DeepMed Research

Lithium cation

Generic Name: Lithium cation

Drug Type: Small Molecule

Chemical Formula: Li

CAS Number: 7439-93-2

Unique Ingredient Identifier: 8H8Z5UER66

Background: Lithium was used during the 19th century to treat gout. Lithium salts such as lithium carbonate (Li2CO3), lithium citrate, and lithium orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. Lithium can also be used to augment other antidepressant drugs. It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several critical neuronal enzymes and neurotransmitter receptors.

Indication: Lithium, in its salt forms, is used as a mood stabilizer and for the treatment of depression and mania. It is most frequently prescribed in the treatment of bipolar disorder.

Associated Conditions: Bipolar Disorder (BD), Depression, Depression, Bipolar, Acute Manic episode

Clinical Trials

Lithium Effects on Reward Processing and Reappraisal in Healthy Volunteers

Not Applicable

Completed

Conditions: Healthy

Interventions: Other: Placebo - Rayotabs
Drug: Lithium

First Posted Date: 2019-05-28

Last Posted Date: 2019-05-28

Lead Sponsor: University of Oxford

Target Recruit Count: 37

Registration Number: NCT03965247

Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

Recruiting

Conditions: Bipolar Disorder
Major Depressive Episode
Bipolar II Depression
Bipolar I Depression
Depression
Bipolar Depression

Interventions: Drug: Lithium

First Posted Date: 2017-11-08

Last Posted Date: 2024-04-08

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 120

Registration Number: NCT03336918

Locations: 🇺🇸
Cleveland Clinic Foundation Center for Behavioral Health, Cleveland, Ohio, United States

Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving Ketamine

Phase 2

Withdrawn

Conditions: Treatment Resistant Depression

Interventions: Drug: Lithium
Drug: Placebo
Drug: Ketamine

First Posted Date: 2017-09-25

Last Posted Date: 2018-08-16

Lead Sponsor: William V. Bobo, M.D.

Registration Number: NCT03290963

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Dose Escalation Study of Lithium With Oxaliplatin and Capecitabine in Advanced Oesophago-Gastric or Colorectal Cancer

Phase 1

Active, not recruiting

Conditions: Colorectal Neoplasms
Stomach Neoplasm
Esophageal Neoplasms

Interventions: Drug: Lithium
Drug: Oxaliplatin
Drug: Capecitabine

First Posted Date: 2017-05-15

Last Posted Date: 2023-10-13

Lead Sponsor: Cancer Trials Ireland

Target Recruit Count: 2

Registration Number: NCT03153280

Locations: 🇮🇪
St James's Hospital, Dublin 8, Ireland
🇮🇪
Cork University Hospital, Cork, Ireland

Lithium Versus Quetiapine in Treatment Resistant Depression

Phase 4

Conditions: Depressive Disorder, Treatment-Resistant

Interventions: Drug: Lithium
Drug: Quetiapine

First Posted Date: 2016-12-29

Last Posted Date: 2021-03-05

Lead Sponsor: King's College London

Target Recruit Count: 276

Registration Number: NCT03004521

Locations: 🇬🇧
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom

Gao NARASD Lithium Study

Phase 4

Terminated

Conditions: Bipolar Disorder

Interventions: Drug: Lithium

First Posted Date: 2016-09-21

Last Posted Date: 2020-07-10

Lead Sponsor: Keming Gao

Target Recruit Count: 24

Registration Number: NCT02909504

Locations: 🇺🇸
University Hospitals Cleveland Medical Center Department of Psychiatry, Cleveland, Ohio, United States

Cost- Effectiveness and Quality of Life Assessment in Major Depression Disorder

Phase 4

Completed

Conditions: Depression

Interventions: Drug: sertraline
Drug: Nortriptyline
Drug: Lithium

First Posted Date: 2016-09-15

Last Posted Date: 2020-10-14

Lead Sponsor: Federal University of Rio Grande do Sul

Target Recruit Count: 68

Registration Number: NCT02901249

Cost- Effectiveness and Quality of Life Assessment in Mood Disorder

Phase 4

Completed

Conditions: Bipolar Disorder

Interventions: Drug: Lithium
Drug: Valproic Acid
Drug: Carbamazepine

First Posted Date: 2016-08-17

Last Posted Date: 2020-11-20

Lead Sponsor: Federal University of Rio Grande do Sul

Target Recruit Count: 107

Registration Number: NCT02870283

Lithium Therapy: Understanding Mothers, Metabolism and Mood

Completed

Conditions: Bipolar Disorder

First Posted Date: 2015-07-03

Last Posted Date: 2022-10-05

Lead Sponsor: Northwestern University

Target Recruit Count: 9

Registration Number: NCT02490241

Locations: 🇺🇸
Northwestern Memorial Hospital, Chicago, Illinois, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3

Terminated

Conditions: Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders

Interventions: Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium

First Posted Date: 2015-03-02

Last Posted Date: 2018-02-28

Lead Sponsor: Hannover Medical School

Target Recruit Count: 407

Registration Number: NCT02374567

Locations: 🇩🇪
Bezirkskrankenhaus Augsburg, Augsburg, Germany
🇩🇪
Krankenhaus Hedwigshöhe, Berlin, Germany
🇩🇪
Hannover Medical School, Hannover, Germany

and more 2 locations

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

© Copyright 2025. All Rights Reserved by MedPath

Home Terms & Conditions Privacy Policy