Amoxicillin

Generic Name
Amoxicillin
Brand Names
Amoxil, Augmentin, Clavulin, Moxatag, Omeclamox, Prevpac, Talicia, Voquezna 14 Day Dualpak 20;500, Voquezna 14 Day Triplepak 20;500;500
Drug Type
Small Molecule
Chemical Formula
C16H19N3O5S
CAS Number
26787-78-0
Unique Ingredient Identifier
9EM05410Q9
Background

Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.

Amoxicillin was granted FDA approval on 18 January 1974.

Indication

Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections. Amoxicillin is given with omeprazole in the treatment of Helicobacter pylori (H. pylori) infection.

Amoxicillin is used in combination with vonoprazan and clarithromycin as co-packaged triple therapy or in combination with vonoprazan as co-packaged dual therapy to treat H. pylori infection in adults.

Associated Conditions
Acute Bacterial Sinusitis (ABS), Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary tract infection, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections
Associated Therapies
-

Intraluminal Amoxicillin Powder Monotherapy for Helicobacter Pylori Infection

First Posted Date
2018-05-11
Last Posted Date
2019-02-15
Lead Sponsor
Mackay Memorial Hospital
Target Recruit Count
20
Registration Number
NCT03521726
Locations
🇨🇳

Division of Gastroenterology and Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan, Taipei, Taiwan

Penicillin Allergy in Shfayim Clinic

Not Applicable
Conditions
Interventions
First Posted Date
2018-04-17
Last Posted Date
2018-04-17
Lead Sponsor
Clalit Health Services
Target Recruit Count
100
Registration Number
NCT03499457

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of After Administrations of DWP14012 Alone and Combinations of DWP14012, Clarithromycin and Amoxicillin in Healthy Male Subjects

First Posted Date
2018-04-04
Last Posted Date
2019-06-26
Lead Sponsor
Daewoong Pharmaceutical Co. LTD.
Target Recruit Count
48
Registration Number
NCT03487562
Locations
🇰🇷

Seoul National University Hospital, Seoul, Korea, Republic of

The Norwegian Antibiotics for Pneumonia in Children Study

First Posted Date
2018-02-26
Last Posted Date
2018-04-11
Lead Sponsor
Oslo University Hospital
Target Recruit Count
884
Registration Number
NCT03446534
Locations
🇳🇴

Ålesund Hospital Trust, Ålesund, Norway

🇳🇴

Nordlandssykehuset Bodø, Bodø, Norway

🇳🇴

Stavanger University Hospital, Stavanger, Norway

and more 6 locations

Safety Trial of Herbal Melanin in Gastritis Patients

First Posted Date
2018-02-09
Last Posted Date
2018-02-09
Lead Sponsor
King Abdullah International Medical Research Center
Target Recruit Count
132
Registration Number
NCT03428568

Tailored Therapy for Helicobacter Pylori Rescue Treatment

First Posted Date
2018-01-29
Last Posted Date
2018-08-07
Lead Sponsor
Shanghai Jiao Tong University School of Medicine
Target Recruit Count
200
Registration Number
NCT03413020
Locations
🇨🇳

Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China

The Effect of Antibiotic Prophylaxis Associated With Dental Implant Surgery

First Posted Date
2018-01-26
Last Posted Date
2021-08-25
Lead Sponsor
Malmö University
Target Recruit Count
474
Registration Number
NCT03412305
Locations
🇸🇪

Malmö university, Malmö, Sweden

High Dose of Dual Therapy Plus Bismuth for Helicobacter Pylori Treatment

First Posted Date
2018-01-23
Last Posted Date
2018-11-05
Lead Sponsor
Shanghai Jiao Tong University School of Medicine
Target Recruit Count
160
Registration Number
NCT03405584
Locations
🇨🇳

Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China

Oral Challenge in the Pediatric ED

First Posted Date
2018-01-19
Last Posted Date
2024-05-16
Lead Sponsor
Medical College of Wisconsin
Target Recruit Count
116
Registration Number
NCT03404804
Locations
🇺🇸

David Vyles, Milwaukee, Wisconsin, United States

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