Bupivacaine

Generic Name
Bupivacaine
Brand Names
Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
Drug Type
Small Molecule
Chemical Formula
C18H28N2O
CAS Number
38396-39-3
Unique Ingredient Identifier
Y8335394RO
Background

Bupivacaine is a widely used local anesthetic agent.

Indication

As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions
Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
Associated Therapies
General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Clinical Trials
Related News

Wound Infiltration With Sodium Diclofenac vs Bupivacaine for Postoperative Pain Following Appendectomy

Phase 3
Completed
Conditions
Postoperative Pain
Interventions
Drug: Bupivacaine
Drug: Sodium diclofenac
First Posted Date
2016-04-27
Last Posted Date
2016-04-27
Lead Sponsor
Hospital Central Dr. Luis Ortega
Target Recruit Count
43
Registration Number
NCT02752971

Effectiveness of Caudal Epidural Block on Intraoperative Blood Loss During Hypospadias Repair

First Posted Date
2016-04-26
Last Posted Date
2016-04-26
Lead Sponsor
Isfahan University of Medical Sciences
Target Recruit Count
60
Registration Number
NCT02752308

Wound Infiltration With Liposomal Bupivacaine vs. Standard Wound Infiltration With Bupivacaine in Patient's Undergoing Open Gynecologic Surgery on an Enhanced Recovery Pathway

First Posted Date
2016-04-15
Last Posted Date
2021-10-18
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
105
Registration Number
NCT02740114
Locations
🇺🇸

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Comparing Pain Relief Between Exparel® Injection vs. On-Q Catheter as the Postsurgical Analgesia Following Total Knee Arthroplasty (TKA)

First Posted Date
2016-04-15
Last Posted Date
2016-04-15
Lead Sponsor
Rothman Institute Orthopaedics
Registration Number
NCT02739230

Pain Control After Total Knee Arthroplasty: Benefit In Adding Single Shot Adductor Canal Block to Existing Pain Regimen Protocol?

First Posted Date
2016-04-15
Last Posted Date
2023-10-30
Lead Sponsor
Henry Ford Health System
Target Recruit Count
128
Registration Number
NCT02740192
Locations
🇺🇸

Henry Ford Hospital, Detroit, Michigan, United States

Decision Support for Intraoperative Low Blood Pressure

Not Applicable
Completed
Conditions
Hypotension
Interventions
Procedure: Attending real-time decision support
Procedure: In-room real-time decision support
Procedure: Attending feedback emails
Procedure: In-room provider feedback emails
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Device: Pager system
Procedure: Central neuraxial anesthesia
Procedure: Non-cardiac surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Desflurane
Drug: Isoflurane
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
Drug: Epinephrine
Drug: Dobutamine
Drug: Dopamine
Drug: Isoproterenol
Drug: Milrinone
Drug: Atropine
Drug: Glycopyrrolate
Drug: Vasopressin
Drug: Terlipressin
Drug: Sodium Chloride 0.9%
Drug: Ringer's lactate
Drug: Hydroxyethyl starch solutions
Drug: Fresh Frozen Plasma
Drug: Packed Red Blood Cells
Drug: Albumin solutions
Drug: Plasma-Lyte
Drug: Lidocaine
Drug: Bupivacaine
Drug: Levobupivacaine
Drug: Ropivacaine
Drug: Mepivacaine
Drug: Tetracaine
Drug: Prilocaine
Drug: Procaine
Drug: Chloroprocaine
Drug: Benzocaine
Drug: Articaine
First Posted Date
2016-04-04
Last Posted Date
2019-05-16
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
22435
Registration Number
NCT02726620
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Tizanidine and Superficial Cervical Block on Pain After Thyroidectomy

First Posted Date
2016-04-01
Last Posted Date
2016-12-20
Lead Sponsor
Ataturk University
Target Recruit Count
60
Registration Number
NCT02725359
Locations
🇹🇷

Ataturk University, Yakutiye, Erzurum, Turkey

Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty

Phase 4
Completed
Conditions
Pain
Interventions
Drug: EXPAREL
Drug: Bupivacaine
First Posted Date
2016-03-18
Last Posted Date
2020-12-11
Lead Sponsor
Pacira Pharmaceuticals, Inc
Target Recruit Count
140
Registration Number
NCT02713490
Locations
🇺🇸

Holy Cross Hospital, Fort Lauderdale, Florida, United States

🇺🇸

Loma Linda University, Loma Linda, California, United States

🇺🇸

Institute for Joint Restoration, Fremont, California, United States

and more 14 locations

Oblique Subcostal Tap Block Efficacy in Laparoscopic Cholecystectomy

First Posted Date
2016-03-14
Last Posted Date
2016-03-14
Lead Sponsor
Iuliu Hatieganu University of Medicine and Pharmacy
Target Recruit Count
120
Registration Number
NCT02707250
Locations
🇷🇴

Regional Institute of Gastroenterology and Hepatology "Prof.dr.Octavian Fodor", Cluj-Napoca, Cluj, Romania

Immune Response of Caudally Administrated Tramadol In Pediatric Lower Abdominal Surgery

Phase 2
Completed
Conditions
Acute Pain
Interventions
Drug: Bupivacaine
Drug: Tramadol
First Posted Date
2016-03-09
Last Posted Date
2017-10-19
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT02703415
Locations
🇪🇬

Faculty of Medicine, Assiut, Egypt

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