Levetiracetam
- Generic Name
- Levetiracetam
- Brand Names
- Elepsia, Keppra, Matever, Roweepra, Spritam, Levetiracetam Accord, Levetiracetam Teva, Levetiracetam Actavis, Levetiracetam ratiopharm, Levetiracetam Sun, Levetiracetam Actavis Group, Levetiracetam Hospira
- Drug Type
- Small Molecule
- Chemical Formula
- C8H14N2O2
- CAS Number
- 102767-28-2
- Unique Ingredient Identifier
- 44YRR34555
- Background
Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs). Levetiracetam possesses a wide therapeutic index and little-to-no potential t...
- Indication
Levetiracetam is indicated as an adjunctive therapy in the treatment of partial onset seizures in epileptic patients who are one month of age and older. Additionally, it is indicated as an adjunct in the treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy who are 12 years of age and older, and in primary generalized tonic-clonic seiz...
- Associated Conditions
- Epilepsies, Generalized Tonic-Clonic Seizures, Partial-Onset Seizures, Myoclonic seizures
- Associated Therapies
- -
Levetiracetam Versus Valproate in Idiopathic Generalized Tonic-clonic Seizures
- Conditions
- Interventions
- First Posted Date
- 2019-05-07
- Last Posted Date
- 2022-02-17
- Lead Sponsor
- Mazandaran University of Medical Sciences
- Target Recruit Count
- 103
- Registration Number
- NCT03940326
- Locations
- 🇮🇷
Bu Ali Sina Hospital, Sari, Mazandaran, Iran, Islamic Republic of
Treating Hyperexcitability in AD With Levetiracetam
- Conditions
- Interventions
- First Posted Date
- 2019-03-15
- Last Posted Date
- 2024-12-05
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 85
- Registration Number
- NCT03875638
- Locations
- 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil
- Conditions
- Interventions
- First Posted Date
- 2018-10-03
- Last Posted Date
- 2020-06-04
- Lead Sponsor
- UCB Biopharma S.P.R.L.
- Target Recruit Count
- 31
- Registration Number
- NCT03695094
- Locations
- 🇳🇱
Up0070 401, Leiden, Netherlands
🇧🇬Up0070 101, Sofia, Bulgaria
Pharmacokinetics of Antiepileptics in Patients on CRRT
- First Posted Date
- 2018-08-16
- Last Posted Date
- 2021-10-05
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 18
- Registration Number
- NCT03632915
- Locations
- 🇺🇸
University of Maryland Medical Center, Baltimore, Maryland, United States
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
- Conditions
- Interventions
- Drug: Tranexamic acid (TXA)Drug: HydrocodoneDrug: labetalolDrug: metforminDrug: nifedipineDrug: oxycodoneDrug: clindamycinDrug: azithromycinDrug: escitalopramDrug: sertralineDrug: CiprofloxacinDrug: ondansetronDrug: DoxycyclineDrug: LevofloxacinDrug: MethylphenidateDrug: CitalopramDrug: SumatriptanDrug: CyclobenzaprineDrug: FurosemideDrug: RosuvastatinDrug: GabapentinDrug: HydrochlorothiazideDrug: HydroxyureaDrug: TrazodoneDrug: TopiramateDrug: ValganciclovirDrug: RemdesivirDrug: VenlafaxineDrug: VerapamilDrug: FluvoxamineDrug: AnakinraDrug: TocilizumabDrug: AmoxicillinDrug: BupropionDrug: BuprenorphineDrug: LevetiracetamDrug: ParoxetineDrug: Duloxetine
- First Posted Date
- 2018-04-27
- Last Posted Date
- 2024-12-17
- Lead Sponsor
- Duke University
- Target Recruit Count
- 1600
- Registration Number
- NCT03511118
- Locations
- 🇺🇸
Northwestern University, Chicago, Illinois, United States
🇺🇸Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, Illinois, United States
🇺🇸Loma Linda University Health, Loma Linda, California, United States
An Investigation of Levetiracetam in Alzheimer's Disease
- Conditions
- Interventions
- First Posted Date
- 2018-04-05
- Last Posted Date
- 2024-04-24
- Lead Sponsor
- University of Oxford
- Target Recruit Count
- 8
- Registration Number
- NCT03489044
- Locations
- 🇬🇧
Nuffield Department of Clinical Neuroscience, Oxford, Oxfordshire, United Kingdom
Seizure Prophylaxis in Patients With Glioma or Brain Metastasis
- Conditions
- Interventions
- First Posted Date
- 2018-02-19
- Last Posted Date
- 2023-04-13
- Lead Sponsor
- Duke University
- Target Recruit Count
- 4
- Registration Number
- NCT03436433
- Locations
- 🇺🇸
Duke Comprehensive Cancer Center, Durham, North Carolina, United States
A Study of Levetiracetam as Monotherapy or Adjunctive Treatment of Partial Seizures in Pediatric Epileptic Subjects Ranging From 1 Month to Less Than 4 Years of Age
- First Posted Date
- 2017-11-13
- Last Posted Date
- 2024-07-23
- Lead Sponsor
- UCB Japan Co. Ltd.
- Target Recruit Count
- 38
- Registration Number
- NCT03340064
- Locations
- 🇯🇵
Ep0100 20, Kobe, Japan
🇯🇵EP0100 3, Hamamatsu, Japan
🇯🇵Ep0100 15, Fukuoka, Japan
Population Pharmacokinetics of Antiepileptic in Pediatrics
- Conditions
- Interventions
- Biological: Valproic acidBiological: carbamazepineBiological: phenobarbitalBiological: phenytoinBiological: levetiracetamBiological: lamotrigineBiological: topiramateBiological: oxcarbazepineBiological: stiripentolBiological: clobazamBiological: brivaracétamBiological: felbamateBiological: lacosamideBiological: rufinamideBiological: gabapentineBiological: pregabalineBiological: sultiameBiological: tiagabineBiological: vigabatrineBiological: mesuximideBiological: primidoneBiological: perampanelBiological: ethosuximideBiological: zonisamideBiological: cannabidiolOther: genetic polymorphisms
- First Posted Date
- 2017-06-22
- Last Posted Date
- 2024-10-30
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 1000
- Registration Number
- NCT03196466
- Locations
- 🇫🇷
AP-HP Cochin, Paris, France
Levetiracetam in Early Psychosis
- Conditions
- Interventions
- First Posted Date
- 2017-04-26
- Last Posted Date
- 2022-11-21
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 48
- Registration Number
- NCT03129360
- Locations
- 🇺🇸
New York University School of Medicine, New York, New York, United States
Drug Development Updates
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