Verapamil

Generic Name: Verapamil

Brand Names: Calan, Isoptin, Tarka, Verelan

Drug Type: Small Molecule

Chemical Formula: C_₂₇H_₃₈N_₂O_₄

CAS Number: 52-53-9

Unique Ingredient Identifier: CJ0O37KU29

Background: Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs like diltiazem and flunarizine, but is chemically unrelated to other cardioactive medications. Verapamil is administered as a racemic mixture containing equal amounts of the S- and R-enantiomer, each of which is pharmacologically distinct - the S-enantiomer carries approximately 20-fold greater potency than the R-enantiomer, but is metabolized at a higher rate.

Indication: Verapamil is indicated in the treatment of vasopastic (i.e. Prinzmetal's) angina, unstable angina, and chronic stable angina. It is also indicated to treat hypertension, for the prophylaxis of repetitive paroxysmal supraventricular tachycardia, and in combination with digoxin to control ventricular rate in patients with atrial fibrillation or atrial flutter. Given intravenously, it is indicated for the treatment of various supraventricular tachyarrhythmias, including rapid conversion to sinus rhythm in patients with supraventricular tachycardia and for temporary control of ventricular rate in patients with atrial fibrillation or atrial flutter.

Verapamil is commonly used off-label for prophylaxis of cluster headaches.

Associated Conditions: Chronic Stable Angina Pectoris, Cluster Headache, Heart Rate, Hypertension, Paroxysmal Supraventricular Tachycardia (PSVT), Supra-ventricular Tachyarrhythmias, Unstable Angina Pectoris, Vasospastic Angina

Clinical Trials

Treatment of Tinnitus With Migraine Medications

Phase 4

Recruiting

Conditions: Tinnitus
Tinnitus, Subjective

Interventions: Drug: Verapamil + paroxetine
Other: Placebo
Drug: Nortriptyline + topiramate

First Posted Date: 2020-05-27

Last Posted Date: 2023-01-09

Lead Sponsor: University of California, Irvine

Target Recruit Count: 150

Registration Number: NCT04404439

Locations: 🇺🇸
University of California, Irvine Medical Center ENT Clinic (Pavilion 2), Orange, California, United States

Comparative Study Between the Efficacy of Verapamil and Bisoprolol on Reduction of Bleeding During Endoscopic Sinus Surgery Under General Anaesthesia.

Early Phase 1

Conditions: Heart Rate
Endoscopic Sinus Surgery
Blood Loss

Interventions: Drug: Placebo oral tablet
Drug: Verapamil
Drug: Bisoprolol

First Posted Date: 2020-04-22

Last Posted Date: 2021-12-03

Lead Sponsor: Assiut University

Target Recruit Count: 135

Registration Number: NCT04356196

Locations: 🇪🇬
Faculty of medicine Assiut university, Assiut, Egypt

Amiodarone or Verapamil in COVID-19 Hospitalized Patients With Symptoms

Phase 2

Completed

Conditions: COVID-19

Interventions: Drug: Amiodarone
Drug: Verapamil

First Posted Date: 2020-04-17

Last Posted Date: 2021-09-05

Lead Sponsor: Nicolaus Copernicus University

Target Recruit Count: 804

Registration Number: NCT04351763

Locations: 🇵🇱
Nicolaus Copernicus University, Bydgoszcz, Poland

Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes

Phase 3

Completed

Conditions: Type1 Diabetes

Interventions: Drug: verapamil 120mg tablet
Device: HCL
Drug: placebo
Device: non-HCL

First Posted Date: 2020-01-18

Last Posted Date: 2024-11-27

Lead Sponsor: Jaeb Center for Health Research

Target Recruit Count: 113

Registration Number: NCT04233034

Locations: 🇺🇸
Indiana University, Indianapolis, Indiana, United States
🇺🇸
Stanford University, Palo Alto, California, United States
🇺🇸
University of Minnesota, Minneapolis, Minnesota, United States

and more 3 locations

Adenosine Versus Verapamil for Management of Supraventricular Tachycardia Post- Coronary Artery Bypass Grafting

Not Applicable

Completed

Conditions: Supraventricular Tachycardia

Interventions: Drug: verapamil
Drug: adenosine

First Posted Date: 2019-12-18

Last Posted Date: 2020-12-02

Lead Sponsor: Ain Shams University

Target Recruit Count: 268

Registration Number: NCT04203368

Locations: 🇪🇬
Ain Shams university, Cairo, Egypt

A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone

Phase 1

Completed

Conditions: Healthy Adult Subjects

Interventions: Drug: Omaveloxolone
Drug: Gemfibrozil Tablets
Drug: Itraconazole capsule
Drug: Midazolam oral solution
Drug: Verapamil Pill
Drug: Repaglinide 1 MG
Drug: MetFORMIN 500 Mg Oral Tablet
Drug: Rosuvastatin
Drug: Digoxin tablet

First Posted Date: 2019-07-05

Last Posted Date: 2024-02-02

Lead Sponsor: Reata, a wholly owned subsidiary of Biogen

Target Recruit Count: 61

Registration Number: NCT04008186

Locations: 🇺🇸
Covance Clinical Research Unit (CRU) Inc., Dallas, Texas, United States

A Study to Learn About the Drug-drug Interactions of Sisunatovir in Healthy Adult Participants

Phase 1

Completed

Conditions: Respiratory Syncytial Virus Infections

Interventions: Drug: Itraconazole
Drug: Verapamil
Drug: Rifampicin
Drug: Midazolam
Drug: RV521
Drug: Placebo for RV521

First Posted Date: 2018-12-20

Last Posted Date: 2024-04-22

Lead Sponsor: Pfizer

Target Recruit Count: 82

Registration Number: NCT03782662

Locations: 🇬🇧
Richmond Pharmacology Ltd, London, United Kingdom

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

Recruiting

Conditions: Breastfed Infants of Mothers on Select DOI
Lactating Women on Select DOI

First Posted Date: 2018-04-27

Last Posted Date: 2024-12-17

Lead Sponsor: Duke University

Target Recruit Count: 1600

Registration Number: NCT03511118

Locations: 🇺🇸
Northwestern University, Chicago, Illinois, United States
🇺🇸
Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, Illinois, United States
🇺🇸
Loma Linda University Health, Loma Linda, California, United States

and more 19 locations