Phenylephrine

Generic Name
Phenylephrine
Brand Names
4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain
Drug Type
Small Molecule
Chemical Formula
C9H13NO2
CAS Number
59-42-7
Unique Ingredient Identifier
1WS297W6MV
Background

Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.

Phenylephrine was granted FDA approval in 1939.

Indication

Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids. Off-label uses include priapism and induction of local vasoconstriction.

Associated Conditions
Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes
Associated Therapies
Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy
Clinical Trials
Related News

Effects of Phenylephrine on Cardiac Preload

Phase 4
Completed
Conditions
Anaesthesia
Arterial Hypotension
Interventions
Drug: Phenylephrine
First Posted Date
2016-04-15
Last Posted Date
2016-12-09
Lead Sponsor
Algemeen Ziekenhuis Maria Middelares
Target Recruit Count
26
Registration Number
NCT02739399
Locations
🇧🇪

AZ Maria Middelares, Gent, Belgium

Decision Support for Intraoperative Low Blood Pressure

Not Applicable
Completed
Conditions
Hypotension
Interventions
Procedure: Attending real-time decision support
Procedure: In-room real-time decision support
Procedure: Attending feedback emails
Procedure: In-room provider feedback emails
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Device: Pager system
Procedure: Central neuraxial anesthesia
Procedure: Non-cardiac surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Desflurane
Drug: Isoflurane
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
Drug: Epinephrine
Drug: Dobutamine
Drug: Dopamine
Drug: Isoproterenol
Drug: Milrinone
Drug: Atropine
Drug: Glycopyrrolate
Drug: Vasopressin
Drug: Terlipressin
Drug: Sodium Chloride 0.9%
Drug: Ringer's lactate
Drug: Hydroxyethyl starch solutions
Drug: Fresh Frozen Plasma
Drug: Packed Red Blood Cells
Drug: Albumin solutions
Drug: Plasma-Lyte
Drug: Lidocaine
Drug: Bupivacaine
Drug: Levobupivacaine
Drug: Ropivacaine
Drug: Mepivacaine
Drug: Tetracaine
Drug: Prilocaine
Drug: Procaine
Drug: Chloroprocaine
Drug: Benzocaine
Drug: Articaine
First Posted Date
2016-04-04
Last Posted Date
2019-05-16
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
22435
Registration Number
NCT02726620
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Autoimmune Basis for Postural Tachycardia Syndrome

First Posted Date
2016-03-31
Last Posted Date
2024-11-06
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
58
Registration Number
NCT02725060
Locations
🇺🇸

Autonomic Dysfunction Center, Nashville, Tennessee, United States

🇺🇸

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Vasopressor Effects in Anesthetized Patients

Phase 4
Completed
Conditions
Brain Tumor
Interventions
Drug: Ephedrine
Drug: Phenylephrine
First Posted Date
2016-03-18
Last Posted Date
2018-10-26
Lead Sponsor
University of Aarhus
Target Recruit Count
48
Registration Number
NCT02713087
Locations
🇩🇰

Aarhus University Hospital, Aarhus, Jylland, Denmark

Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients

First Posted Date
2016-03-08
Last Posted Date
2019-08-28
Lead Sponsor
NYU Langone Health
Target Recruit Count
66
Registration Number
NCT02701582
Locations
🇺🇸

New York University School of Medicine, New York, New York, United States

Effects of Vasopressors on Immune Response

First Posted Date
2016-02-05
Last Posted Date
2016-10-13
Lead Sponsor
Radboud University Medical Center
Target Recruit Count
40
Registration Number
NCT02675868
Locations
🇳🇱

Radboudumc, Nijmegen, Gelderland, Netherlands

POTS Adrenergic Ab (CIHR Aims #1&2)

First Posted Date
2016-02-04
Last Posted Date
2024-05-08
Lead Sponsor
University of Calgary
Target Recruit Count
125
Registration Number
NCT02673996
Locations
🇨🇦

University of Calgary, Calgary, Alberta, Canada

The Effects of Height and Weight Adjusted Dose of Local Anesthetic.

Not Applicable
Completed
Conditions
Hypotension
Complications; Cesarean Section
Interventions
Drug: Phenylephrine
First Posted Date
2015-12-21
Last Posted Date
2022-09-26
Lead Sponsor
Lawson Health Research Institute
Target Recruit Count
160
Registration Number
NCT02635555
Locations
🇨🇦

Victoria Hospital, London, Ontario, Canada

Effect of Phenylephrine During Shoulder Arthroscopic Surgery

Not Applicable
Completed
Conditions
Disorder of Shoulder
Anesthesia
Interventions
Drug: Phenylephrine
First Posted Date
2015-10-23
Last Posted Date
2016-11-01
Lead Sponsor
Inje University
Target Recruit Count
66
Registration Number
NCT02585570
Locations
🇰🇷

Haeundae paik hospital, inje university, Busan, Korea, Republic of

Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV

First Posted Date
2015-09-25
Last Posted Date
2024-02-14
Lead Sponsor
Emory University
Target Recruit Count
134
Registration Number
NCT02560805
Locations
🇺🇸

Atlanta VA Medical Center, Decatur, Georgia, United States

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