Benzocaine
- Generic Name
- Benzocaine
- Brand Names
- Anbesol Cold Sore Therapy, Cepacol Sore Throat Plus Cough, Cetacaine, Chloraseptic Sore Throat, Chloraseptic Sore Throat + Cough, Diphen, Docusol Plus, Enemeez Plus, Medicaine Sting and Bite, One Touch Reformulated Apr 2009, Orasep Reformulated Dec 2013, Rectogel, Salinocaine, Topex, Vagisil Original Formula, Zap, Zilactin-B
- Drug Type
- Small Molecule
- Chemical Formula
- C9H11NO2
- CAS Number
- 94-09-7
- Unique Ingredient Identifier
- U3RSY48JW5
- Background
Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. It is commonly used for local anesthesia in many over the counter products. Benzocaine was first used for local anesthesia in dentistry.
- Indication
Benzocaine is indicated for local anesthesia in dentistry, minor trauma, and as preparation for infiltrative anesthesia. Benzocaine products are indicated for topical anesthesia in a wide variety of conditions including skin irritation, oral pain, and hemorrhoids.
- Associated Conditions
- Acute Sore Throat Pain, Dental Pain, Gangrene Stomatitis, Gingivitis, Haemorrhoids, Laryngitis, Pharyngitis, Premature Ejaculation, Secondary Bacterial Infection caused by Tonsillectomy, Secondary Bacterial Infection caused by Tooth Extractions, Skin Irritation, Sore Throat, Stomatitis, Sunburn, Teething pain, Tonsillitis, Tooth Pain, Vomiting, Pruritic dermatosis, Ulceration of the mouth
- Associated Therapies
- Buccopharyngeal anesthesia
Decision Support for Intraoperative Low Blood Pressure
- Conditions
- Hypotension
- Interventions
- Procedure: Attending real-time decision supportProcedure: In-room real-time decision supportProcedure: Attending feedback emailsProcedure: In-room provider feedback emailsDevice: Anesthesia Information Management System (AIMS)Device: Perioperative Data Warehouse (PDW)Procedure: General anesthesiaDevice: Pager systemProcedure: Central neuraxial anesthesiaProcedure: Non-cardiac surgeryDrug: Ringer's lactateDrug: Hydroxyethyl starch solutionsDrug: Packed Red Blood CellsDrug: Albumin solutions
- First Posted Date
- 2016-04-04
- Last Posted Date
- 2019-05-16
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 22435
- Registration Number
- NCT02726620
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans
- First Posted Date
- 2015-09-01
- Last Posted Date
- 2022-12-09
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 27
- Registration Number
- NCT02537314
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Study to Assess the Safety and Efficacy of Benzocaine for Pain Relief in Children Presenting With Acute Otitis Media
- First Posted Date
- 2014-03-20
- Last Posted Date
- 2015-05-25
- Lead Sponsor
- Otic Therapy, LLC
- Target Recruit Count
- 65
- Registration Number
- NCT02092454
Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007)
- First Posted Date
- 2014-02-28
- Last Posted Date
- 2017-01-24
- Lead Sponsor
- Arbor Pharmaceuticals, Inc.
- Target Recruit Count
- 178
- Registration Number
- NCT02074007
- Locations
- 🇺🇸
Valley Stream Pediatrics, Valley Stream, New York, United States
🇺🇸Omaha ENT Clinic, Omaha, Nebraska, United States
🇺🇸Sterling Research Group, LTD, Cinncinati, Ohio, United States
Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media
- First Posted Date
- 2014-01-24
- Last Posted Date
- 2015-04-08
- Lead Sponsor
- Arbor Pharmaceuticals, Inc.
- Target Recruit Count
- 304
- Registration Number
- NCT02044341
- Locations
- 🇺🇸
PMG Research of Bristol, Bristol, Tennessee, United States
🇺🇸The Iowa Clinic, Pc, West Des Moines, Iowa, United States
🇺🇸Clinical Research Center, Las Vegas, Nevada, United States
Four Arm Safety & Efficacy With Antipyrine and Benzocaine Otic Solution in Children With Acute Otitis Media
- Conditions
- Acute Otitis Media
- Interventions
- Drug: Placebo Otic solution
- First Posted Date
- 2014-01-16
- Last Posted Date
- 2024-08-07
- Lead Sponsor
- Currax Pharmaceuticals
- Target Recruit Count
- 112
- Registration Number
- NCT02037893
- Locations
- 🇺🇸
FirstMed East, Salt Lake City, Utah, United States
🇺🇸Desert Clinical Research, Mesa, Arizona, United States
🇺🇸Visions Clinical Research, Boynton Beach, Florida, United States
Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis
- Conditions
- Anesthesia of Mucous Membrane
- Interventions
- First Posted Date
- 2013-09-27
- Last Posted Date
- 2016-07-22
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 64
- Registration Number
- NCT01951820
- Locations
- 🇺🇸
University of Michigan Dental School, Ann Arbor, Michigan, United States
Benzocaine Versus Placebo Spray for Pain Relief at Hysterosalpingogram
- First Posted Date
- 2013-08-19
- Last Posted Date
- 2017-04-28
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 30
- Registration Number
- NCT01925469
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
EMLA Topical Anesthetic During Scaling and Root Planing
- Conditions
- Local AnesthesiaPain, PostoperativeSelf-Perception
- Interventions
- First Posted Date
- 2013-05-22
- Last Posted Date
- 2013-05-22
- Lead Sponsor
- Franciscan University Center
- Target Recruit Count
- 32
- Registration Number
- NCT01860235
Nutrient Sensing in the Duodenum
- Conditions
- The Effect of LCFA on Nutrient Absorption
- Interventions
- First Posted Date
- 2012-09-26
- Last Posted Date
- 2024-04-11
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 16
- Registration Number
- NCT01694004
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.