Topiramate

Generic Name: Topiramate

Brand Names: Eprontia, Qsymia, Qudexy, Topamax, Trokendi

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₂₁NO_₈S

CAS Number: 97240-79-4

Unique Ingredient Identifier: 0H73WJJ391

Background: Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy in adults.
...

Indication: Topiramate is indicated for the following conditions: 1)Monotherapy for partial onset or primary generalized tonic-clonic seizures for patients 2 years of age and above 2)Adjunctive therapy for partial onset seizures or primary generalized tonic-clonic seizures for both adult and pediatric patients above 2 years old 3)Adjunctive therapy for seizures associat...

Associated Conditions: Alcohol Dependency, Epilepsy, Primary Generalized Tonic-Clonic Seizures, Generalized Tonic-Clonic Seizures, Lennox-Gastaut Syndrome, Migraine, Moods Disorders, Partial-Onset Seizures, Seizures, Weight

Associated Therapies: Chronic Weight Management therapy, Weight Reduction

Clinical Trials

Efficacy and Safety of Danzhen

Phase 1

Conditions: Migraine

Interventions: Drug: Danzhen
Drug: Topiramate

First Posted Date: 2016-01-01

Last Posted Date: 2016-01-01

Lead Sponsor: Xijing Hospital

Target Recruit Count: 3300

Registration Number: NCT02645370

Locations: 🇨🇳
Xijing Hospital, Xi'an, Shanxi, China

Migraine Treatment in ED

Not Applicable

Withdrawn

Conditions: Migraine

Interventions: Drug: Topiramate
Behavioral: Relaxation Therapy
Drug: Standard of Care
Drug: Abortive Medication (Naproxen and Sumatriptan)

First Posted Date: 2015-12-31

Last Posted Date: 2018-08-24

Lead Sponsor: NYU Langone Health

Registration Number: NCT02643719

Flunarizine Versus Topiramate for Chronic Migraine Prophylaxis

Phase 4

Completed

Conditions: Chronic Migraine

Interventions: Drug: Flunarizine
Drug: Topiramate

First Posted Date: 2015-12-24

Last Posted Date: 2015-12-24

Lead Sponsor: Taipei Veterans General Hospital, Taiwan

Target Recruit Count: 62

Registration Number: NCT02639598

Topiramate and Cerebrovascular Response in Migraineurs

Phase 4

Completed

Conditions: Migraine Disorders

Interventions: Drug: Topiramate

First Posted Date: 2015-04-23

Last Posted Date: 2015-04-23

Lead Sponsor: SMG-SNU Boramae Medical Center

Target Recruit Count: 19

Registration Number: NCT02424318

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3

Terminated

Conditions: Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders

Interventions: Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium

First Posted Date: 2015-03-02

Last Posted Date: 2018-02-28

Lead Sponsor: Hannover Medical School

Target Recruit Count: 407

Registration Number: NCT02374567

Locations: 🇩🇪
Bezirkskrankenhaus Augsburg, Augsburg, Germany
🇩🇪
Krankenhaus Hedwigshöhe, Berlin, Germany
🇩🇪
Hannover Medical School, Hannover, Germany

and more 2 locations

A Randomized, Double-blind Placebo-Controlled Pharmacogenetic Study of Topiramate in European-American Heavy Drinkers

Phase 2

Completed

Conditions: Alcohol Use Disorder (AUD)
Alcoholism

Interventions: Behavioral: Medical Management
Drug: Topiramate
Drug: Inactive Placebo

First Posted Date: 2015-02-26

Last Posted Date: 2022-01-20

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 320

Registration Number: NCT02371889

Locations: 🇺🇸
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, United States
🇺🇸
University of Pennsylvania Treatment Research Center, Philadelphia, Pennsylvania, United States

A Open-label, Drug Interaction Study Between Eslicarbazepine Acetate and Topiramate

Phase 1

Completed

Conditions: Epilepsy

Interventions: Drug: BIA 2-093
Drug: Topamax

First Posted Date: 2014-11-05

Last Posted Date: 2014-12-22

Lead Sponsor: Bial - Portela C S.A.

Target Recruit Count: 32

Registration Number: NCT02283814

Topiramate and Severe Obesity

Phase 3

Completed

Conditions: Obese Children and Adolescents

Interventions: Drug: Placebo
Drug: Topiramate

First Posted Date: 2014-10-24

Last Posted Date: 2019-02-19

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 18

Registration Number: NCT02273804

Locations: 🇫🇷
Hopital Bicêtre, Le Kremlin-Bicêtre, Paris, France

Topiramate-Phentermine Combinations for Cocaine Dependence

Phase 1

Completed

Conditions: Cocaine Use Disorder

Interventions: Drug: Cocaine
Drug: Placebo
Drug: Phentermine
Drug: Topiramate

First Posted Date: 2014-09-15

Last Posted Date: 2019-11-27

Lead Sponsor: University of Kentucky

Target Recruit Count: 38

Registration Number: NCT02239913

Locations: 🇺🇸
University of Kentucky Medical Center, Lexington, Kentucky, United States

Effect of VI-0521 (Qsymia®) on Glomerular Filtration Rate (GFR) in Overweight or Obese Healthy Subjects

Phase 4

Completed

Conditions: Obesity

Interventions: Drug: Placebo
Drug: Qsymia

First Posted Date: 2014-09-01

Last Posted Date: 2017-11-07

Lead Sponsor: VIVUS LLC

Target Recruit Count: 51

Registration Number: NCT02229214

Locations: 🇺🇸
Research Center, Lakewood, Colorado, United States

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