MedPath

Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain
Associated Therapies
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A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain.

Phase 4
Completed
Conditions
Back Pain Without Radiation
Low Back Pain
Interventions
Drug: Ketorolac
Drug: Ibuprofen
Drug: Diclofenac
Behavioral: Educational Intervention
First Posted Date
2019-03-04
Last Posted Date
2022-05-31
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
198
Registration Number
NCT03861611
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Teh Effect of Subgingival Irrigation Wif Ketorolac and Chlorhexidine in Patients Wif Chronic Periodontist

Phase 2
Completed
Conditions
Chronic Periodontitis
Interventions
First Posted Date
2019-02-11
Last Posted Date
2019-07-05
Lead Sponsor
Amirhossein Farahmand
Target Recruit Count
2
Registration Number
NCT03836781
Locations
🇮🇷

Amirhossein Farahmand, Tehran, Iran, Islamic Republic of

Nonopioid Analgesia After Labral Surgery

Phase 2
Recruiting
Conditions
Narcotic Use
Interventions
First Posted Date
2019-01-31
Last Posted Date
2019-01-31
Lead Sponsor
Henry Ford Health System
Target Recruit Count
100
Registration Number
NCT03825809
Locations
🇺🇸

Henry Ford Health System, Detroit, Michigan, United States

Lumbar Erector Spinae Plane Block for Back Surgery

Phase 3
Conditions
Surgery
Nerve Block
Back Pain
Spinal Fusion
Anaesthesia
Pain, Postoperative
Anesthesia, Local
Interventions
First Posted Date
2019-01-31
Last Posted Date
2022-08-05
Lead Sponsor
Dr M. B. Breebaart
Target Recruit Count
80
Registration Number
NCT03825198
Locations
🇧🇪

University Hospital Antwerp, Antwerp, Belgium

🇧🇪

AZ KLina, Brasschaat, Antwerp, Belgium

Post-Op Pain Control for Prophylactic Intramedullary Nailing.

Phase 3
Recruiting
Conditions
Bone Metastases
Lymphoma
Multiple Myeloma
Opioid Use
Pain
Interventions
First Posted Date
2019-01-30
Last Posted Date
2024-11-06
Lead Sponsor
St. Louis University
Target Recruit Count
60
Registration Number
NCT03823534
Locations
🇺🇸

Saint Louis University, Saint Louis, Missouri, United States

Nonopioid Analgesia After Arthroscopic Meniscus Surgery

Early Phase 1
Completed
Conditions
Meniscus Disorder
Narcotic Use
Interventions
First Posted Date
2019-01-29
Last Posted Date
2023-12-05
Lead Sponsor
Henry Ford Health System
Target Recruit Count
61
Registration Number
NCT03820193
Locations
🇺🇸

Henry Ford Health System, Detroit, Michigan, United States

Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction

Phase 2
Completed
Conditions
Anterior Cruciate Ligament Injury
Interventions
First Posted Date
2019-01-28
Last Posted Date
2021-02-11
Lead Sponsor
Henry Ford Health System
Target Recruit Count
62
Registration Number
NCT03818932
Locations
🇺🇸

Henry Ford Health System, Detroit, Michigan, United States

Nonopioid Analgesia After Rotator Cuff Repair

Phase 2
Completed
Conditions
Rotator Cuff Tear
Interventions
First Posted Date
2019-01-28
Last Posted Date
2024-04-02
Lead Sponsor
Henry Ford Health System
Target Recruit Count
70
Registration Number
NCT03818919
Locations
🇺🇸

Health Ford Health System, Detroit, Michigan, United States

Effect of Toradol on Post-operative Foot and Ankle Healing

Phase 4
Completed
Conditions
Trauma Injury
Ankle Fractures
Interventions
Drug: Ketorolac
Other: No ketorolac
First Posted Date
2018-11-01
Last Posted Date
2018-11-01
Lead Sponsor
Rothman Institute Orthopaedics
Target Recruit Count
128
Registration Number
NCT03727048

Phase 2 Herniorrhaphy Study for Opioid Elimination

Phase 2
Completed
Conditions
Postoperative Pain
Interventions
Drug: HTX-011
Device: Luer lock applicator
Device: Vial access device
Drug: Ibuprofen
Drug: Acetaminophen
Drug: Ketorolac
First Posted Date
2018-10-04
Last Posted Date
2021-10-25
Lead Sponsor
Heron Therapeutics
Target Recruit Count
63
Registration Number
NCT03695367
Locations
🇺🇸

Anaheim Clinical Trials, LLC, Anaheim, California, United States

🇺🇸

Lotus Clinical Research, LLC, Pasadena, California, United States

🇺🇸

JBR Clinical Research, Salt Lake City, Utah, United States

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