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Ephedrine

Generic Name
Ephedrine
Brand Names
Akovaz, Bronkaid, Corphedra, Emerphed, Primatene, Rezipres
Drug Type
Small Molecule
Chemical Formula
C10H15NO
CAS Number
299-42-3
Unique Ingredient Identifier
GN83C131XS
Background

Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.

Indication

Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.

Associated Conditions
Allergic Reaction, Bronchial Asthma, Common Cold, Cough, Depression, Fever, General Anesthesia Induced Hypotension, Headache, Joint Pain, Myasthenia Gravis, Narcolepsy, Nasal Congestion, Rhinorrhoea, Sore Throat, Dry cough
Associated Therapies
-
Clinical Trials
Related News

Ephedrine, Phenylephrine and Metaraminol Effects on Maternal Cardiac Output, Uterine Blood Flow and Fetal Circulation

Not Applicable
Conditions
Preeclampsia
Interventions
Drug: Phenylephrine
Drug: Metaraminol
Drug: Ephedrine
First Posted Date
2014-09-19
Last Posted Date
2014-09-19
Lead Sponsor
University of Sao Paulo General Hospital
Target Recruit Count
60
Registration Number
NCT02245191
Locations
🇧🇷

University of São Paulo, São Paulo, Brazil

Prophylaxis Ephedrine or Ondansetron Prevents Hypotension After Spinal Anesthesia for Cesarean Section

Not Applicable
Completed
Conditions
Anesthesia; Adverse Effect, Spinal and Epidural
Interventions
Drug: Placebo
Drug: Ondansetron
Drug: Ephedrine
First Posted Date
2014-07-18
Last Posted Date
2015-03-17
Lead Sponsor
Mahidol University
Target Recruit Count
168
Registration Number
NCT02194192
Locations
🇹🇭

Siriraj Hospital, Mahidol University, Bangkok, Thailand

Prophylactic Ephedrine and Combined Spinal Epidurals for Labor

Phase 4
Completed
Conditions
Labor Pain
Interventions
Drug: Placebo
Drug: Ephedrine
First Posted Date
2014-02-14
Last Posted Date
2015-07-03
Lead Sponsor
Sharp HealthCare
Target Recruit Count
710
Registration Number
NCT02062801
Locations
🇺🇸

Sharp Mary Birch Hospital for Women and Newborns, San Diego, California, United States

Effect on Energy Metabolism at Cellular Level of Diet Plus Treatment With Ephedrine and Caffeine in Obesity

Phase 3
Completed
Conditions
Obesity
Interventions
Drug: Placebo
Drug: Caffeine
Drug: Ephedrine
Other: Hypocaloric diet
First Posted Date
2014-01-29
Last Posted Date
2014-01-29
Lead Sponsor
Istituto Auxologico Italiano
Target Recruit Count
13
Registration Number
NCT02048215
Locations
🇮🇹

Istituto Auxologico Italiano -Ospedale San Giuseppe, Verbania, VB, Italy

Phenylephrine Versus Ephedrine in Pre-eclampsia

Phase 4
Terminated
Conditions
Pre-eclampsia
Interventions
Drug: Ephedrine
Drug: Phenylephrine
First Posted Date
2014-01-01
Last Posted Date
2020-10-14
Lead Sponsor
Duke University
Target Recruit Count
13
Registration Number
NCT02025426
Locations
🇺🇸

Duke University Medical Center, Durham, North Carolina, United States

Intrathecal Levobupivacaine With Opioids for Caesarean Section

Phase 3
Completed
Conditions
Elective Caesarean Section Surgeries
Interventions
Drug: Control Group Chirocaine
Drug: Group Fentanyl
Drug: Group sufentanil
Drug: Ephedrine
Drug: Atropine sulfate
Drug: Propofol
Drug: Metoclopramide
Drug: Diphenhydramine
Drug: pethidine hydrochloride
Drug: Diclofenac sodium
First Posted Date
2013-05-21
Last Posted Date
2013-05-21
Lead Sponsor
Baskent University
Target Recruit Count
93
Registration Number
NCT01858090
Locations
🇹🇷

Baskent University School of Medicine Adana Teaching and Research Hospital, Adana, Turkey

The Oxygenation of the Brain During Caesarean Section

Phase 4
Completed
Conditions
Complications; Cesarean Section
Interventions
Drug: Ephedrine
Drug: Phenylephrine
First Posted Date
2012-01-13
Last Posted Date
2012-08-07
Lead Sponsor
Naestved Hospital
Target Recruit Count
24
Registration Number
NCT01509521
Locations
🇩🇰

Naestved Hospital, Naestved, Denmark

Maternal and Neonatal Outcomes of the Use of Vasopressors to Treat Hypotension During Spinal Anesthesia for Cesarean

Phase 3
Withdrawn
Conditions
Preeclampsia
Pregnancy Toxemias
First Posted Date
2011-10-13
Last Posted Date
2016-09-07
Lead Sponsor
Instituto Materno Infantil Prof. Fernando Figueira
Registration Number
NCT01451060
Locations
🇧🇷

Instituto de Medicina Integral Professor Fernando Figueira, Recife, Pernambuco, Brazil

Ephedrine vs Phenylephrine - ECG Changes

Phase 4
Terminated
Conditions
Spinal Anesthesia
Pregnancy
Interventions
Drug: Phenylephrine
Drug: Ephedrine
First Posted Date
2010-11-19
Last Posted Date
2016-10-26
Lead Sponsor
University College London Hospitals
Target Recruit Count
29
Registration Number
NCT01243970
Locations
🇬🇧

University College London Hospital, London, United Kingdom

Activation of Cervical and Upper Thoracic Brown Adipose Tissue in Humans Via Beta-adrenergic Stimulation

Not Applicable
Completed
Conditions
Obesity
Interventions
Drug: ephedrine hydrochloride
First Posted Date
2009-11-18
Last Posted Date
2013-02-15
Lead Sponsor
Bayside Health
Target Recruit Count
25
Registration Number
NCT01015794
Locations
🇦🇺

Alfred Hospital Heart Centre, Prahran, Victoria, Australia

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