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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

Comparison of Ketorolac at Three Doses in Children With Acute Pain

Phase 3
Recruiting
Conditions
Acute Pain
Biliary Colic
Abdominal Pain
Migraine
Appendicitis Acute
Renal Colic
Interventions
First Posted Date
2022-12-07
Last Posted Date
2023-09-06
Lead Sponsor
Hamilton Health Sciences Corporation
Target Recruit Count
171
Registration Number
NCT05641363
Locations
🇨🇦

McMaster Children's Hospital, Hamilton, Ontario, Canada

🇨🇦

McMaster University Medical Centre, Hamilton, Ontario, Canada

Ibuprofen Versus Ketorolac for Perioperative Pain Control After Open Hysterectomy

Not Applicable
Completed
Conditions
Postoperative Pain
Hysterectomy
Interventions
First Posted Date
2022-11-09
Last Posted Date
2023-07-27
Lead Sponsor
Cairo University
Target Recruit Count
100
Registration Number
NCT05610384
Locations
🇪🇬

Ahmed Mohamed Hasanin, Cairo, Egypt

Efficacy and Safety Study of Ketorolac / Pitofenone / Fenpiverinium for the Treatment of Patients With Pain After Surgical Abdominal and Pelvic Operations

Phase 2
Completed
Conditions
Postsurgical Pain
Interventions
First Posted Date
2022-11-07
Last Posted Date
2022-11-07
Lead Sponsor
Darnitsa Pharmaceutical Company
Target Recruit Count
424
Registration Number
NCT05607641
Locations
🇺🇦

Communal noncomercial enterprise of the Kharkiv Regional Council "Regional Medical Clinical Center of Urology and Nephrology named after V.I. Shapovala", urology department №5, Kharkiv, Ukraine

🇺🇦

Medical Center of the LLC "Harmony of Beauty", Kyiv, Ukraine

🇺🇦

State Institution "Institute of Urology of the National Academy of Medical Sciences of Ukraine", I Urological Department, Kyiv, Ukraine

and more 11 locations

Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy

Phase 2
Recruiting
Conditions
Opioid Use
Pain Management
Prostate Cancer
Interventions
First Posted Date
2022-10-28
Last Posted Date
2025-02-18
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
100
Registration Number
NCT05597878
Locations
🇺🇸

Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, United States

Ketorolac Intravenous Regional Analgesia in Lower Limb Surgeries

Not Applicable
Recruiting
Conditions
Postoperative Pain, Acute
Interventions
Other: Control
First Posted Date
2022-09-16
Last Posted Date
2024-02-06
Lead Sponsor
Mansoura University
Target Recruit Count
76
Registration Number
NCT05543785
Locations
🇪🇬

Mansoura University Hospitals, Mansoura, Egypt

Paracetamol Compared With Ketorolac for Post-operative Analgetic

Phase 4
Completed
Conditions
Pain, Postoperative
Interventions
First Posted Date
2022-08-31
Last Posted Date
2022-09-06
Lead Sponsor
Indonesia University
Target Recruit Count
85
Registration Number
NCT05523102
Locations
🇮🇩

Cipto Mangunkusumo Hospital, Jakarta Pusat, DKI Jakarta, Indonesia

Bellomic PCA in Laparoscopic Gynecologic Surgery

Not Applicable
Completed
Conditions
Laparoscopic Gynecological Surgery
Interventions
First Posted Date
2022-08-05
Last Posted Date
2023-05-18
Lead Sponsor
Seoul National University Bundang Hospital
Target Recruit Count
72
Registration Number
NCT05489796
Locations
🇰🇷

Seoul National Univ. Bundang Hospital, Seongnam, Gyeonggi, Korea, Republic of

Opioid-Free Pain Protocol After Shoulder Arthroplasty

First Posted Date
2022-08-05
Last Posted Date
2025-02-17
Lead Sponsor
Henry Ford Health System
Target Recruit Count
80
Registration Number
NCT05488847
Locations
🇺🇸

Henry Ford Health, Detroit, Michigan, United States

Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery

First Posted Date
2022-06-10
Last Posted Date
2022-06-10
Lead Sponsor
University of Puerto Rico
Target Recruit Count
100
Registration Number
NCT05413902
Locations
🇵🇷

Puerto Rico Medical Center - University District Hospital, San Juan, Puerto Rico

Effect of Paracetamol and Ketorolac on RANK-L Levels in Patients Starting Orthodontic Treatment

Phase 4
Conditions
Malocclusion
Pain, Acute
Interventions
First Posted Date
2022-05-20
Last Posted Date
2022-05-20
Lead Sponsor
University of Guadalajara
Target Recruit Count
24
Registration Number
NCT05383820
Locations
🇲🇽

Juan Ramón Gómez Sandoval, Guadalajara, Jaisco, Mexico

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