Sevoflurane

Generic Name: Sevoflurane

Brand Names: Sevorane, Sojourn, Ultane

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃F_₇O

CAS Number: 28523-86-6

Unique Ingredient Identifier: 38LVP0K73A

Background: Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.

Indication: Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Associated Conditions: -

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia

Clinical Trials

Airway Complications After LMA in Children

Not Applicable

Completed

Conditions: Anesthesia Recovery

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2018-06-12

Last Posted Date: 2021-08-24

Lead Sponsor: American University of Beirut Medical Center

Target Recruit Count: 135

Registration Number: NCT03553082

Locations: 🇱🇧
American University of Beirut, Beirut, Lebanon

Opioid-Free Shoulder Arthroplasty

Phase 4

Completed

Conditions: Arthritis;Inflammatory
Opioid Use
Shoulder Osteoarthritis
Avascular Necrosis
Rotator Cuff Tear

Interventions: Drug: Gabapentin
Drug: Celecoxib
Drug: toradol
Drug: acetaminophen
Drug: regional block
Drug: propofol
Drug: IV lidocaine
Drug: rocuronium
Drug: vecuronium
Drug: sevoflurane
Drug: desflurane

First Posted Date: 2018-05-30

Last Posted Date: 2020-10-14

Lead Sponsor: OrthoCarolina Research Institute, Inc.

Target Recruit Count: 86

Registration Number: NCT03540030

Locations: 🇺🇸
OrthoCarolina Research Institute, Charlotte, North Carolina, United States

The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Robotic-assisted Laparoscopic Radical Prostatectomy Under Sevoflurane, Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

Not Applicable

Completed

Conditions: Robotic-assisted Laparoscopic Radical Prostatectomy

Interventions: Drug: propofol and remifentanil
Drug: sevoflurane
Drug: desflurane

First Posted Date: 2018-05-29

Last Posted Date: 2019-02-11

Lead Sponsor: Yonsei University

Target Recruit Count: 69

Registration Number: NCT03539003

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea, Korea, Republic of

QLB After Nephrectomy

Not Applicable

Completed

Conditions: Chronic Postoperative Pain
Pain, Postoperative

Interventions: Procedure: QLB
Device: PCA
Procedure: GA
Drug: Oxycodone
Drug: Sevoflurane
Drug: Fentanyl
Drug: Rocuronium

First Posted Date: 2018-05-18

Last Posted Date: 2023-11-24

Lead Sponsor: Medical University of Lublin

Target Recruit Count: 105

Registration Number: NCT03529201

Locations: 🇵🇱
Department of Anesthesiology and Intensive Care, F. Chopin Hospital in Rzeszów, Rzeszów, Poland
🇵🇱
Department of Anesthesiology and Intensive Care, J. Śniadecki Hospital in Białystok, Białystok, Poland