Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Effect of Sedative Agent on Reducing the Frequency of Arrhythmia in the Patients After Cardiac Surgery

Not Applicable

Completed

Conditions: Arrythmia

Interventions: Drug: Propofol
Drug: Dexmedetomidine
Drug: Dexmedetomidine and propofol

First Posted Date: 2022-07-08

Last Posted Date: 2022-07-08

Lead Sponsor: Anesthesia Research Group UA

Target Recruit Count: 356

Registration Number: NCT05450497

Locations: 🇺🇦
Medical Network Dobrobut, Kyiv, Ukraine

Comparison of Remimazolam and Dexmedetomidine for Intraoperative Sedation

Phase 4

Completed

Conditions: Orthopedic Disorder

Interventions: Drug: Remimazolam
Drug: Dexmedetomidine

First Posted Date: 2022-07-07

Last Posted Date: 2022-11-29

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 104

Registration Number: NCT05447507

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Jongno-gu, Korea, Republic of

Cardiac Index and General Anesthesia Without Opioid.

Phase 2

Recruiting

Conditions: Hip Arthropathy
Hip Disease

Interventions: Drug: Dexmedetomidine
Drug: Sufentanil

First Posted Date: 2022-07-06

Last Posted Date: 2023-02-08

Lead Sponsor: Centre Hospitalier de Montauban

Target Recruit Count: 120

Registration Number: NCT05446623

Locations: 🇫🇷
Edmundo Pereira de Souza Neto, Montauban, Tarn Et Garonne, France

Intrathecal Morphine Versus Morphine-dexmedetomidine Combination for Postoperative Pain Control After Total Knee Replacement

Not Applicable

Completed

Conditions: Postoperative Pain Control
Intrathecal Morphine-dexmedetomidine Combination
Intrathecal Morphine
Total Knee Replacement

Interventions: Drug: Dexmedetomidine
Drug: Morphine

First Posted Date: 2022-06-30

Last Posted Date: 2023-11-24

Lead Sponsor: Tanta University

Target Recruit Count: 105

Registration Number: NCT05439564

Locations: 🇪🇬
Faculty of Medicine, Tantan University Hospital, Tanta, Egypt

Opioid Free Versus Opioid Based Anaesthesia for Free Flap Reconstruction Surgery of the Breast: A Phase III Multicentric Randomized Controlled Study.

Phase 3

Recruiting

Conditions: Breast Cancer

Interventions: Drug: Dexmedetomidine

First Posted Date: 2022-06-30

Last Posted Date: 2024-04-05

Lead Sponsor: Institut Curie

Target Recruit Count: 158

Registration Number: NCT05439005

Locations: 🇫🇷
Institut Curie Saint-Cloud, Saint-Cloud, France
🇫🇷
Gustave Roussy, Cancer Campus, Grand Paris, Villejuif, France
🇫🇷
Institut Curie Paris, Paris, France

Effect of Intraoperative Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Major Abdominal Surgery

Not Applicable

Recruiting

Conditions: Delirium in Old Age

Interventions: Other: saline
Drug: Dexmedetomidine

First Posted Date: 2022-06-29

Last Posted Date: 2023-09-08

Lead Sponsor: Chinese PLA General Hospital

Target Recruit Count: 300

Registration Number: NCT05436964

Locations: 🇨🇳
Beijing Tiantan Hospital,Capital Medical University, Beijing, China
🇨🇳
Chinese PLA General Hospital, Beijing, China
🇨🇳
Central theater General Hospital, Wuhan, China

Neurochemical Mechanisms of the Awake vs. Anesthetized Brain

Early Phase 1

Conditions: Anesthesia
Healthy

Interventions: Drug: Saline
Drug: Dexmedetomidine

First Posted Date: 2022-06-28

Last Posted Date: 2022-06-28

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 30

Registration Number: NCT05435560

Locations: 🇺🇸
Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States

Dexmedetomidine in Thoracoscopic Surgery: Opioid-Sparing Strategy

Not Applicable

Completed

Conditions: Opioid Use
Postoperative Pain

Interventions: Drug: Dexmedetomidine

First Posted Date: 2022-06-24

Last Posted Date: 2024-01-29

Lead Sponsor: Kaohsiung Veterans General Hospital.

Target Recruit Count: 73

Registration Number: NCT05431322

Locations: 🇨🇳
Kaohsiung Veterans General Hospital, Kaohsiung city, Taiwan

Propofol and Dexmedetomidin vs Midazolam Intraoperative Sedation and POCD

Not Applicable

Recruiting

Conditions: Pertrochanteric Fracture
Postoperative Cognitive Dysfunction
Postoperative Pain, Acute

Interventions: Behavioral: Mini mental state exame (MMSE)
Behavioral: Digit Symbol Substitution Test (DSST)
Diagnostic Test: Numeric rating Scale (NRS)
Diagnostic Test: Postoperative inflammation
Drug: Midazolam
Drug: Propofol
Drug: Dexmedetomidin

First Posted Date: 2022-06-01

Last Posted Date: 2023-07-18

Lead Sponsor: Osijek University Hospital

Target Recruit Count: 80

Registration Number: NCT05398757

Locations: 🇭🇷
University Hospital Osijek, Osijek, Croatia

Analgesic Efficacy of Intravenous Dexmedetomidine for Supraclavicular Plexus Block

Phase 4

Completed

Conditions: Surgery

Interventions: Drug: Dexmedetomidine

First Posted Date: 2022-05-25

Last Posted Date: 2024-02-08

Lead Sponsor: Hôpital du Valais

Target Recruit Count: 100

Registration Number: NCT05389852

Locations: 🇨🇭
Hopital du Valais, Sion, Switzerland

Drug Development Updates

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