Paroxetine

Generic Name
Paroxetine
Brand Names
Paxil, Pexeva
Drug Type
Small Molecule
Chemical Formula
C19H20FNO3
CAS Number
61869-08-7
Unique Ingredient Identifier
41VRH5220H
Background

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham. A unique feature of this...

Indication

Paroxetine is indicated for the management of depression, obsessive-compulsive disorder, panic disorder, social anxiety disorder, generalized anxiety disorder, posttraumatic stress disorder. One form of paroxetine, commercially known as Brisdelle, is used to manage mild to moderate vasomotor symptoms of menopause. Off-label, paroxetine may be used for the tr...

Associated Conditions
Generalized Anxiety Disorder, Irritable Bowel Syndrome (IBS), Major Depressive Disorder (MDD), Obsessive Compulsive Disorder (OCD), Panic Disorder, Post Traumatic Stress Disorder (PTSD), Premature Ejaculation, Premenstrual Dysphoric Disorder (PMDD), Social Anxiety Disorder (SAD), Vasomotor Symptoms Associated With Menopause
Associated Therapies
-
Clinical Trials
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The GRK2 Inhibitor Paroxetine as a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Patients

Phase 1
Active, not recruiting
Conditions
Rheumatoid Arthritis
Interventions
Drug: Placebo
Drug: Paroxetine
First Posted Date
2021-02-17
Last Posted Date
2024-02-01
Lead Sponsor
Sadat City University
Target Recruit Count
100
Registration Number
NCT04757571
Locations
🇪🇬

Faculty of Pharmacy, Shibīn Al Kawm, Menoufia, Egypt

Drug-Drug Interaction Study of HBI-3000 and Paroxetine in Healthy Adult Male and Female Subjects

Phase 1
Completed
Conditions
Drug-drug Interaction
Interventions
Drug: HBI-3000
Drug: Paroxetine
First Posted Date
2020-12-02
Last Posted Date
2022-07-15
Lead Sponsor
HUYABIO International, LLC.
Target Recruit Count
39
Registration Number
NCT04650542
Locations
🇺🇸

Spaulding Clinical, West Bend, Wisconsin, United States

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Nucleus Network Pty Ltd., Melbourne, Victoria, Australia

Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea

First Posted Date
2020-06-24
Last Posted Date
2024-12-09
Lead Sponsor
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Target Recruit Count
370212
Registration Number
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Locations
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Definitive Selection of Neuroimaging Biomarkers for the Diagnosis and Treatment to Common Mental Disorders

First Posted Date
2020-01-06
Last Posted Date
2024-08-21
Lead Sponsor
Central South University
Target Recruit Count
200
Registration Number
NCT04218981
Locations
🇨🇳

The Second Xiangya Hospital of Central South University, Changsha, China

Transcutaneous Posterior Tibial Nerve Stimulation for Premature Ejaculation

First Posted Date
2019-12-23
Last Posted Date
2023-11-01
Lead Sponsor
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Target Recruit Count
120
Registration Number
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🇨🇴

Boston Medical Group, Bogotá, Colombia

Definitive Selection of Neuroimaging Biomarkers in Anxiety Disorder and Obsessive-compulsive Disorder: A Longitudinal Functional Magnetic Resonance Imaging （fMRI） Study With Paroxetine Treatment

Not Applicable
Completed
Conditions
Anxiety Disorder
Obsessive-Compulsive Disorder
Interventions
Drug: Paroxetine
First Posted Date
2019-03-28
Last Posted Date
2024-08-21
Lead Sponsor
Central South University
Target Recruit Count
150
Registration Number
NCT03894085
Locations
🇨🇳

The Second Xiangya Hospital of Central South University, Changsha, China

Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic Assessment

First Posted Date
2018-12-19
Last Posted Date
2023-05-19
Lead Sponsor
Azienda Ospedaliera Universitaria Integrata Verona
Target Recruit Count
362
Registration Number
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Locations
🇮🇹

Azienda Ospedaliera Universitaria Mater Domini, Università Magna Grecia, Catanzaro, Italy

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Sapienza Università di Roma, Dipartimento di Neurologia e Psichiatria, Roma, Italy

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Azienda Ospedaliera Universitaria Verona, Verona, Italy

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

First Posted Date
2018-04-27
Last Posted Date
2024-12-17
Lead Sponsor
Duke University
Target Recruit Count
1600
Registration Number
NCT03511118
Locations
🇺🇸

Northwestern University, Chicago, Illinois, United States

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Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, Illinois, United States

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Loma Linda University Health, Loma Linda, California, United States

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Psycho-biological Substrates of Therapeutic Benefit of Thermal Cure on Generalized Anxiety Disorders

First Posted Date
2017-09-11
Last Posted Date
2022-10-12
Lead Sponsor
Centre Hospitalier Henri Laborit
Target Recruit Count
52
Registration Number
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Centre Hospitalier Henri Laborit, Poitiers, France

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Les thermes de Saujon, Saujon, France

Paroxetine-mediated GRK2 Inhibition to Reduce Cardiac Remodeling After Acute Myocardial Infarction

First Posted Date
2017-09-07
Last Posted Date
2022-06-01
Lead Sponsor
Insel Gruppe AG, University Hospital Bern
Target Recruit Count
50
Registration Number
NCT03274752
Locations
🇨🇭

Bern University Hospital, Department of Cardiology, Bern, Switzerland

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