United States
🇺🇸Cedars-Sinai Medical Center /ID# 157102, Beverly Hills, California, United States
🇺🇸Mitchell Cancer Institute /ID# 158151, Mobile, Alabama, United States
Addition of Clonidine to Ropivacaine in Adductor Canal Block
- Conditions
- Postoperative Pain
- Interventions
- First Posted Date
- 2017-02-17
- Last Posted Date
- 2018-05-03
- Lead Sponsor
- University of Vermont
- Target Recruit Count
- 80
- Registration Number
- NCT03057015
- Locations
- 🇺🇸
University of Vermont Medical Center, Burlington, Vermont, United States
Dexamethasone Dose in Low Volume Bupivacaine USG Supraclavicular Block
- Conditions
- DexamethasoneSupraclavicular Brachial Plexus Block
- Interventions
- Procedure: Ultrasound guided supraclavicular brachial plexus blockDrug: Dexamethasone
- First Posted Date
- 2017-02-06
- Last Posted Date
- 2017-02-06
- Lead Sponsor
- Eslam Ayman Mohamed Shawki
- Target Recruit Count
- 40
- Registration Number
- NCT03043495
- Locations
- 🇪🇬
Faculty of medicine, Cairo University teaching hospitals (Kasr Alainy), Cairo, Egypt
Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair
- Conditions
- Hernia, InguinalPain, Postoperative
- Interventions
- Procedure: Caudal-epidural nerve blockProcedure: Ilioinguinal/iliohypogastric nerve blockDrug: AcetaminophenDrug: SevofluraneDrug: RemifentanilDrug: PropofolDrug: MorphineDrug: OndansetronDrug: DexamethasoneDrug: Ketorolac
- First Posted Date
- 2017-02-03
- Last Posted Date
- 2017-11-14
- Lead Sponsor
- Alberta Children's Hospital
- Target Recruit Count
- 88
- Registration Number
- NCT03041948
- Locations
- 🇨🇦
Alberta Children's Hospital, Calgary, Alberta, Canada
🇨🇦Royal University Hospital/University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair
- Conditions
- Pain, PostoperativeTesticle Undescended
- Interventions
- Procedure: Caudal-epidural nerve blockProcedure: Ilioinguinal/iliohypogastric nerve blockDrug: AcetaminophenDrug: SevofluraneDrug: RemifentanilDrug: PropofolDrug: MorphineDrug: OndansetronDrug: DexamethasoneDrug: KetorolacDrug: Ropivacaine
- First Posted Date
- 2017-02-03
- Last Posted Date
- 2022-02-16
- Lead Sponsor
- Alberta Children's Hospital
- Target Recruit Count
- 90
- Registration Number
- NCT03041935
- Locations
- 🇨🇦
Alberta Children's Hospital, Calgary, Alberta, Canada
Preoperative Levator Ani Muscle Injection and Pudendal Nerve Block for Pain Control After Vaginal Reconstructive Surgery
- Conditions
- SurgeryPelvic Organ ProlapsePostoperative Pain
- Interventions
- Drug: BupivacaineDrug: DexamethasoneProcedure: Bilateral Levator Ani Muscle InjectionProcedure: Bilateral Pudendal Nerve BlockDrug: Saline
- First Posted Date
- 2017-02-01
- Last Posted Date
- 2020-03-09
- Lead Sponsor
- Lauren Giugale, MD
- Target Recruit Count
- 79
- Registration Number
- NCT03040011
- Locations
- 🇺🇸
Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States
Drug Development Updates
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