Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Investigation of Cerebral Motor Activity Modulations Following Median Nerve Stimulation During General Anaesthesia

Early Phase 1

Recruiting

Conditions: Accidental Awareness During General Anesthesia

Interventions: Drug: Propofol
Device: Median nerve stimulation
Device: EEG measurements

First Posted Date: 2022-03-09

Last Posted Date: 2023-02-16

Lead Sponsor: Brugmann University Hospital

Target Recruit Count: 30

Registration Number: NCT05272202

Locations: 🇧🇪
CHU Brugmann, Brussels, Belgium

Ketamine and Kidney Injury in Cardiac Surgery

Phase 4

Recruiting

Conditions: Cardiac Surgery

Interventions: Drug: Ketamine
Drug: Propofol

First Posted Date: 2022-03-07

Last Posted Date: 2024-01-12

Lead Sponsor: Mayo Clinic

Target Recruit Count: 200

Registration Number: NCT05268562

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Effects of Ciprofol Anesthesia on Learning and Memory Function and Antidepressant Effects of ECT in Depressive Patients

Early Phase 1

Not yet recruiting

Conditions: Depressive Disorder

Interventions: Drug: Propofol
Drug: ciprofol

First Posted Date: 2022-03-04

Last Posted Date: 2022-03-04

Lead Sponsor: First Affiliated Hospital of Chongqing Medical University

Target Recruit Count: 390

Registration Number: NCT05266560

Inhalational (Sevoflurane) Versus Intravenous (Propofol) Sedation in Adults With a Moderate Form of ARDS

Phase 3

Suspended

Conditions: Acute Respiratory Distress Syndrome

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2022-02-28

Last Posted Date: 2023-02-01

Lead Sponsor: Negovsky Reanimatology Research Institute

Target Recruit Count: 310

Registration Number: NCT05259631

Locations: 🇷🇺
Demikhov Municipal Clinical Hospital 68, Moscow, Russian Federation

Effect on Early Cognition Under Sedation by Rimazole Toluenesulfonate in Old Patient Undergoing Colonoscopy

Phase 4

Recruiting

Conditions: Cognition

Interventions: Drug: Remimazolam tosilate
Drug: Propofol
Other: saline solution

First Posted Date: 2022-02-24

Last Posted Date: 2024-03-18

Lead Sponsor: RenJi Hospital

Target Recruit Count: 90

Registration Number: NCT05255211

Locations: 🇨🇳
Yongming Chen, Shanghai, Shanghai, China

Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation

Not Applicable

Conditions: Patient With Nasolacrimal Duct Obstruction
External Dacryocystorhinostomy Operation

Interventions: Drug: Bupivacaine
Drug: Nitroglycerine
Drug: Propofol
Drug: Fentanyl
Drug: Atracurium Besylate
Procedure: Mechanical ventilation
Drug: Sevoflurane
Drug: Lactated Ringers
Other: Head-up tilt
Drug: Paracetamol

First Posted Date: 2022-02-15

Last Posted Date: 2022-02-15

Lead Sponsor: Mansoura University

Target Recruit Count: 64

Registration Number: NCT05241054

Locations: 🇪🇬
Mansoura University, Mansoura, DK, Egypt

Safety and Efficacy of Maintenance of Etomidate in General Anesthesia

Phase 4

Completed

Conditions: General Anesthesia

Interventions: Drug: Propofol
Drug: Etomidate

First Posted Date: 2022-02-04

Last Posted Date: 2024-06-05

Lead Sponsor: Henan Provincial People's Hospital

Target Recruit Count: 1080

Registration Number: NCT05223907

Locations: 🇨🇳
Henan Provincial People's Hospital, Zhengzhou, Henan, China

Safety of Propofol Sedation ( > 200 Mg) for Colonoscopy.

Recruiting

Conditions: Safety Issues

First Posted Date: 2022-01-28

Last Posted Date: 2024-12-03

Lead Sponsor: Showa Inan General Hospital

Target Recruit Count: 300

Registration Number: NCT05213208

Locations: 🇯🇵
Showa Inan General hospital, Komagane, Nagano, Japan

General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia

Recruiting

Conditions: General Anesthetic
Electroencephalogram

Interventions: Drug: propofol
Drug: S-ketamine
Drug: sevoflurane

First Posted Date: 2022-01-27

Last Posted Date: 2024-03-20

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 366

Registration Number: NCT05210764

Locations: 🇨🇳
Peking University First Hospital, Beijing, China

Remimazolam and Propofol Anesthesia in Elderly Patients

Not Applicable

Completed

Conditions: Hemodynamics

Interventions: Drug: Remimazolam Besylate 6 mg/kg/hr
Drug: Remimazolam Besylate 12 mg/kg/hr
Drug: Propofol

First Posted Date: 2022-01-21

Last Posted Date: 2023-07-25

Lead Sponsor: Ajou University School of Medicine

Target Recruit Count: 69

Registration Number: NCT05201300

Locations: 🇰🇷
Ajou University Hospital, Suwon, Gyeonggi-do, Korea, Republic of

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