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Enfortumab Vedotin and Pembrolizumab Followed by Cystectomy And/or Ureterectomy for the Treatment of Locally Advanced or Metastatic Bladder and Upper Urothelial Tract Cancer, CAST-AI Trial

Phase 4
Not yet recruiting
Conditions
Locally Advanced Bladder Urothelial Carcinoma
Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma
Metastatic Bladder Urothelial Carcinoma
Metastatic Renal Pelvis and Ureter Urothelial Carcinoma
Stage III Bladder Cancer AJCC V8
Stage IV Bladder Cancer AJCC V8
Stage IV Renal Pelvis and Ureter Cancer AJCC V8
Interventions
Procedure: Biospecimen Collection
Procedure: Computed Tomography
Procedure: Cystectomy
Drug: Enfortumab Vedotin
Procedure: Local Therapy
Procedure: Magnetic Resonance Imaging
Biological: Pembrolizumab
Procedure: Positron Emission Tomography
Other: Questionnaire Administration
Procedure: Ureterectomy
First Posted Date
2025-01-08
Last Posted Date
2025-01-08
Lead Sponsor
Mayo Clinic
Target Recruit Count
75
Registration Number
NCT06764095
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis

Phase 4
Recruiting
Conditions
Cystectomy
Bladder Cancer Requiring Cystectomy
Postoperative Infections
Antibiotic Prophylaxis
Ileal Conduit
Interventions
First Posted Date
2024-11-29
Last Posted Date
2025-01-09
Lead Sponsor
Rigshospitalet, Denmark
Target Recruit Count
248
Registration Number
NCT06709196
Locations
🇩🇰

Department of Urology, Aalborg University Hospital, Aalborg, Denmark

🇩🇰

Department of Urology, Aarhus University Hospital, Aarhus, Denmark

🇩🇰

Department of Urology, Rigshospitalet, Copenhagen, Denmark

and more 2 locations

A Study of Surgical Techniques During Cystectomy

Phase 3
Recruiting
Conditions
Bladder Cancer
Interventions
Procedure: Stent placement
Drug: Alvimopan
First Posted Date
2024-11-25
Last Posted Date
2024-11-25
Lead Sponsor
Memorial Sloan Kettering Cancer Center
Target Recruit Count
530
Registration Number
NCT06703476
Locations
🇺🇸

Memorial Sloan Kettering at Basking Ridge (Consent Only), Basking Ridge, New Jersey, United States

🇺🇸

Memorial Sloan Kettering Monmouth (Consent Only), Middletown, New Jersey, United States

🇺🇸

Memorial Sloan Kettering Bergen (Consent Only), Montvale, New Jersey, United States

and more 4 locations

Better in Better Out Cystectomy.

Not yet recruiting
Conditions
Bladder Cancer
First Posted Date
2024-11-19
Last Posted Date
2024-11-19
Lead Sponsor
Ziekenhuis Oost-Limburg
Target Recruit Count
100
Registration Number
NCT06694649

Chlorhexidine Antiseptic Irrigation of the Bowel Segment During Radical Cystectomy and Urinary Diversion

Not Applicable
Recruiting
Conditions
Bladder Cancer
Urinary Tract Infection
First Posted Date
2024-11-14
Last Posted Date
2024-11-14
Lead Sponsor
Icahn School of Medicine at Mount Sinai
Target Recruit Count
40
Registration Number
NCT06689176
Locations
🇺🇸

Mount Sinai Hospital, New York, New York, United States

A Feasibility Randomized Trial Evaluating Early Vs Late Stent Removal Following Radical Cystectomy and Ileal Conduit Formation for Bladder Cancer

Not Applicable
Not yet recruiting
Conditions
Bladder Cancer Requiring Cystectomy
Ileal Conduit
Urinary Diversion
Interventions
Procedure: Early Stent removal
Procedure: Late Stent removal
First Posted Date
2024-09-13
Last Posted Date
2024-09-19
Lead Sponsor
Western University, Canada
Target Recruit Count
60
Registration Number
NCT06595446
Locations
🇨🇦

Victoria Hospital, London, Ontario, Canada

Comprehensive Geriatric Assessment (Tests) for Bladder Cancer Participants Undergoing Radical Cystectomy

Not Applicable
Recruiting
Conditions
Bladder Cancer
Interventions
Other: Educational Video Modules on Risk Prevention Before and After Cystectomy (Surgery)
Other: Geriatric Service/ Discharge Planning
Other: Questionnaires
First Posted Date
2024-05-24
Last Posted Date
2024-08-16
Lead Sponsor
University of Chicago
Target Recruit Count
85
Registration Number
NCT06427824
Locations
🇺🇸

University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois, United States

Erector Spinae Plane Block in Radical Cystectomy

Not Applicable
Completed
Conditions
Erector Spinae Plane Block
Radical Cystectomy
Interventions
Drug: Bupivacain 25% (Erector Spinae Plane Block)
Drug: Morphine (Intravenous patient-controlled analgesia)
First Posted Date
2024-05-20
Last Posted Date
2024-05-21
Lead Sponsor
Kafrelsheikh University
Target Recruit Count
60
Registration Number
NCT06422182
Locations
🇪🇬

Kafrelsheikh University, Kafr Ash Shaykh, Kafrelsheikh, Egypt

Hemostatic Measures During Laparoscopic Cystectomy for Endometrioma

Not Applicable
Completed
Conditions
Endometrioma
Interventions
Procedure: bipolar electrocoagulation
Procedure: suturing
First Posted Date
2024-05-20
Last Posted Date
2024-05-20
Lead Sponsor
Ain Shams Maternity Hospital
Target Recruit Count
48
Registration Number
NCT06421857
Locations
🇪🇬

Ain Shams university, Cairo, Egypt

Preoperative Physical Activity Improvement With the Use of Activity Trackers Before Radical Cystectomy (PreAct)

Not Applicable
Recruiting
Conditions
Bladder Neoplasm
Bladder Cancer
Bladder Urothelial Carcinoma
Interventions
Device: Daily Activity Goal and Feedback
First Posted Date
2024-05-16
Last Posted Date
2024-05-16
Lead Sponsor
Universitätsmedizin Mannheim
Target Recruit Count
164
Registration Number
NCT06416319
Locations
🇩🇪

Urologische Klinik München Planegg (UKMP), München, Bayern, Germany

🇩🇪

Department of Urology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Baden-Württemberg, Germany

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