Articaine

Generic Name: Articaine

Brand Names: Articadent, Astracaine, Orabloc, Septanest, Septocaine, Ultacan, Ultracaine, Zorcaine

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₂₀N_₂O_₃S

CAS Number: 23964-58-1

Unique Ingredient Identifier: D3SQ406G9X

Background: Articaine is a dental local anesthetic. Articaine is widely used around the world and is the most popular local anesthetic in many European countries.

Associated Conditions: -

Associated Therapies: Dental Local Anesthesia

Clinical Trials

Articaine Plus Dexmedetomidine in Supraclavicular Block

Not Applicable

Recruiting

Conditions: Post Operative Pain, Acute

Interventions: Drug: Articaine
Drug: Dexmedetomidine

First Posted Date: 2024-05-21

Last Posted Date: 2024-05-23

Lead Sponsor: Benha University

Target Recruit Count: 66

Registration Number: NCT06423859

Locations: 🇪🇬
Samar Rafik Mohamed Amin, Banhā, Qalubia, Egypt

Self-Reported Pain in Children Submitted to Single Infiltration of Articaine During Primary Molar Extraction

Phase 4

Completed

Conditions: Dental Pain
Anesthesia, Local

Interventions: Drug: Articaine
Drug: Lidocaine

First Posted Date: 2022-07-05

Last Posted Date: 2024-11-25

Lead Sponsor: Universidade Federal de Santa Catarina

Target Recruit Count: 76

Registration Number: NCT05443009

Locations: 🇧🇷
Centro de Especialidades Odontológicas (CEO), São José, Brazil
🇧🇷
Universidade Federal de Santa Catarina - USFC, Santa Catarina, Brazil

Anaesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine With Symptomatic Irreversible Pulpitis

Not Applicable

Completed

Conditions: Symptomatic Irreversible Pulpitis

Interventions: Drug: Mepivacaine
Drug: Articaine

First Posted Date: 2021-03-30

Last Posted Date: 2021-08-02

Lead Sponsor: Cairo University

Target Recruit Count: 330

Registration Number: NCT04822415

A Comparison of 4% Articaine Versus 0.5%Bupivacaine for Ambulatory Surgery Under Supraclavicular Block

Phase 1

Completed

Conditions: Upper Limb Surgery
Hand Surgery

Interventions: Drug: Articaine
Drug: Bupivacaine

First Posted Date: 2019-12-06

Last Posted Date: 2020-04-28

Lead Sponsor: Ain Shams University

Target Recruit Count: 60

Registration Number: NCT04189198

Locations: 🇪🇬
Ain Shams University hosptal, Cairo, Abbasya, Egypt

Articaine vs Dexmedetomidine Supplemented Articaine

Early Phase 1

Completed

Conditions: Renal Failure

Interventions: Drug: Articaine
Drug: Dexmedetomidine

First Posted Date: 2019-11-20

Last Posted Date: 2019-11-20

Lead Sponsor: Ain Shams University

Target Recruit Count: 50

Registration Number: NCT04171349

Locations: 🇪🇬
Ain Shams University hosptal, Cairo, Abbasya, Egypt

Anesthetic Efficacy Of 4% ArtpharmaDent Versus 2% Mepecaine-L in Extraction of Lower First Primary Molars

Not Applicable

Conditions: Badly Decayed Lower First Primary Molars in Children

Interventions: Drug: articaine
Drug: Mepivacaine 2% Injection

First Posted Date: 2019-05-08

Last Posted Date: 2019-08-29

Lead Sponsor: Cairo University

Target Recruit Count: 20

Registration Number: NCT03942991

Articaine vs Lidocaine for Pediatric Dental Procedures

Phase 4

Withdrawn

Conditions: Anesthesia, Dental
Pain, Postoperative

Interventions: Drug: lidocaine
Drug: articaine

First Posted Date: 2017-10-24

Last Posted Date: 2022-11-03

Lead Sponsor: Boston University

Registration Number: NCT03318952

Locations: 🇺🇸
BU Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, United States

Decision Support for Intraoperative Low Blood Pressure

Not Applicable

Completed

Conditions: Hypotension

Interventions: Procedure: Attending real-time decision support
Procedure: In-room real-time decision support
Procedure: Attending feedback emails
Procedure: In-room provider feedback emails
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Device: Pager system
Procedure: Central neuraxial anesthesia
Procedure: Non-cardiac surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Desflurane
Drug: Isoflurane
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
Drug: Epinephrine
Drug: Dobutamine
Drug: Dopamine
Drug: Isoproterenol
Drug: Milrinone
Drug: Atropine
Drug: Glycopyrrolate
Drug: Vasopressin
Drug: Terlipressin
Drug: Sodium Chloride 0.9%
Drug: Ringer's lactate
Drug: Hydroxyethyl starch solutions
Drug: Fresh Frozen Plasma
Drug: Packed Red Blood Cells
Drug: Albumin solutions
Drug: Plasma-Lyte
Drug: Lidocaine
Drug: Bupivacaine
Drug: Levobupivacaine
Drug: Ropivacaine
Drug: Mepivacaine
Drug: Tetracaine
Drug: Prilocaine
Drug: Procaine
Drug: Chloroprocaine
Drug: Benzocaine
Drug: Articaine

First Posted Date: 2016-04-04

Last Posted Date: 2019-05-16

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 22435

Registration Number: NCT02726620

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Anesthetic Efficacy of 1,8mL and 3,6mL of Articaine in Inferior Alveolar Nerve Block in Irreversible Pulpitis

Not Applicable

Completed

Conditions: Pulpitis

Interventions: Drug: Articaine
Drug: Epinephrine

First Posted Date: 2015-04-21

Last Posted Date: 2016-06-16

Lead Sponsor: Isabel Peixoto Tortamano

Target Recruit Count: 90

Registration Number: NCT02422823

Locations: 🇧🇷
Faculdade de Odontologia da USP, Sao Paulo, SP, Brazil

Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis

Phase 4

Completed

Conditions: Anesthesia of Mucous Membrane

Interventions: Drug: Benzocaine
Drug: Pliaglis
Drug: Articaine

First Posted Date: 2013-09-27

Last Posted Date: 2016-07-22

Lead Sponsor: University of Michigan

Target Recruit Count: 64

Registration Number: NCT01951820

Locations: 🇺🇸
University of Michigan Dental School, Ann Arbor, Michigan, United States

Drug Development Updates

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