Scopolamine

Generic Name: Scopolamine

Brand Names: Donnatal, Phenohytro, Transderm Scop

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₁NO_₄

CAS Number: 51-34-3

Unique Ingredient Identifier: DL48G20X8X

Background: Scopolamine is a tropane alkaloid isolated from members of the Solanaceae family of plants, similar to atropine and hyoscyamine, all of which structurally mimic the natural neurotransmitter acetylcholine. Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine analo...

Indication: Scopolamine is indicated in adult patients for the prevention of nausea and vomiting associated with motion sickness and for the prevention of postoperative nausea and vomiting (PONV) associated with anesthesia or opiate analgesia.

Associated Conditions: Motion Sickness, Post Operative Nausea and Vomiting (PONV)

Associated Therapies: Anesthetic premedication therapy

Clinical Trials

TAK-071 Scopolamine-Induced Cognitive Impairment Study

Phase 1

Terminated

Conditions: Healthy Volunteers

Interventions: Drug: Scopolamine
Drug: TAK-071
Drug: Donepezil
Drug: Scopolamine Placebo
Drug: TAK-071 Placebo
Drug: Donepezil Placebo

First Posted Date: 2016-09-28

Last Posted Date: 2019-06-14

Lead Sponsor: Takeda

Target Recruit Count: 18

Registration Number: NCT02918266

Observational Prospective Study to Evaluate AEs, Risk Factors and Drug Utilization of BUSCAPINA COMPOSITUM N in Adults From Metropolitan Lima

Completed

Conditions: Acute Pain
Dysmenorrhea

Interventions: Drug: Hyoscine n-butylbromide
Drug: Paracetamol

First Posted Date: 2016-09-21

Last Posted Date: 2019-03-27

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 360

Registration Number: NCT02910167

The Application of Spasmolytic in PCLE Examination of Superior Gastrointestinal Endoscope

Phase 1

Completed

Conditions: Using Copolamine Butylbromide in Probe-based Confocal Laser Endomicroscopy for Gastroendoscopy Examination

Interventions: Drug: normal saline
Drug: Scopolamine Hydrobromide

First Posted Date: 2016-06-23

Last Posted Date: 2016-06-23

Lead Sponsor: Shandong University

Target Recruit Count: 122

Registration Number: NCT02811341

Locations: 🇨🇳
Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong, China

Effect of Buscopan on Gastrointestinal Imaging Quality With Probe-based Confocal Laser Endomicroscopy

Not Applicable

Conditions: Gastrointestinal Imaging With pCLE

Interventions: Drug: physiological saline
Drug: Buscopan
Drug: Scopolamine

First Posted Date: 2016-04-01

Last Posted Date: 2016-04-01

Lead Sponsor: Xijing Hospital of Digestive Diseases

Target Recruit Count: 150

Registration Number: NCT02725398

Locations: 🇨🇳
Xijing Hospital of Digestive Diseases, Xi'an, Shaanxi, China

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Not Applicable

Completed

Conditions: Postoperative Nausea and Vomiting

Interventions: Procedure: Automated recommendation at the start of the case
Procedure: Automated notification at the start of surgery
Procedure: Automated notification at the end of surgery
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Procedure: Elective surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Isoflurane
Drug: Desflurane
Drug: Scopolamine
Drug: Droperidol
Drug: Haloperidol
Drug: Dexamethasone
Drug: Promethazine
Drug: Meclizine
Drug: Aprepitant
Drug: Metoclopramide
Drug: Fentanyl
Drug: Sufentanil
Drug: Alfentanil
Drug: Remifentanil
Drug: Morphine
Drug: Meperidine
Drug: Hydromorphone
Drug: Methadone
Drug: Oxycodone
Drug: Oxymorphone
Drug: Hydrocodone
Drug: Ketamine
Drug: Ondansetron
Drug: Granisetron
Drug: Dolasetron mesylate
Drug: Palonosetron
Drug: Tropisetron
Drug: Ramosetron

First Posted Date: 2015-12-09

Last Posted Date: 2019-03-07

Lead Sponsor: Vanderbilt University

Target Recruit Count: 27034

Registration Number: NCT02625181

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Clozapine-induced Hypersalivation - Feasibility Trial

Phase 1

Completed

Conditions: Sialorrhea

Interventions: Drug: Hyoscine
Other: Placebo
Drug: Glycopyrrolate

First Posted Date: 2015-11-24

Last Posted Date: 2018-02-28

Lead Sponsor: Mersey Care NHS Trust

Target Recruit Count: 29

Registration Number: NCT02613494

Locations: 🇬🇧
Lancashire Care NHS Foundation Trust, Preston, Lancashire, United Kingdom
🇬🇧
Mersey Care NHS Trust, Liverpool, Merseyside, United Kingdom