Zopiclone

Generic Name
Zopiclone
Brand Names
Imovane
Drug Type
Small Molecule
Chemical Formula
C17H17ClN6O3
CAS Number
43200-80-2
Unique Ingredient Identifier
03A5ORL08Q
Background

Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate-like properties.

Indication

For the short-term treatment of insomnia.

Associated Conditions
Insomnia
Associated Therapies
-
Clinical Trials
Related News

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Reassessment of Premedication in Surgery

Phase 4
Completed
Conditions
Anxiety
Interventions
Drug: placebo
Drug: Alprazolam
Drug: Zopiclone
First Posted Date
2012-03-09
Last Posted Date
2013-09-25
Lead Sponsor
University Hospital, Angers
Target Recruit Count
455
Registration Number
NCT01549691
Locations
🇫🇷

Dept of Anesthesia, Hôpital Foch,, Suresnes, Ile de France, France

🇫🇷

Dept of Anesthesia, Hôpital Tenon, Paris, Ile de France, France

🇫🇷

Clinique St Leonard, Trélazé, Maine et Loire, France

and more 5 locations

Effect of Zopiclone on Compliance With Continuous Positive Airway Pressure in Obstructive Sleep Apnea

Phase 3
Completed
Conditions
Obstructive Sleep Apnea
Interventions
Drug: Placebo
Drug: Zopiclone
First Posted Date
2011-06-09
Last Posted Date
2015-07-17
Lead Sponsor
OSR Medical Inc.
Target Recruit Count
264
Registration Number
NCT01369576
Locations
🇨🇦

Cite de la Sante, Laval, Quebec, Canada

🇨🇦

Institut de medecine specialisee de Laval, Laval, Quebec, Canada

🇨🇦

Institut de Medecine du sommeil, Montreal, Quebec, Canada

and more 1 locations

A Study to Evaluate Next Day Effects of MK-4305 on Driving Performance (MK-4305-035 AM1)

First Posted Date
2011-03-10
Last Posted Date
2016-02-22
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
28
Registration Number
NCT01311882
Locations
🇳🇱

Merck Sharp & Dohme B.V., Haarlem, Netherlands

Driving Simulator Performance After Intake of Zopiclone Sleeping Pills

First Posted Date
2010-12-09
Last Posted Date
2013-12-13
Lead Sponsor
St. Olavs Hospital
Registration Number
NCT01257165

Driving Performance After Middle of the Night Administration of 3.5 mg Zolpidem Tartrate Sublingual Tablet

First Posted Date
2010-04-20
Last Posted Date
2012-02-14
Lead Sponsor
Transcept Pharmaceuticals
Target Recruit Count
40
Registration Number
NCT01106859
Locations
🇳🇱

Maastricht University, Maastricht, Netherlands

A Non-inferiority Study With Two Treatment Arms Eszopiclone 3 mg Versus Zopiclone 7.5 mg - for the Treatment of Insomnia

Phase 3
Completed
Conditions
INSOMNIA
Interventions
Drug: Eszopiclone
Drug: Zopiclone
First Posted Date
2010-04-08
Last Posted Date
2015-07-27
Lead Sponsor
Eurofarma Laboratorios S.A.
Target Recruit Count
263
Registration Number
NCT01100164
Locations
🇧🇷

CRDB - Clinical Research & Development Brazil, São Paulo, Brazil

Changes in Blood Gases, Disturbance of Breath During Sleep and Cardiovascular Co-morbidity in COPD Patients

First Posted Date
2009-04-27
Last Posted Date
2012-05-16
Lead Sponsor
LHL Helse
Target Recruit Count
150
Registration Number
NCT00888342
Locations
🇳🇴

Glittreklinikken, Oslo, Hakadal, Norway

A Study to Assess the Effect of Single and Multiple Doses Org 50081 and a Single Dose of Zopiclone on Next-day Driving Ability and Psychomotor Performance in Healthy Volunteers. (P05794) (COMPLETED)

First Posted Date
2008-11-26
Last Posted Date
2015-10-14
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
32
Registration Number
NCT00798395

Cognitive-Behavioural and Hypnotic Treatment of Chronic Primary Insomnia Among the Elderly

Phase 4
Completed
Conditions
Insomnia
First Posted Date
2006-02-23
Last Posted Date
2009-01-06
Lead Sponsor
University of Bergen
Registration Number
NCT00295386
Locations
🇳🇴

University of Bergen, Bergen, Norway

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