Milrinone

Generic Name
Milrinone
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C12H9N3O
CAS Number
78415-72-2
Unique Ingredient Identifier
JU9YAX04C7
Background

Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. Often the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and metabolites, resulting in complex systemic pathologies. Heart ...

Indication

Milrinone is indicated for the short-term (48 hours or less) treatment of patients with acute decompensated heart failure. Milrinone administration should occur together with close monitoring using appropriate electrocardiographic equipment and should occur in a facility equipped for the immediate treatment of potential cardiac events, including ventricular ...

Associated Conditions
Acute Decompensated Heart Failure (ADHF), Congestive Heart Failure (CHF)
Associated Therapies
-
Clinical Trials
Related News

Decision Support for Intraoperative Low Blood Pressure

Not Applicable
Completed
Conditions
Hypotension
Interventions
Procedure: Attending real-time decision support
Procedure: In-room real-time decision support
Procedure: Attending feedback emails
Procedure: In-room provider feedback emails
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Device: Pager system
Procedure: Central neuraxial anesthesia
Procedure: Non-cardiac surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Desflurane
Drug: Isoflurane
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
Drug: Epinephrine
Drug: Dobutamine
Drug: Dopamine
Drug: Isoproterenol
Drug: Milrinone
Drug: Atropine
Drug: Glycopyrrolate
Drug: Vasopressin
Drug: Terlipressin
Drug: Sodium Chloride 0.9%
Drug: Ringer's lactate
Drug: Hydroxyethyl starch solutions
Drug: Fresh Frozen Plasma
Drug: Packed Red Blood Cells
Drug: Albumin solutions
Drug: Plasma-Lyte
Drug: Lidocaine
Drug: Bupivacaine
Drug: Levobupivacaine
Drug: Ropivacaine
Drug: Mepivacaine
Drug: Tetracaine
Drug: Prilocaine
Drug: Procaine
Drug: Chloroprocaine
Drug: Benzocaine
Drug: Articaine
First Posted Date
2016-04-04
Last Posted Date
2019-05-16
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
22435
Registration Number
NCT02726620
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Milrinone in Addition to Hyperdynamic Therapy in the Treatment of Vasospasm Following Aneurysmal Subarachnoid Hemorrhage

Phase 2
Terminated
Conditions
Cerebral Vasospasm
Interventions
Drug: Placebo
Drug: Milrinone
First Posted Date
2016-03-18
Last Posted Date
2019-07-02
Lead Sponsor
Indiana University
Target Recruit Count
4
Registration Number
NCT02712788
Locations
🇺🇸

Indiana University Heath Methodist Hospital, Indianapolis, Indiana, United States

Dobutamaine Versus Milrinone in Cardiorenal Syndrome

Phase 2
Withdrawn
Conditions
Cardiorenal Syndrome
Interventions
Drug: Milrinone
Drug: Dobutamine
First Posted Date
2015-12-31
Last Posted Date
2018-08-10
Lead Sponsor
Maimonides Medical Center
Registration Number
NCT02644057
Locations
🇺🇸

Maimonides Medical Center, Brooklyn, New York, United States

Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock

First Posted Date
2015-12-29
Last Posted Date
2018-11-29
Lead Sponsor
Sahlgrenska University Hospital, Sweden
Target Recruit Count
30
Registration Number
NCT02640846
Locations
🇸🇪

Central intensivvårdsavdelning Sahlgrenska University Hospital, Gothenburg, Västra Götaland, Sweden

Oral Sildenafil and Intravenous Milrinone on Postoperative Pulmonary Hypertension

Phase 1
Completed
Conditions
Pulmonary Hypertension
Interventions
Drug: milrinone
Drug: Sildenafil
First Posted Date
2015-11-03
Last Posted Date
2015-11-13
Lead Sponsor
Assiut University
Target Recruit Count
30
Registration Number
NCT02595541

Impact of CArdiopulmonary Bypass Flow on Renal Blood Flow, Function and OXygenation

First Posted Date
2015-09-14
Last Posted Date
2017-10-05
Lead Sponsor
Sahlgrenska University Hospital, Sweden
Target Recruit Count
18
Registration Number
NCT02549066
Locations
🇸🇪

Department of thoracic anesthesia, Sahlgrenska University Hospital, Gothenburg, Sweden

Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support.

First Posted Date
2015-04-03
Last Posted Date
2017-05-09
Lead Sponsor
Sahlgrenska University Hospital, Sweden
Target Recruit Count
30
Registration Number
NCT02408003
Locations
🇸🇪

Thoraxoperation/TIVA, Sahlgrenska universitetssjukhuset, Göteborg, Sweden

Is Levosimendan Superior to Milrinone Regarding Acute Kidney Injury After Cardiac Surgery for Congenital Heart Disease?

Phase 2
Completed
Conditions
Congenital Heart Defects
Interventions
Drug: Milrinone
Drug: Levosimendan
First Posted Date
2014-09-05
Last Posted Date
2024-03-26
Lead Sponsor
Göteborg University
Target Recruit Count
72
Registration Number
NCT02232399
Locations
🇫🇮

Children´s Hospital, Helsinki University Central Hospital, Helsinki, Finland

🇸🇪

Queen Silvia Children´s Hospital, Göteborg, Västra Götaland, Sweden

Concomitant Milrinone and Esmolol Treatment in Patients With Acute Myocardial Infarction

First Posted Date
2014-03-28
Last Posted Date
2017-10-09
Lead Sponsor
Ming-He Huang
Registration Number
NCT02098629
Locations
🇨🇳

Yuebei People's Hospital, Shaoguan, Guangdong, China

Pilot Study of Slow Release Oral Milrinone in Patients With Advanced Heart Failure

Phase 1
Completed
Conditions
Heart Failure
Interventions
Drug: Milrinone
First Posted Date
2013-10-08
Last Posted Date
2019-01-11
Lead Sponsor
The Alfred
Target Recruit Count
26
Registration Number
NCT01956006
Locations
🇦🇺

Alfred Hospital, Melbourne, Victoria, Australia

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