Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Dexmedetomidine Versus Fentanyl Added to Levobupivacaine for Transversus Abdominis Plane (TAP) Block
- Conditions
- Interventions
- First Posted Date
- 2018-12-19
- Last Posted Date
- 2021-10-18
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 90
- Registration Number
- NCT03778671
- Locations
- 🇪🇬
Assiut governorate, Assiut, Egypt
Comparison of Skin Sympathetic Nerve Activity According to Different Anesthetics
- Conditions
- Interventions
- First Posted Date
- 2018-12-04
- Last Posted Date
- 2022-05-11
- Lead Sponsor
- Seoul National University Hospital
- Registration Number
- NCT03763305
Efficacy of Oxycodone-propofol Combination Compared With a Fentanyl-propofol Combination on Conscious Sedation Effect and Early Cognitive Function During Therapeutic Endoscopic Retrograde Cholangio-pancreatography
- Conditions
- Interventions
- First Posted Date
- 2018-11-28
- Last Posted Date
- 2018-11-28
- Lead Sponsor
- Changhai Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT03755609
- Locations
- 🇨🇳
Changhai Hospital, Shanghai, Shanghai, China
Sedation of Morbidly Obese for Balloon Insertion
- First Posted Date
- 2018-11-20
- Last Posted Date
- 2018-11-20
- Lead Sponsor
- Mansoura University
- Target Recruit Count
- 70
- Registration Number
- NCT03747094
- Locations
- 🇪🇬
Mansoura university, Al Manşūrah, Dkahleya, Egypt
Premedication for Less Invasive Surfactant Administration
- Conditions
- Interventions
- First Posted Date
- 2018-11-08
- Last Posted Date
- 2023-06-05
- Lead Sponsor
- University of Oulu
- Target Recruit Count
- 40
- Registration Number
- NCT03735563
- Locations
- 🇫🇮
Oulu University Hospital, Oulu, Finland
Rectal Acetaminophen Use During Oocyte Retrievals to Reduce Post-Operative Opioid Utilization
- First Posted Date
- 2018-11-06
- Last Posted Date
- 2021-06-18
- Lead Sponsor
- University of South Florida
- Target Recruit Count
- 4
- Registration Number
- NCT03732469
- Locations
- 🇺🇸
University of South Florida, Tampa, Florida, United States
Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)
- Conditions
- Interventions
- First Posted Date
- 2018-10-31
- Last Posted Date
- 2024-02-02
- Lead Sponsor
- Duke University
- Target Recruit Count
- 907
- Registration Number
- NCT03726268
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Study on the Effects of Different Premedication for LISA on Stress and Cerebral Tissue Oxygenation in Preterm Infants
- Conditions
- Interventions
- First Posted Date
- 2018-10-24
- Last Posted Date
- 2021-08-04
- Lead Sponsor
- ASST Fatebenefratelli Sacco
- Registration Number
- NCT03718507
Comparative Clinical Study of Efficacy and Safety of Remimazolam and Propofol in Patients Undergoing Elective Surgery Under General Anaesthesia
- Conditions
- Interventions
- First Posted Date
- 2018-09-13
- Last Posted Date
- 2018-09-13
- Lead Sponsor
- R-Pharm
- Target Recruit Count
- 150
- Registration Number
- NCT03669484
- Locations
- 🇷🇺
SBHI City Clinical Hospital №1 n.a. N.I. Pirogov, Moscow, Russian Federation
🇷🇺FSBI Central Clinical Hospital and Polyclinic of Adminisatration of the President of the Russian Federation, Moscow, Russian Federation
🇷🇺SBHI Moscow Clinical Research and Practical center of Department of Healthcare of the city of Moscow, Moscow, Russian Federation
Ketamine Co-induction for Patients With Major Depressive Disorder
- Conditions
- Interventions
- First Posted Date
- 2018-09-11
- Last Posted Date
- 2018-09-13
- Lead Sponsor
- University of Saskatchewan
- Target Recruit Count
- 50
- Registration Number
- NCT03666494
Drug Development Updates
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