Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain
Associated Therapies
-

MAST Trial: Multi-modal Analgesic Strategies in Trauma

First Posted Date
2018-03-21
Last Posted Date
2021-06-18
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
1561
Registration Number
NCT03472469
Locations
🇺🇸

The University of Texas Health Science Center at Houston, Houston, Texas, United States

A Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache

Phase 4
Withdrawn
Conditions
Interventions
First Posted Date
2018-03-21
Last Posted Date
2024-11-29
Lead Sponsor
Spectrum Health - Lakeland
Registration Number
NCT03472872
Locations
🇺🇸

Lakeland Regional Healthcare, Saint Joseph, Michigan, United States

Effect of Ketorolac on Post Adenotonsillectomy Pain

First Posted Date
2018-03-16
Last Posted Date
2024-03-20
Lead Sponsor
Emory University
Target Recruit Count
63
Registration Number
NCT03467750
Locations
🇺🇸

Childrens Healthcare of Atlanta, Egleston, Atlanta, Georgia, United States

Dosing of Ketorolac in the Emergency Department

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2018-03-14
Last Posted Date
2024-11-05
Lead Sponsor
University of Missouri-Columbia
Target Recruit Count
289
Registration Number
NCT03464461
Locations
🇺🇸

University of Missouri Health Care, Columbia, Missouri, United States

Ketorolac Use in Pediatric Patients Undergoing Tonsillectomy

First Posted Date
2018-03-05
Last Posted Date
2024-10-11
Lead Sponsor
Albany Medical College
Target Recruit Count
214
Registration Number
NCT03453541
Locations
🇺🇸

Albany Medical Center, Albany, New York, United States

Anesthetics and Analgesics in Children

First Posted Date
2018-02-09
Last Posted Date
2024-01-18
Lead Sponsor
Kanecia Obie Zimmerman
Target Recruit Count
460
Registration Number
NCT03427736
Locations
🇺🇸

Baylor College of Medicine, Houston, Texas, United States

🇺🇸

Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, Illinois, United States

🇺🇸

Washington University School of Medicine, Saint Louis, Missouri, United States

and more 10 locations

Relieving Acute Pain (RAP) Study: A Pilot Study

First Posted Date
2018-02-08
Last Posted Date
2021-04-27
Lead Sponsor
University of Maryland, Baltimore
Target Recruit Count
3
Registration Number
NCT03426137
Locations
🇺🇸

University of Maryland, Baltimore, Maryland, United States

Efficacy of Block Injection of an Anti Inflammatory Medicine in Patients With Mandibular Dental Pain

First Posted Date
2018-01-25
Last Posted Date
2019-01-15
Lead Sponsor
Azad University of Medical Sciences
Target Recruit Count
60
Registration Number
NCT03410212
Locations
🇮🇷

Dental Branch, AZad UMS, Tehran, Iran, Islamic Republic of

Wound Infiltration With Ketorolac Versus Lidocaine for Postoperative Analgesia After Total Abdominal Hysterectomy

First Posted Date
2018-01-09
Last Posted Date
2018-01-09
Lead Sponsor
Ain Shams University
Target Recruit Count
80
Registration Number
NCT03394001
Locations
🇪🇬

Ain Shams University hospitals, Cairo, Egypt

Pain Management in Outpatient Urologic Procedures

Early Phase 1
Completed
Conditions
Interventions
First Posted Date
2018-01-08
Last Posted Date
2020-06-11
Lead Sponsor
University Hospitals Cleveland Medical Center
Target Recruit Count
150
Registration Number
NCT03393364
Locations
🇺🇸

University Hospitals, Cleveland, Ohio, United States

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