Clomipramine

Generic Name
Clomipramine
Brand Names
Anafranil
Drug Type
Small Molecule
Chemical Formula
C19H23ClN2
CAS Number
303-49-1
Unique Ingredient Identifier
NUV44L116D
Background

Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depress...

Indication

May be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette’s disorder).
...

Associated Conditions
Depression, Obsessive Compulsive Disorder (OCD), Panic Disorder
Associated Therapies
-
Clinical Trials
Related News

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Interpersonal Psychotherapy for Treatment Resistant Depression

First Posted Date
2013-07-11
Last Posted Date
2013-07-11
Lead Sponsor
Hospital de Clinicas de Porto Alegre
Target Recruit Count
74
Registration Number
NCT01896349
Locations
🇧🇷

Federal University of Rio Grande do Sul / Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil

Citalopram vs Clomipramine vs Placebo in Recurrent Depression

Not Applicable
Completed
Conditions
Depression
Interventions
Drug: Citalopram
Drug: Clomipramine
Drug: placebo
First Posted Date
2012-04-11
Last Posted Date
2012-04-11
Lead Sponsor
University of Aarhus
Target Recruit Count
59
Registration Number
NCT01575158

Trial of PED-1 in Male Patients With Premature Ejaculation

Phase 3
Completed
Conditions
Premature Ejaculation
Interventions
Drug: Clomipramine
First Posted Date
2011-09-23
Last Posted Date
2012-10-03
Lead Sponsor
Symyoo
Target Recruit Count
159
Registration Number
NCT01439984
Locations
🇰🇷

Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do, Korea, Republic of

🇰🇷

National Health Insurance Corporation Ilsan Hospital, Goyang-si, Gyeonggi-do, Korea, Republic of

🇰🇷

Uijeongbu St.Marry's Hospital, Uijeongbu-si, Gyeonggi-do, Korea, Republic of

and more 2 locations

Predicting Medication Response in Obsessive Compulsive Disorder

First Posted Date
2011-07-28
Last Posted Date
2013-01-31
Lead Sponsor
Sunnybrook Health Sciences Centre
Target Recruit Count
26
Registration Number
NCT01404871
Locations
🇨🇦

Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

🇨🇦

The Centre for Addiction and Mental Health, Toronto, Ontario, Canada

Phase 2 Trial of PED-1 and PED-2 in Male Patients With Premature Ejaculation

Phase 2
Completed
Conditions
Premature Ejaculation
Interventions
Drug: Clomipramine
First Posted Date
2010-09-16
Last Posted Date
2012-10-03
Lead Sponsor
Symyoo
Target Recruit Count
104
Registration Number
NCT01203202
Locations
🇰🇷

Ewha University Mok-dong Hospital, Seoul, Korea, Republic of

🇰🇷

Seoul St. Marry's Hospital, Seoul, Korea, Republic of

Quetiapine Augmentation Versus Clomipramine Augmentation of SSRI for Obsessive-compulsive Disorder Patients

First Posted Date
2007-11-28
Last Posted Date
2017-10-27
Lead Sponsor
University of Sao Paulo
Target Recruit Count
21
Registration Number
NCT00564564
Locations
🇧🇷

Institute of Psychiatry, Clinics Hospital, University of São Paulo Medical School, São Paulo, SP, Brazil

Phase II Randomized Study of Intravenous Versus Oral Clomipramine in Patients With Obsessive Compulsive Disorder

First Posted Date
1999-10-19
Last Posted Date
2005-06-24
Lead Sponsor
National Center for Research Resources (NCRR)
Target Recruit Count
76
Registration Number
NCT00004310
Locations
🇺🇸

Stanford University Medical Center, Stanford, California, United States

🇺🇸

University of Cincinnati Medical Center, Cincinnati, Ohio, United States

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