Sevoflurane

Generic Name: Sevoflurane

Brand Names: Sevorane, Sojourn, Ultane

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃F_₇O

CAS Number: 28523-86-6

Unique Ingredient Identifier: 38LVP0K73A

Background: Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.

Indication: Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Associated Conditions: -

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia

Clinical Trials

Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function

Phase 4

Completed

Conditions: Cerebral Arterial Aneurysm

Interventions: Drug: propofol postconditioning
Drug: sevoflurane

First Posted Date: 2016-02-25

Last Posted Date: 2017-07-11

Lead Sponsor: The Third Central Clinical College of Tianjin Medical University

Target Recruit Count: 60

Registration Number: NCT02691416

Comparison of the Effects of TIVA vs VIMA on Content of GSK-3beta in Leucocytes in On-pump Patients

Phase 4

Terminated

Conditions: Glycogen Synthase Kinase 3

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2016-02-19

Last Posted Date: 2019-08-15

Lead Sponsor: Moscow Regional Research and Clinical Institute (MONIKI)

Target Recruit Count: 10

Registration Number: NCT02686710

Locations: 🇷🇺
Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy, Moscow, Russian Federation

Pupillometry Guided Remifentanil Administration In Pediatric Anesthesia

Not Applicable

Withdrawn

Conditions: Pain
Anesthesia
Child

Interventions: Drug: Remifentanil
Device: Pupillometry
Drug: Sevoflurane

First Posted Date: 2016-02-17

Last Posted Date: 2024-04-18

Lead Sponsor: University Hospital, Geneva

Registration Number: NCT02683837

Locations: 🇨🇭
Geneva Children's Hospital, Geneva, Switzerland

Systemic Inflammatory Response Evaluation With the Use of Inhaled Anesthetic Sevoflurane During CPB

Completed

Conditions: Inflammatory Response

Interventions: Drug: Sevoflurane

First Posted Date: 2016-02-03

Last Posted Date: 2020-06-23

Lead Sponsor: Instituto Dante Pazzanese de Cardiologia

Target Recruit Count: 100

Registration Number: NCT02672345

Locations: 🇧🇷
Thiago Augusto Azevedo Maranhão Cardoso, São Paulo, Brazil

Sevoflurane and Percutaneous Coronary Intervention by Stent

Phase 4

Terminated

Conditions: Myocardial Infarction

Interventions: Drug: sevoflurane

First Posted Date: 2016-02-02

Last Posted Date: 2020-04-28

Lead Sponsor: Instituto Dante Pazzanese de Cardiologia

Target Recruit Count: 701

Registration Number: NCT02671084

Locations: 🇧🇷
Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil

Anesthetic Techniques in EP Patients

Phase 4

Terminated

Conditions: Cardiac Disease

Interventions: Drug: Propofol
Drug: Sevoflurane
Drug: Ketamine
Drug: Remifentanil

First Posted Date: 2016-01-27

Last Posted Date: 2020-09-22

Lead Sponsor: University of California, Los Angeles

Target Recruit Count: 35

Registration Number: NCT02664922

Locations: 🇺🇸
Ronald Reagan UCLA Medical Center, Los Angeles, California, United States

Impact of Anesthesia Maintenance Methods on Incidence of Postoperative Delirium

Not Applicable

Completed

Conditions: Delirium
Postoperative Complications
Postoperative Cognitive Dysfunction

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2016-01-25

Last Posted Date: 2022-03-04

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 1228

Registration Number: NCT02662257

Locations: 🇨🇳
Cancer Hospital of Guangxi Medical University, Nanning, Guangxi, China
🇨🇳
Peking University Cancer Hospital, Beijing, Beijing, China
🇨🇳
Peking University School and Hospital of Stomatology, Beijing, Beijing, China

and more 14 locations

Impact of Anesthesia Maintenance Methods on Long-term Survival

Not Applicable

Completed

Conditions: Aged
Neoplasms
Surgical Procedure, Operative
Anesthesia, Inhalation
Anesthesia, Intravenous
Survival

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2016-01-21

Last Posted Date: 2022-03-04

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 1228

Registration Number: NCT02660411

Locations: 🇨🇳
Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing, Beijing, China
🇨🇳
Guizhou Provincial People's Hospital, Guiyang, Guizhou, China
🇨🇳
Hebei Medical University Forth Hospital, Shijiazhuang, Hebei, China

and more 14 locations