Clomifene

Generic Name: Clomifene

Brand Names: Clomid

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₂₈ClNO

CAS Number: 911-45-5

Unique Ingredient Identifier: 1HRS458QU2

Background: A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.

Indication: Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation.

Associated Conditions: Ovulatory Dysfunction

Associated Therapies: -

Clinical Trials

Assessing the Efficacy of Clomiphene Citrate in Patients With Azoospermia and Hypoandrogenism

Not Applicable

Withdrawn

Conditions: Non Obstructive Azoospermia
Hypogonadism

Interventions: Drug: Placebo
Drug: Clomiphene

First Posted Date: 2014-05-13

Last Posted Date: 2020-10-05

Lead Sponsor: University of Illinois at Chicago

Registration Number: NCT02137265

Locations: 🇪🇸
University of Valencia, Valencia, Province Of Valencia, Spain

Luteal Phase Versus Follicular Phase Administration of Clomiphene Citrate in PCOS, A Randomized Controlled Trial

Phase 1

Conditions: PCOS

Interventions: Drug: Clomiphene Citrate

First Posted Date: 2013-12-31

Last Posted Date: 2014-03-11

Lead Sponsor: Ain Shams Maternity Hospital

Target Recruit Count: 90

Registration Number: NCT02024984

Locations: 🇪🇬
Ain Shams Maternity Hospital, Cairo, Egypt

Clomiphene Stair-Step Protocol for Ovulation Induction in Women With Polycystic Ovarian Syndrome

Not Applicable

Completed

Conditions: Polycystic Ovary Syndrome

Interventions: Drug: clomiphene

First Posted Date: 2013-10-01

Last Posted Date: 2013-10-01

Lead Sponsor: Kufa University

Target Recruit Count: 140

Registration Number: NCT01953796

Locations: 🇮🇶
Basima Al- Ghazali, Najaf, Kufa, Iraq

Coenzyme Q10 and Clomiphene Citrate (CC) for Ovulation Induction in Polycystic Ovary Syndrome

Not Applicable

Completed

Conditions: Polycystic Ovary Syndrome

Interventions: Drug: Coenzyme Q10
Drug: clomiphene citrate

First Posted Date: 2013-07-30

Last Posted Date: 2013-07-30

Lead Sponsor: Mansoura University

Target Recruit Count: 110

Registration Number: NCT01910766

Locations: 🇪🇬
Mansoura University Hospitals, Mansoura, Dakahlia, Egypt

Clomid in Men With Low Testosterone With and Without Prior Treatment

Phase 2

Completed

Conditions: Hypogonadism, Male

Interventions: Drug: Clomiphene

First Posted Date: 2013-07-22

Last Posted Date: 2021-03-10

Lead Sponsor: Phoenix VA Health Care System

Target Recruit Count: 42

Registration Number: NCT01904734

Locations: 🇺🇸
Phoenix VA Health Care System, Phoenix, Arizona, United States

Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration

Phase 2

Completed

Conditions: Hypogonadism
Opioid-Related Disorders
Male Infertility

Interventions: Drug: Clomiphene citrate
Drug: Placebo

First Posted Date: 2013-06-18

Last Posted Date: 2018-07-17

Lead Sponsor: Weill Medical College of Cornell University

Target Recruit Count: 13

Registration Number: NCT01880086

Locations: 🇺🇸
Weill Cornell Medical College, Department of Urology, New York, New York, United States

Impact of Clomiphene Citrate Administration During the Early Luteal Phase on Endocrine Profile in IVF Cycles

Phase 4

Completed

Conditions: Female Infertility

Interventions: Drug: Clomifene Citrate

First Posted Date: 2013-02-15

Last Posted Date: 2013-02-15

Lead Sponsor: Fundació Privada Eugin

Target Recruit Count: 10

Registration Number: NCT01791751

Locations: 🇪🇸
Clínica EUGIN, Barcelona, Spain

Progestin-induced Endometrial Shedding in PCOS (The PIES in PCOS Study)

Not Applicable

Terminated

Conditions: Polycystic Ovary Syndrome
Infertility

Interventions: Drug: Progestin
Drug: Clomiphene Citrate

First Posted Date: 2012-10-31

Last Posted Date: 2020-09-29

Lead Sponsor: University of Illinois at Chicago

Target Recruit Count: 27

Registration Number: NCT01718444

Locations: 🇺🇸
University of Illinois at Chicago, Chicago, Illinois, United States

Letrozole or Combined Clomiphene Citrate Metformin as a First Line Treatment in Women With Polycystic Ovarian Syndrome

Not Applicable

Completed

Conditions: Polycystic Ovary Syndrome

Interventions: Drug: Clomiphene
Drug: Letrozole
Drug: Metformin

First Posted Date: 2012-09-06

Last Posted Date: 2012-09-07

Lead Sponsor: Assiut University

Target Recruit Count: 200

Registration Number: NCT01679574

Locations: 🇪🇬
Assiut University, Assiut, Egypt

Clomifene Citrate Versus Metformin in First-line Treatment of Infertility in Patients With Polycystic Ovary Syndrome and a Resistance to Insulin

Phase 3

Withdrawn

Conditions: Polycystic Ovary Syndrome
Insulin Resistance

Interventions: Drug: Metformin
Drug: Clomiphene citrate

First Posted Date: 2012-07-12

Last Posted Date: 2015-07-28

Lead Sponsor: Clinique Ovo

Registration Number: NCT01638988

Locations: 🇨🇦
Clinique Ovo, Montréal, Quebec, Canada

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