Esmolol
- Generic Name
- Esmolol
- Brand Names
- Brevibloc
- Drug Type
- Small Molecule
- Chemical Formula
- C16H25NO4
- CAS Number
- 81147-92-4
- Unique Ingredient Identifier
- MDY902UXSR
- Background
Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. It works by blocking beta-adrenergic receptors in the heart, which leads to decrea...
- Indication
For the rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter in perioperative, postoperative, or other emergent circumstances where short term control of ventricular rate with a short-acting agent is desirable. Also used in noncompensatory sinus tachycardia where the rapid heart rate requires specific intervention.
- Associated Conditions
- Hypertension, Tachycardia, Abnormal ventricular rate, Heart rate abnormal
- Associated Therapies
- -
A Comparison of Esmolol and Remifentanil to Reduce Blood Loss
- First Posted Date
- 2012-12-19
- Last Posted Date
- 2012-12-19
- Lead Sponsor
- Diskapi Teaching and Research Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT01752959
- Locations
- 🇹🇷
Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
Long-term PK and Safety/Tolerability Testing LDLL600 Against Esmolol in Healthy Volunteers
- First Posted Date
- 2012-12-05
- Last Posted Date
- 2015-04-21
- Lead Sponsor
- AOP Orphan Pharmaceuticals AG
- Target Recruit Count
- 14
- Registration Number
- NCT01741519
- Locations
- 🇨🇿
Cepha s.r.o, Pilsen, Czech Republic
A Comparison of the Perioperative Hemodynamic Effects of Remifentanil and Esmolol in Intracranial Surgery
- Conditions
- Interventions
- First Posted Date
- 2012-06-27
- Last Posted Date
- 2015-02-18
- Lead Sponsor
- Diskapi Teaching and Research Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT01628562
- Locations
- 🇹🇷
Diskapi Yildirim Beyazit Teaching and Research Hospital, Ankara, Turkey
Tight Hemodynamic Control in Patients Who Are Chronically on Metoprolol
- Conditions
- Interventions
- First Posted Date
- 2011-07-28
- Last Posted Date
- 2015-04-21
- Lead Sponsor
- University Health Network, Toronto
- Target Recruit Count
- 20
- Registration Number
- NCT01404767
- Locations
- 🇨🇦
University Heatlh Network, Toronto General Hopsital, Toronto, Ontario, Canada
Genetic Determinants of Hemodynamic Response to Esmolol
- First Posted Date
- 2011-07-06
- Last Posted Date
- 2011-07-06
- Lead Sponsor
- Hadassah Medical Organization
- Target Recruit Count
- 100
- Registration Number
- NCT01388036
- Locations
- 🇮🇱
Hadassah Hebrew University Medical Center, Jerusalem, Israel
Controlling Hyperadrenergic Activity in Neurologic Injury
- Conditions
- Interventions
- First Posted Date
- 2011-04-28
- Last Posted Date
- 2017-04-20
- Lead Sponsor
- Johns Hopkins University
- Registration Number
- NCT01343329
- Locations
- 🇺🇸
Johns Hopkins Hospital, Baltimore, Maryland, United States
Non-opioid Analgesia for Fast-track Surgery
- First Posted Date
- 2011-01-13
- Last Posted Date
- 2013-03-27
- Lead Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- Target Recruit Count
- 40
- Registration Number
- NCT01275911
- Locations
- 🇨🇦
Montreal General Hospital, McGill University Health Centre, Montreal, Quebec, Canada
Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage
- First Posted Date
- 2010-11-02
- Last Posted Date
- 2015-01-08
- Lead Sponsor
- University of Michigan
- Registration Number
- NCT01232400
- Locations
- 🇺🇸
University of Michigan Health System, Ann Arbor, Michigan, United States
Heart Rate Control With Esmolol in Septic Shock
- First Posted Date
- 2010-11-01
- Last Posted Date
- 2013-01-24
- Lead Sponsor
- Andrea Morelli
- Target Recruit Count
- 154
- Registration Number
- NCT01231698
- Locations
- 🇮🇹
Department of Anesthesiology and Intensive care of the University of Rome La Sapienza, Rome, Italy
Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery
- First Posted Date
- 2010-10-01
- Last Posted Date
- 2019-03-01
- Lead Sponsor
- Loma Linda University
- Target Recruit Count
- 70
- Registration Number
- NCT01212874
- Locations
- 🇺🇸
Loma Linda University, Loma Linda, California, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.