Clozapine

Generic Name
Clozapine
Brand Names
Clozaril, Fazaclo, Versacloz
Drug Type
Small Molecule
Chemical Formula
C18H19ClN4
CAS Number
5786-21-0
Unique Ingredient Identifier
J60AR2IKIC
Background

Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine receptors results in fewer extrapyramida...

Indication

Clozapine is indicated for the treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatment. Because of the risks of severe neutropenia and of seizure associated with its use, Clozapine should be used only in patients who have failed to respond adequately to standard antipsychotic treatment.
...

Associated Conditions
Suicidal Behaviour, Treatment Resistant Schizophrenia, Advanced dopaminomimetic psychosis
Associated Therapies
-
Clinical Trials
Related News

Family Intervention in Recent Onset Schizophrenia Treatment (FIRST)

First Posted Date
2015-11-09
Last Posted Date
2019-01-23
Lead Sponsor
Janssen Scientific Affairs, LLC
Target Recruit Count
296
Registration Number
NCT02600741

Clozapine Versus Other Atypical Antipsychotics for Bipolar Disorder

First Posted Date
2015-09-29
Last Posted Date
2018-10-02
Lead Sponsor
Hospital de Clinicas de Porto Alegre
Target Recruit Count
54
Registration Number
NCT02562287
Locations
🇧🇷

Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul, Brazil

Biomarker and Safety Study of Clozapine in Patients With Benign Ethnic Neutropenia (BEN)

Not Applicable
Completed
Conditions
Schizophrenia
Interventions
Drug: Clozapine
First Posted Date
2015-03-31
Last Posted Date
2023-01-31
Lead Sponsor
University of Maryland, Baltimore
Target Recruit Count
274
Registration Number
NCT02404155
Locations
🇺🇸

Maryland Psychiatric Research Center, Catonsville, Maryland, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Study of the Effect of Dosing on Clozapine Levels

Phase 4
Withdrawn
Conditions
Psychotic Disorders
Schizophrenia
Interventions
Drug: Clozapine
First Posted Date
2014-11-07
Last Posted Date
2021-10-08
Lead Sponsor
University of British Columbia
Registration Number
NCT02286206
Locations
🇨🇦

UBC Hospital - Detwiller Pavilion, Vancouver, British Columbia, Canada

Clozapine Plasma Levels and the Relationship to the Genetic Polymorphism in Shizophrenic Patients

Phase 4
Completed
Conditions
Schizophrenia
Interventions
Drug: Clozapine
First Posted Date
2012-08-13
Last Posted Date
2017-10-12
Lead Sponsor
Tirat Carmel Mental Health Center
Target Recruit Count
20
Registration Number
NCT01663077
Locations
🇮🇱

Tirat Carmel Mental Health Center, Tirat Carmel, Israel

A Study to Compare the Pharmacokinetics Profile of DWCZP Tablet 100mg and Clozaril® Tablet 100mg

Phase 1
Completed
Conditions
Schizophrenia
Interventions
Drug: DWCZP
Drug: Clozaril
First Posted Date
2012-08-01
Last Posted Date
2017-03-27
Lead Sponsor
Dong Wha Pharmaceutical Co. Ltd.
Target Recruit Count
28
Registration Number
NCT01654601
Locations
🇰🇷

The Catholic University of Korea, yeouido St.Mary's Hospital, Seoul, Korea, Republic of

🇰🇷

Seoul National Hospital, Seoul, Korea, Republic of

🇰🇷

Naju National Hospital, Naju, Korea, Republic of

and more 2 locations

Clozapine for Cannabis Use in Schizophrenia

First Posted Date
2012-07-13
Last Posted Date
2020-05-05
Lead Sponsor
Dartmouth-Hitchcock Medical Center
Target Recruit Count
49
Registration Number
NCT01639872
Locations
🇺🇸

Pacific Research Partners, Oakland, California, United States

🇺🇸

University of North Carolina/UNC Center for Excellence in Community Mental Health, Raleigh, North Carolina, United States

🇺🇸

CNS Network Inc, Garden Grove, California, United States

and more 6 locations

An Observational Drug Utilization Study of Asenapine in the United Kingdom (P08308)

First Posted Date
2011-12-23
Last Posted Date
2022-02-04
Lead Sponsor
Organon and Co
Target Recruit Count
42
Registration Number
NCT01498770

Clozapine Versus Amisulpride in Treatment-resistant Schizophrenia Patients

First Posted Date
2011-10-07
Last Posted Date
2015-12-09
Lead Sponsor
Geha Mental Health Center
Registration Number
NCT01448499
Locations
🇮🇱

Geha Mental Health Center, Petach-Tikva, Israel

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