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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

PROUD Study - Preventing Opioid Use Disorders

Phase 4
Terminated
Conditions
Opioid Use
Anesthesia
Interventions
First Posted Date
2021-02-23
Last Posted Date
2023-06-22
Lead Sponsor
Emory University
Target Recruit Count
57
Registration Number
NCT04766996
Locations
🇺🇸

Emory University Orthopaedic and Spine Hospital, Atlanta, Georgia, United States

Intramuscular Ketorolac at Two Single-Dose Regimens

Phase 4
Completed
Conditions
Musculoskeletal Pain
Analgesia
Adverse Event
Interventions
First Posted Date
2021-02-21
Last Posted Date
2021-02-21
Lead Sponsor
William Beaumont Army Medical Center
Target Recruit Count
110
Registration Number
NCT04763876
Locations
🇺🇸

William Beaumont Army Medical Center, El Paso, Texas, United States

Evaluation of Post-operative Pain and Expression of IL-8 Using Ketolac or Cryoirrigation as a Final Flush in Single Visit Endodontic Treatment in Teeth With Symptomatic Irreversible Pulpitis and Apical Periodontitis.Randomized Clinical Trial.

Phase 1
Conditions
Post-operative Pain
Interventions
Other: Cryotherapy
Other: Saline
First Posted Date
2021-02-02
Last Posted Date
2021-02-02
Lead Sponsor
Cairo University
Target Recruit Count
39
Registration Number
NCT04733326
Locations
🇪🇬

Faculty of dentistry, Cairo univresity, Giza, Egypt

Efficacy and Safety of Escócia Association in the Treatment of Acute Pain

Phase 2
Withdrawn
Conditions
Acute Pain
Interventions
Drug: Escócia association
Other: Placebo Scopolamine
Other: Placebo Ketorolac
Other: Placebo Escócia association
First Posted Date
2020-12-14
Last Posted Date
2023-09-08
Lead Sponsor
EMS
Registration Number
NCT04666701

An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision

Phase 2
Completed
Conditions
Pain, Postoperative
Phimosis
Balanitis
Paraphimosis
Interventions
First Posted Date
2020-11-30
Last Posted Date
2024-08-02
Lead Sponsor
Alberta Children's Hospital
Target Recruit Count
100
Registration Number
NCT04646967
Locations
🇨🇦

Alberta Children's Hospital, Calgary, Alberta, Canada

A Pilot Study on the Use of Methoxyflurane (Penthrox®) for Pain Control in the Emergency Department

Phase 3
Completed
Conditions
Acute Traumatic Pain
Interventions
First Posted Date
2020-11-06
Last Posted Date
2020-12-08
Lead Sponsor
Hospital Authority, Hong Kong
Target Recruit Count
40
Registration Number
NCT04618497
Locations
🇭🇰

Hospital Authority, Hong Kong, Hong Kong

The Analgesic Efficacy of Magnesium and Ketorolac in Ultrasound Supraclavicular Block

Phase 4
Completed
Conditions
Postoperative Pain
Interventions
First Posted Date
2020-09-18
Last Posted Date
2022-10-05
Lead Sponsor
Fayoum University Hospital
Target Recruit Count
80
Registration Number
NCT04554862
Locations
🇪🇬

Fayoum University hospital, Madīnat Al Fayyūm, Faiyum Governorate, Egypt

Ketorolac for Moderate to Severe Abdominal Pain in Children

Phase 3
Completed
Conditions
Child, Only
Abdominal Pain
Appendicitis
Emergencies
Analgesia
Interventions
First Posted Date
2020-08-27
Last Posted Date
2023-02-28
Lead Sponsor
Hamilton Health Sciences Corporation
Target Recruit Count
105
Registration Number
NCT04528563
Locations
🇨🇦

McMaster Children's Hospital, Hamilton, Ontario, Canada

Opioid-Free Anesthetic for Tonsillectomy

Phase 4
Terminated
Conditions
Tonsillitis
Opioid Use
Sleep Disorder
Surgery
Anesthesia
Interventions
First Posted Date
2020-08-27
Last Posted Date
2024-12-20
Lead Sponsor
Children's Hospital of Philadelphia
Target Recruit Count
35
Registration Number
NCT04528173
Locations
🇺🇸

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

🇺🇸

University of Tennessee Health Science Center; St. Jude Children's Research Hospital, Memphis, Tennessee, United States

INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study

Phase 1
Active, not recruiting
Conditions
Diabetic Retinopathy
Interventions
Drug: Placebo - Preservative-free artificial tears
Other: Aqueous PGE2 and inflammatory cytokines measurements
First Posted Date
2020-08-10
Last Posted Date
2024-03-06
Lead Sponsor
Stephen J. Kim, MD
Target Recruit Count
264
Registration Number
NCT04505566
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

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