Clozapine

Generic Name: Clozapine

Brand Names: Clozaril, Fazaclo, Versacloz

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₁₉ClN_₄

CAS Number: 5786-21-0

Unique Ingredient Identifier: J60AR2IKIC

Background: Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine receptors results in fewer extrapyramida...

Indication: Clozapine is indicated for the treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatment. Because of the risks of severe neutropenia and of seizure associated with its use, Clozapine should be used only in patients who have failed to respond adequately to standard antipsychotic treatment.
...

Associated Conditions: Suicidal Behaviour, Treatment Resistant Schizophrenia, Advanced dopaminomimetic psychosis

Associated Therapies: -

Clinical Trials

Family Intervention in Recent Onset Schizophrenia Treatment (FIRST)

First Posted Date: 2015-11-09

Last Posted Date: 2019-01-23

Lead Sponsor: Janssen Scientific Affairs, LLC

Target Recruit Count: 296

Registration Number: NCT02600741

Clozapine Versus Other Atypical Antipsychotics for Bipolar Disorder

Phase 4

Conditions: Bipolar Disorder

Interventions: Drug: Clozapine
Drug: Risperidone
Drug: Olanzapine
Drug: Quetiapine

First Posted Date: 2015-09-29

Last Posted Date: 2018-10-02

Lead Sponsor: Hospital de Clinicas de Porto Alegre

Target Recruit Count: 54

Registration Number: NCT02562287

Locations: 🇧🇷
Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul, Brazil

Biomarker and Safety Study of Clozapine in Patients With Benign Ethnic Neutropenia (BEN)

Not Applicable

Completed

Conditions: Schizophrenia

Interventions: Drug: Clozapine

First Posted Date: 2015-03-31

Last Posted Date: 2023-01-31

Lead Sponsor: University of Maryland, Baltimore

Target Recruit Count: 274

Registration Number: NCT02404155

Locations: 🇺🇸
Maryland Psychiatric Research Center, Catonsville, Maryland, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3

Terminated

Conditions: Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders

Interventions: Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium

First Posted Date: 2015-03-02

Last Posted Date: 2018-02-28

Lead Sponsor: Hannover Medical School

Target Recruit Count: 407

Registration Number: NCT02374567

Locations: 🇩🇪
Bezirkskrankenhaus Augsburg, Augsburg, Germany
🇩🇪
Krankenhaus Hedwigshöhe, Berlin, Germany
🇩🇪
Hannover Medical School, Hannover, Germany

and more 2 locations

Study of the Effect of Dosing on Clozapine Levels

Phase 4

Withdrawn

Conditions: Psychotic Disorders
Schizophrenia

Interventions: Drug: Clozapine

First Posted Date: 2014-11-07

Last Posted Date: 2021-10-08

Lead Sponsor: University of British Columbia

Registration Number: NCT02286206

Locations: 🇨🇦
UBC Hospital - Detwiller Pavilion, Vancouver, British Columbia, Canada

Clozapine Plasma Levels and the Relationship to the Genetic Polymorphism in Shizophrenic Patients

Phase 4

Completed

Conditions: Schizophrenia

Interventions: Drug: Clozapine

First Posted Date: 2012-08-13

Last Posted Date: 2017-10-12

Lead Sponsor: Tirat Carmel Mental Health Center

Target Recruit Count: 20

Registration Number: NCT01663077

Locations: 🇮🇱
Tirat Carmel Mental Health Center, Tirat Carmel, Israel

A Study to Compare the Pharmacokinetics Profile of DWCZP Tablet 100mg and Clozaril® Tablet 100mg

Phase 1

Completed

Conditions: Schizophrenia

Interventions: Drug: DWCZP
Drug: Clozaril

First Posted Date: 2012-08-01

Last Posted Date: 2017-03-27

Lead Sponsor: Dong Wha Pharmaceutical Co. Ltd.

Target Recruit Count: 28

Registration Number: NCT01654601

Locations: 🇰🇷
The Catholic University of Korea, yeouido St.Mary's Hospital, Seoul, Korea, Republic of
🇰🇷
Seoul National Hospital, Seoul, Korea, Republic of
🇰🇷
Naju National Hospital, Naju, Korea, Republic of

and more 2 locations

Clozapine for Cannabis Use in Schizophrenia

Phase 4

Completed

Conditions: Schizophrenia
Dual Diagnosis
Cannabis Abuse
Cannabis Dependence

Interventions: Drug: Clozapine
Drug: Risperidone

First Posted Date: 2012-07-13

Last Posted Date: 2020-05-05

Lead Sponsor: Dartmouth-Hitchcock Medical Center

Target Recruit Count: 49

Registration Number: NCT01639872

Locations: 🇺🇸
Pacific Research Partners, Oakland, California, United States
🇺🇸
University of North Carolina/UNC Center for Excellence in Community Mental Health, Raleigh, North Carolina, United States
🇺🇸
CNS Network Inc, Garden Grove, California, United States

and more 6 locations

An Observational Drug Utilization Study of Asenapine in the United Kingdom (P08308)

Completed

Conditions: Bipolar Disorder

Interventions: Drug: Risperidone
Drug: Iloperidone
Drug: Clozapine
Drug: Sertindole
Drug: Asenapine
Drug: Aripiprazole
Drug: Quetiapine
Drug: Olanzapine
Drug: Ziprasidone
Drug: Paliperidone
Drug: Lurasidone
Drug: Amisulpride
Drug: Zotepine

First Posted Date: 2011-12-23

Last Posted Date: 2022-02-04

Lead Sponsor: Organon and Co

Target Recruit Count: 42

Registration Number: NCT01498770

Clozapine Versus Amisulpride in Treatment-resistant Schizophrenia Patients

Not Applicable

Withdrawn

Conditions: Schizophrenia
Treatment Resistant Disorders

Interventions: Drug: Clozapine
Drug: Amisulpride
Drug: Clozapine+Amisulpride

First Posted Date: 2011-10-07

Last Posted Date: 2015-12-09

Lead Sponsor: Geha Mental Health Center

Registration Number: NCT01448499

Locations: 🇮🇱
Geha Mental Health Center, Petach-Tikva, Israel

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