Duloxetine
- Generic Name
- Duloxetine
- Brand Names
- Cymbalta, Drizalma, Irenka, Yentreve, Duloxetine Zentiva, Duloxetine Mylan, Duloxetine Lilly
- Drug Type
- Small Molecule
- Chemical Formula
- C18H19NOS
- CAS Number
- 116539-59-4
- Unique Ingredient Identifier
- O5TNM5N07U
- Background
Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor. It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval for a variety of indications including the tre...
- Indication
Indicated for:
1) Management of Major Depressive Disorder.
2) Management of Generalized Anxiety Disorder.
3) Management of diabetic peripheral neuropathy.
4) Management of fibromyalgia.
5) Management of chronic musculoskeletal pain.
6) Management of osteoarthritis of the knee in adults.
7) Management of chronic lower back pain in adults.
...
- Associated Conditions
- Chronic Lower Back Pain (CLBP), Chronic Musculoskeletal Pain, Diabetic Peripheral Neuropathic Pain (DPN), Fibromyalgia, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Osteoarthritis of the Knee, Stress Urinary Incontinence (SUI)
- Associated Therapies
- -
Analgesic Efficacy of Duloxetine in Patients Undergoing Lumbar Discectomy
- First Posted Date
- 2018-06-07
- Last Posted Date
- 2019-07-08
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 70
- Registration Number
- NCT03549026
- Locations
- 🇪🇬
Diab, Assiut, Assuit, Egypt
Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care Randomization
- First Posted Date
- 2018-06-07
- Last Posted Date
- 2024-11-22
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 320
- Registration Number
- NCT03548454
- Locations
- 🇺🇸
Stanford Pain Management Center, Redwood City, California, United States
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
- Conditions
- Interventions
- Drug: Tranexamic acid (TXA)Drug: HydrocodoneDrug: labetalolDrug: metforminDrug: nifedipineDrug: oxycodoneDrug: clindamycinDrug: azithromycinDrug: escitalopramDrug: sertralineDrug: CiprofloxacinDrug: ondansetronDrug: DoxycyclineDrug: LevofloxacinDrug: MethylphenidateDrug: CitalopramDrug: SumatriptanDrug: CyclobenzaprineDrug: FurosemideDrug: RosuvastatinDrug: GabapentinDrug: HydrochlorothiazideDrug: HydroxyureaDrug: TrazodoneDrug: TopiramateDrug: ValganciclovirDrug: RemdesivirDrug: VenlafaxineDrug: VerapamilDrug: FluvoxamineDrug: AnakinraDrug: TocilizumabDrug: AmoxicillinDrug: BupropionDrug: BuprenorphineDrug: LevetiracetamDrug: ParoxetineDrug: Duloxetine
- First Posted Date
- 2018-04-27
- Last Posted Date
- 2024-12-17
- Lead Sponsor
- Duke University
- Target Recruit Count
- 1600
- Registration Number
- NCT03511118
- Locations
- 🇺🇸
Northwestern University, Chicago, Illinois, United States
🇺🇸Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, Illinois, United States
🇺🇸Loma Linda University Health, Loma Linda, California, United States
Comparative Efficacy of Duloxetine vs Escitalopram in Patients With Fibromyalgia
- First Posted Date
- 2018-04-03
- Last Posted Date
- 2020-02-27
- Lead Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
- Target Recruit Count
- 200
- Registration Number
- NCT03487211
- Locations
- 🇵🇰
Pakistan Institute of Medical Sciences, Islamabad, Islamabad Capital Territory, Pakistan
Duloxetine for Acute Post-mastectomy Pain
- First Posted Date
- 2018-03-16
- Last Posted Date
- 2020-06-24
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 88
- Registration Number
- NCT03468348
- Locations
- 🇪🇬
Diab, Assiut, Assuit, Egypt
Genetic Variants Associated With Low Back Pain and Their Response to Treatment With Duloxetine or Propranolol
- Conditions
- Interventions
- First Posted Date
- 2017-12-06
- Last Posted Date
- 2018-08-28
- Lead Sponsor
- Mark Ware
- Target Recruit Count
- 10
- Registration Number
- NCT03364075
- Locations
- 🇨🇦
Centre for Innovative Medicine - McGill University Health Centre, Montréal, Quebec, Canada
Perioperative Duloxetine for Pain Management After Laparoscopic Hysterectomy
- Conditions
- Interventions
- First Posted Date
- 2017-11-22
- Last Posted Date
- 2018-05-16
- Lead Sponsor
- Acibadem University
- Target Recruit Count
- 100
- Registration Number
- NCT03350334
- Locations
- 🇹🇷
Acibadem Maslak Hospital, Sariyer, Istanbul, Turkey
Towards Neurobiology-based Diagnosis and Treatment of Affective Disorders
- First Posted Date
- 2017-09-27
- Last Posted Date
- 2021-08-30
- Lead Sponsor
- Peking University
- Target Recruit Count
- 400
- Registration Number
- NCT03294525
- Locations
- 🇨🇳
Institute of mental health, Peking University, Beijing, Beijing, China
'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug
- Conditions
- Interventions
- First Posted Date
- 2017-09-08
- Last Posted Date
- 2021-05-20
- Lead Sponsor
- Rambam Health Care Campus
- Target Recruit Count
- 300
- Registration Number
- NCT03276689
- Locations
- 🇮🇱
Rambam Medical Center, Haifa, Israel
Effect of Combined Morphine and Duloxetine on Chronic Pain
- Conditions
- Interventions
- First Posted Date
- 2017-08-15
- Last Posted Date
- 2024-11-14
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 81
- Registration Number
- NCT03249558
- Locations
- 🇺🇸
Karina de Sousa, Boston, Massachusetts, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.