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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery

Phase 3
Completed
Conditions
ACL Injury
Postoperative Pain
Interventions
Drug: Oxycodone-Acetaminophen
First Posted Date
2020-01-29
Last Posted Date
2021-12-21
Lead Sponsor
University Hospitals Cleveland Medical Center
Target Recruit Count
49
Registration Number
NCT04246554
Locations
🇺🇸

UH Cleveland Medical Center, Cleveland, Ohio, United States

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery

Phase 3
Completed
Conditions
Opioid Use
Postoperative Complications
Pain, Postoperative
Ketorolac Adverse Reaction
Meniscus Tear, Tibial
Interventions
Drug: Oxycodone-Acetaminophen
First Posted Date
2020-01-29
Last Posted Date
2022-03-03
Lead Sponsor
University Hospitals Cleveland Medical Center
Target Recruit Count
48
Registration Number
NCT04246541
Locations
🇺🇸

UH Cleveland Medical Center, Cleveland, Ohio, United States

Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Post-craniotomy Pain

Phase 4
Conditions
Pain
Supratentorial Brain Tumor
Interventions
First Posted Date
2019-10-28
Last Posted Date
2020-01-22
Lead Sponsor
Beijing Tiantan Hospital
Target Recruit Count
100
Registration Number
NCT04141319

Ibuprofen Versus Ketorolac by Mouth in the Treatment of Acute Pain From Osteoarticular Trauma

Phase 3
Completed
Conditions
Acute Pain Due to Trauma
Interventions
First Posted Date
2019-10-21
Last Posted Date
2022-01-06
Lead Sponsor
IRCCS Burlo Garofolo
Target Recruit Count
212
Registration Number
NCT04133623
Locations
🇮🇹

Azienda Ospedaliera Santa Maria degli Angeli, Pordenone, Italy

🇮🇹

Institute for Maternal and Child Health - IRCCS Burlo Garofolo-, Trieste, Italy

🇮🇹

Ospedale Santa Maria della Misericordia, Udine, Italy

Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial

Phase 4
Terminated
Conditions
Full Thickness Rotator Cuff Tear
Rotator Cuff Tendinitis
Interventions
First Posted Date
2019-10-04
Last Posted Date
2023-12-14
Lead Sponsor
Michael Khazzam
Target Recruit Count
82
Registration Number
NCT04115644
Locations
🇺🇸

University of Texas Southwestern Medical Center, Dallas, Texas, United States

🇺🇸

John Hopkins Shoulder & Sports Medicine, Baltimore, Maryland, United States

Prospective Randomized Controlled Trial for Pain Relief After Office Ureteral Stent Removal

Phase 2
Completed
Conditions
Pain
Urinary Stone
Urinary Calculi
Interventions
Drug: normal saline
First Posted Date
2019-10-02
Last Posted Date
2024-01-10
Lead Sponsor
University of Texas Southwestern Medical Center
Target Recruit Count
125
Registration Number
NCT04112160
Locations
🇺🇸

UT Southwestern Medical Center, Dallas, Texas, United States

Continuous Vs Intermittent Ketorolac for Pain Control in Peds CV Surgery

Phase 4
Recruiting
Conditions
Congenital Heart Disease in Children
Interventions
First Posted Date
2019-07-31
Last Posted Date
2025-02-19
Lead Sponsor
Phoenix Children's Hospital
Target Recruit Count
166
Registration Number
NCT04040452
Locations
🇺🇸

Phoenix Children's Hospital, Phoenix, Arizona, United States

Battlefield Acupuncture for Acute/Subacute Back Pain in the Emergency Department

Not Applicable
Completed
Conditions
Low Back Pain, Mechanical
Interventions
First Posted Date
2019-06-25
Last Posted Date
2019-06-26
Lead Sponsor
San Antonio Military Medical Center
Target Recruit Count
26
Registration Number
NCT03996564

ICE-T Pain Regimen for Total Laparoscopic Hysterectomy

Phase 4
Completed
Conditions
Opioid Substitution Treatment
Interventions
First Posted Date
2019-06-14
Last Posted Date
2025-01-24
Lead Sponsor
MetroHealth Medical Center
Target Recruit Count
66
Registration Number
NCT03987022
Locations
🇺🇸

MetroHealth Medical Center, Cleveland, Ohio, United States

Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial

Phase 2
Recruiting
Conditions
Preeclampsia Severe
Preeclampsia Postpartum
Interventions
First Posted Date
2019-06-07
Last Posted Date
2024-04-09
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
286
Registration Number
NCT03978767
Locations
🇺🇸

Barnes Jewish Hospital, Saint Louis, Missouri, United States

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