Ketorolac

Generic Name: Ketorolac

Brand Names: Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik

Drug Type: Small Molecule

Chemical Formula: C_₁₅H_₁₃NO_₃

CAS Number: 74103-06-3

Unique Ingredient Identifier: YZI5105V0L

Background: Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.
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Indication: Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid...

Associated Conditions: Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

Associated Therapies: -

Clinical Trials

Ketorolac in Palatoplasty

Phase 4

Recruiting

Conditions: Cleft Lip and Palate

Interventions: Drug: Placebo
Drug: Ketorolac

First Posted Date: 2021-02-25

Last Posted Date: 2023-12-11

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 74

Registration Number: NCT04771156

Locations: 🇺🇸
The University of Texas Health Science Center at Houston, Houston, Texas, United States

Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study

Completed

Conditions: Hammertoe
Bunion of Unspecified Foot
Ankle Fractures
Achilles Tendon Surgery
Bunionette of Unspecified Foot

Interventions: Drug: Acetominophen
Drug: Toradol
Drug: Meloxicam
Drug: Cyclobenzaprine
Drug: Lyrica

First Posted Date: 2021-02-25

Last Posted Date: 2023-04-27

Lead Sponsor: Prisma Health-Midlands

Target Recruit Count: 72

Registration Number: NCT04771741

Locations: 🇺🇸
Prisma Health Midlands, Columbia, South Carolina, United States

PROUD Study - Preventing Opioid Use Disorders

First Posted Date: 2021-02-23

Last Posted Date: 2023-06-22

Lead Sponsor: Emory University

Target Recruit Count: 57

Registration Number: NCT04766996

Locations: 🇺🇸
Emory University Orthopaedic and Spine Hospital, Atlanta, Georgia, United States

Evaluation of Post-operative Pain and Expression of IL-8 Using Ketolac or Cryoirrigation as a Final Flush in Single Visit Endodontic Treatment in Teeth With Symptomatic Irreversible Pulpitis and Apical Periodontitis.Randomized Clinical Trial.

Phase 1

Conditions: Post-operative Pain

Interventions: Other: Cryotherapy
Drug: Ketorolac Tromethamine
Other: Saline

First Posted Date: 2021-02-02

Last Posted Date: 2021-02-02

Lead Sponsor: Cairo University

Target Recruit Count: 39

Registration Number: NCT04733326

Locations: 🇪🇬
Faculty of dentistry, Cairo univresity, Giza, Egypt

Efficacy and Safety of Escócia Association in the Treatment of Acute Pain

Phase 2

Withdrawn

Conditions: Acute Pain

Interventions: Drug: Escócia association
Other: Placebo Scopolamine
Other: Placebo Ketorolac
Drug: Ketorolac Tromethamine
Drug: Scopolamine
Other: Placebo Escócia association

First Posted Date: 2020-12-14

Last Posted Date: 2023-09-08

Lead Sponsor: EMS

Registration Number: NCT04666701

An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision

Phase 2

Completed

Conditions: Pain, Postoperative
Phimosis
Balanitis
Paraphimosis

Interventions: Drug: Bupivacain
Drug: Sevoflurane
Drug: Acetaminophen
Drug: Ibuprofen
Drug: Ketorolac

First Posted Date: 2020-11-30

Last Posted Date: 2024-08-02

Lead Sponsor: Alberta Children's Hospital

Target Recruit Count: 100

Registration Number: NCT04646967

Locations: 🇨🇦
Alberta Children's Hospital, Calgary, Alberta, Canada

A Pilot Study on the Use of Methoxyflurane (Penthrox®) for Pain Control in the Emergency Department

Phase 3

Completed

Conditions: Acute Traumatic Pain

Interventions: Drug: Ketorolac
Drug: Methoxyflurane

First Posted Date: 2020-11-06

Last Posted Date: 2020-12-08

Lead Sponsor: Hospital Authority, Hong Kong

Target Recruit Count: 40

Registration Number: NCT04618497

Locations: 🇭🇰
Hospital Authority, Hong Kong, Hong Kong

The Analgesic Efficacy of Magnesium and Ketorolac in Ultrasound Supraclavicular Block

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: Magnesium sulfate
Drug: Ketorolac Tromethamine
Procedure: supraclavicular block

First Posted Date: 2020-09-18

Last Posted Date: 2022-10-05

Lead Sponsor: Fayoum University Hospital

Target Recruit Count: 80

Registration Number: NCT04554862

Locations: 🇪🇬
Fayoum University hospital, Madīnat Al Fayyūm, Faiyum Governorate, Egypt

Opioid-Free Anesthetic for Tonsillectomy

Phase 4

Terminated

Conditions: Tonsillitis
Opioid Use
Sleep Disorder
Surgery
Anesthesia

Interventions: Drug: Ketorolac
Drug: Morphine
Drug: Fentanyl
Drug: Dexmedetomidine

First Posted Date: 2020-08-27

Last Posted Date: 2024-12-20

Lead Sponsor: Children's Hospital of Philadelphia

Target Recruit Count: 35

Registration Number: NCT04528173

Locations: 🇺🇸
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
🇺🇸
University of Tennessee Health Science Center; St. Jude Children's Research Hospital, Memphis, Tennessee, United States

Toradol (Ketorolac) in Breast Surgery to Reduce Pain & Opioid Use

Phase 1

Completed

Conditions: Breast Reduction
Breast Reconstruction

Interventions: Drug: Ketorolac Tromethamine
Other: Saline

First Posted Date: 2020-06-19

Last Posted Date: 2023-02-10

Lead Sponsor: Carilion Clinic

Target Recruit Count: 183

Registration Number: NCT04439396

Locations: 🇺🇸
James T. Thompson, Roanoke, Virginia, United States

Drug Development Updates

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