Lacosamide

Generic Name
Lacosamide
Brand Names
Motpoly, Vimpat, Lacosamide Adroiq, Lacosamide Accord, Lacosamide UCB
Drug Type
Small Molecule
Chemical Formula
C13H18N2O3
CAS Number
175481-36-4
Unique Ingredient Identifier
563KS2PQY5
Background

Lacosamide is a functionalized amino acid that has activity in the maximal electroshock seizure test, and is indicated for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Recent studies indicate that Lacosamide only affects those neurons which are depolarized or active for long periods of time, typical of neurons at the focu...

Indication

Lacosamide is indicated for the treatment of partial-onset seizures in patients aged one month and older and as adjunctive therapy in the treatment of primary generalized tonic-clonic seizures in patients aged four years and older.

Associated Conditions
Epilepsy, Primary Generalized Tonic-Clonic Seizures, Partial-Onset Seizures, Status Epilepticus
Associated Therapies
-

Lacosamide Effects on Alcohol Self Administration and Craving in Heavy Drinkers

First Posted Date
2017-09-05
Last Posted Date
2021-06-03
Lead Sponsor
Boston Medical Center
Target Recruit Count
66
Registration Number
NCT03271528
Locations
🇺🇸

Boston University Psychiatry Research Center, Clinical Studies Unit, Boston, Massachusetts, United States

Open-label Clinical Trial of Lacosamide in ALS

Phase 1
Completed
Conditions
Interventions
First Posted Date
2017-06-14
Last Posted Date
2020-07-15
Lead Sponsor
Chiba University
Target Recruit Count
7
Registration Number
NCT03186040
Locations
🇯🇵

Chiba University Hospital, Chiba, Japan

Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus

First Posted Date
2016-04-04
Last Posted Date
2017-08-29
Lead Sponsor
Mid-Atlantic Epilepsy and Sleep Center, LLC
Registration Number
NCT02726867
Locations
🇺🇸

MidAtlantic Epilepsy and Sleep Center, Bethesda, Maryland, United States

Study to Investigate Safety and Tolerability of Intravenous Lacosamide in Children.

Phase 2
Completed
Conditions
Interventions
First Posted Date
2016-03-17
Last Posted Date
2023-02-23
Lead Sponsor
UCB BIOSCIENCES, Inc.
Target Recruit Count
103
Registration Number
NCT02710890
Locations
🇺🇸

Ep0060 005, Dallas, Texas, United States

🇮🇹

Ep0060 503, Messina, Italy

🇺🇦

Ep0060 221, Kiev, Ukraine

and more 20 locations

A Clinical Study to Investigate the Long-term Use of Lacosamide as Monotherapy in Subjects Who Completed Study SP0994

Phase 3
Completed
Conditions
Interventions
First Posted Date
2015-10-21
Last Posted Date
2023-06-06
Lead Sponsor
UCB Biopharma S.P.R.L.
Target Recruit Count
106
Registration Number
NCT02582866
Locations
🇨🇭

Sp1042 654, Biel, Switzerland

🇺🇦

Sp1042 625, Odesa, Ukraine

🇵🇱

Sp1042 340, Katowice, Poland

and more 43 locations

Efficacy and Safety of Lacosamide as Adjunctive Therapy in Subjects ≥1 Month to <4 Years With Partial-onset Seizures

First Posted Date
2015-06-23
Last Posted Date
2021-07-01
Lead Sponsor
UCB BIOSCIENCES, Inc.
Target Recruit Count
255
Registration Number
NCT02477839
Locations
🇨🇳

Sp0967 537, Shenzhen, China

🇬🇷

Sp0967 542, Athens, Greece

🇷🇺

Sp0967 456, Nizhny Novgorod, Russian Federation

and more 85 locations

Comparative Trial of IV Lacosamide Versus Phenytoin for Seizure Management

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2015-04-06
Last Posted Date
2016-01-07
Lead Sponsor
Lawson Health Research Institute
Target Recruit Count
3
Registration Number
NCT02409433
Locations
🇨🇦

University Hospital, London, Ontario, Canada

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Effects of Lacosamide on Post-operative Opioid Requirements After a Total Hip Arthroplasty:

First Posted Date
2015-01-21
Last Posted Date
2016-08-26
Lead Sponsor
Indiana University School of Medicine
Registration Number
NCT02342977
Locations
🇺🇸

Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana, United States

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