Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Single Shot Intrathecal Analgesia in Vaginal Delivery
- Conditions
- Effectiveness of Single Shot Intra-thecal Analgesia in Multiparous Women Scheduled for Normal Vaginal Delivery
- Interventions
- First Posted Date
- 2023-08-21
- Last Posted Date
- 2023-08-21
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 75
- Registration Number
- NCT05998551
- Locations
- 🇪🇬
Ainshams University, Cairo, Egypt
Evaluation of the Postoperative Agitation Prevention and Analgesic Efficacy of Perioperative Dexmedetomidine Infusion in a Pediatric Patient Group to Undergo Tonsillectomy and Adenoidectomy
- Conditions
- AnxietyPostoperative PainBleeding
- Interventions
- First Posted Date
- 2023-08-14
- Last Posted Date
- 2023-11-08
- Lead Sponsor
- Burak Omur
- Target Recruit Count
- 80
- Registration Number
- NCT05986942
- Locations
- 🇹🇷
Istanbul Medipol University, Istanbul, Turkey
Paracetamol Plus Tramadol Versus Fentanyl in Day Case Surgeries
- Conditions
- Post Operative Pain
- Interventions
- First Posted Date
- 2023-08-14
- Last Posted Date
- 2024-02-28
- Lead Sponsor
- Zagazig University
- Target Recruit Count
- 132
- Registration Number
- NCT05990686
- Locations
- 🇪🇬
Zagazig University , Fuculty of Medicine, Zagazig, Sharquia, Egypt
Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty
- Conditions
- Genicular Nerve BlockOpioid UseTotal Knee Replacement
- Interventions
- First Posted Date
- 2023-08-08
- Last Posted Date
- 2024-12-27
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 244
- Registration Number
- NCT05980546
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
Hemodynamic Effects of Bolus of Ketamine Versus Fentanyl in Patients With Septic Shock
- Conditions
- FentanylSeptic ShockKetamine
- Interventions
- First Posted Date
- 2023-07-24
- Last Posted Date
- 2023-12-22
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 86
- Registration Number
- NCT05957302
- Locations
- 🇪🇬
Ahmed Mohamed Hasanin, Cairo, Egypt
Symptom-inhibited Fentanyl Induction
- Conditions
- Opioid Use Disorder
- Interventions
- First Posted Date
- 2023-06-15
- Last Posted Date
- 2024-07-18
- Lead Sponsor
- Pouya Azar
- Target Recruit Count
- 50
- Registration Number
- NCT05905367
- Locations
- 🇨🇦
Hope to Health Research & Innovation Centre, Vancouver, British Columbia, Canada
Comparison of Patient-controlled Analgesia Regimenfor Postoperative Pain in Patients Undergoing Total Knee Arthroplasty
- Conditions
- Postoperative Pain, Acute
- Interventions
- First Posted Date
- 2023-05-17
- Last Posted Date
- 2024-07-15
- Lead Sponsor
- Chung-Ang University Gwangmyeong Hospital
- Target Recruit Count
- 98
- Registration Number
- NCT05861791
- Locations
- 🇰🇷
ChungAng University Gwangmyeong Hospital, Gyeonggi-do, Gwangmyeon-si, Korea, Republic of
A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle
- Conditions
- Respiratory Function LossRespiratory Complication
- Interventions
- First Posted Date
- 2023-05-12
- Last Posted Date
- 2024-07-12
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 200
- Registration Number
- NCT05856136
- Locations
- 🇺🇸
Mayo Clinic Minnesota, Rochester, Minnesota, United States
Effectiveness of Combining Erector Spinea Block With Non Opioid Infusions as Opioid Free Anesthesia in Spine Surgeries.
- Conditions
- Opioid UseSpine Fusion
- Interventions
- First Posted Date
- 2023-05-09
- Last Posted Date
- 2023-05-09
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 140
- Registration Number
- NCT05850468
- Locations
- 🇪🇬
Ainshams hospitals, Cairo, Egypt
Efficacy of Erector Spinae Plane Block Analgesia After Off Pump Cardiac Surgery
- Conditions
- Postoperative Pain
- Interventions
- Procedure: Erector spinae block
- First Posted Date
- 2023-03-15
- Last Posted Date
- 2024-03-19
- Lead Sponsor
- Menoufia University
- Target Recruit Count
- 50
- Registration Number
- NCT05769309
- Locations
- 🇪🇬
Menoufia university, Cairo, Shibin Elkom, Egypt
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.