Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Not Applicable

Completed

Conditions: Postoperative Nausea and Vomiting

Interventions: Procedure: Automated recommendation at the start of the case
Procedure: Automated notification at the start of surgery
Procedure: Automated notification at the end of surgery
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Procedure: Elective surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Isoflurane
Drug: Desflurane
Drug: Scopolamine
Drug: Droperidol
Drug: Haloperidol
Drug: Dexamethasone
Drug: Promethazine
Drug: Meclizine
Drug: Aprepitant
Drug: Metoclopramide
Drug: Fentanyl
Drug: Sufentanil
Drug: Alfentanil
Drug: Remifentanil
Drug: Morphine
Drug: Meperidine
Drug: Hydromorphone
Drug: Methadone
Drug: Oxycodone
Drug: Oxymorphone
Drug: Hydrocodone
Drug: Ketamine
Drug: Ondansetron
Drug: Granisetron
Drug: Dolasetron mesylate
Drug: Palonosetron
Drug: Tropisetron
Drug: Ramosetron

First Posted Date: 2015-12-09

Last Posted Date: 2019-03-07

Lead Sponsor: Vanderbilt University

Target Recruit Count: 27034

Registration Number: NCT02625181

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia

Phase 2

Completed

Conditions: Coagulation Defect; Bleeding

Interventions: Drug: hydroxyethyl starch (6% 130/0.4)
Drug: Hyperbaric bupivacaine
Drug: Morphine
Drug: Isotonic 0.9 sodium chloride (NaCl) solution
Drug: Ephedrine
Drug: Atropine

First Posted Date: 2015-12-04

Last Posted Date: 2016-11-08

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT02622126

Locations: 🇪🇬
Faculty of Medicine, Assiut, Egypt

Study to Examine Pain Relief With Supplemental Intrathecal Morphine in TKA Patients

Phase 4

Conditions: Acute Pain

Interventions: Drug: Placebo
Drug: Morphine

First Posted Date: 2015-12-03

Last Posted Date: 2015-12-03

Lead Sponsor: Stony Brook University

Target Recruit Count: 54

Registration Number: NCT02620631

Locations: 🇺🇸
Stony Brook University Hospital, Stony Brook, New York, United States

Ibuprofen Compared to Morphine as a Pediatric Postoperative Pain Management Tool Following Inguinal Surgery

Not Applicable

Recruiting

Conditions: Inguinal Surgery

Interventions: Drug: Ibuprofen
Drug: Morphine

First Posted Date: 2015-11-13

Last Posted Date: 2023-03-15

Lead Sponsor: McMaster University

Target Recruit Count: 100

Registration Number: NCT02603848

Locations: 🇨🇦
McMaster Children's Hospital, Hamilton, Ontario, Canada

Reduction of Bladder Injection Pain With Belladonna Opiate Suppository

Phase 4

Completed

Conditions: Overactive Bladder
Urinary Urge Incontinence
Urinary Bladder, Neurogenic
Painful Bladder Syndrome

Interventions: Drug: Onabotulinumtoxin A (BoNT)
Drug: belladonna
Drug: Placebo
Drug: Morphine
Drug: Active B&O suppository of belladonna

First Posted Date: 2015-11-09

Last Posted Date: 2018-09-20

Lead Sponsor: Edgar LeClaire, MD

Target Recruit Count: 26

Registration Number: NCT02600715

Locations: 🇺🇸
Wichita Women's Pelvic Surgery Center at Associates in Women's Health, Wichita, Kansas, United States
🇺🇸
University of Kansas School of Medicine - Wichita, Wichita, Kansas, United States