Levetiracetam

Generic Name: Levetiracetam

Brand Names: Elepsia, Keppra, Matever, Roweepra, Spritam, Levetiracetam Accord, Levetiracetam Teva, Levetiracetam Actavis, Levetiracetam ratiopharm, Levetiracetam Sun, Levetiracetam Actavis Group, Levetiracetam Hospira

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₄N_₂O_₂

CAS Number: 102767-28-2

Unique Ingredient Identifier: 44YRR34555

Background: Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs). Levetiracetam possesses a wide therapeutic index and little-to-no potential t...

Indication: Levetiracetam is indicated as an adjunctive therapy in the treatment of partial onset seizures in epileptic patients who are one month of age and older. Additionally, it is indicated as an adjunct in the treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy who are 12 years of age and older, and in primary generalized tonic-clonic seiz...

Associated Conditions: Epilepsies, Generalized Tonic-Clonic Seizures, Partial-Onset Seizures, Myoclonic seizures

Associated Therapies: -

Clinical Trials

Efficacy of Levetiracetam in Control of Neonatal Seizures Guided by an EEG

Phase 4

Conditions: Neonatal Seizures

Interventions: Drug: Levetiracetam
Drug: Phenobarbital

First Posted Date: 2017-04-11

Last Posted Date: 2017-04-11

Lead Sponsor: Cairo University

Target Recruit Count: 40

Registration Number: NCT03107507

Locations: 🇪🇬
Cairo University Children's Hospital (Abulreesh), Cairo Governorate, Egypt

Does Short-Term Anti-Seizure Prophylaxis After Traumatic Brain Injury Decrease Seizure Rates?

Phase 4

Conditions: Seizures
Traumatic Brain Injury

Interventions: Drug: Levetiracetam

First Posted Date: 2017-02-15

Last Posted Date: 2019-08-06

Lead Sponsor: Loyola University

Target Recruit Count: 2300

Registration Number: NCT03054285

Locations: 🇺🇸
Loyola University Medical Center, Maywood, Illinois, United States

Seizure Treatment in Glioma

Phase 4

Recruiting

Conditions: Glioma

Interventions: Drug: Levetiracetam
Drug: Valproic Acid

First Posted Date: 2017-02-09

Last Posted Date: 2024-03-13

Lead Sponsor: Leiden University Medical Center

Target Recruit Count: 120

Registration Number: NCT03048084

Locations: 🇳🇱
VU University Medical Center, Amsterdam, Netherlands
🇳🇱
Medisch Spectrum Twente, Enschede, Netherlands
🇳🇱
Leiden University Medical Center, Leiden, Netherlands

and more 2 locations

Reducing Hippocampal Hyperactivity and Improving Cognition in Schizophrenia

Phase 1

Completed

Conditions: Schizophrenia

Interventions: Drug: Levetiracetam
Drug: Placebo

First Posted Date: 2017-01-27

Last Posted Date: 2024-08-20

Lead Sponsor: VA Office of Research and Development

Target Recruit Count: 67

Registration Number: NCT03034356

Locations: 🇺🇸
Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado, United States

Validation of the Role of Levetiracetam for Newly Diagnosed GBM Patients

Phase 2

Conditions: Glioblastoma Multiforme

Interventions: Drug: levetiracetam

First Posted Date: 2016-06-28

Last Posted Date: 2016-06-28

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 73

Registration Number: NCT02815410

Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus

Phase 3

Withdrawn

Conditions: Status Epilepticus
Epilepsy

Interventions: Drug: Ketamine
Drug: levetiracetam
Drug: lacosamide
Drug: Phenobarbital

First Posted Date: 2016-04-04

Last Posted Date: 2017-08-29

Lead Sponsor: Mid-Atlantic Epilepsy and Sleep Center, LLC

Registration Number: NCT02726867

Locations: 🇺🇸
MidAtlantic Epilepsy and Sleep Center, Bethesda, Maryland, United States

Effects of Low-dose Levetiracetam on Clinical Symptoms, Cognition and Hippocampal Hyperactivity in Schizophrenia

Not Applicable

Recruiting

Conditions: Schizophrenia

Interventions: Drug: Levetiracetam
Drug: Placebo

First Posted Date: 2016-01-06

Last Posted Date: 2024-02-05

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 30

Registration Number: NCT02647437

Locations: 🇺🇸
University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States

Prospective Cohort Study on the Efficacy of Vagus Nerve Stimulation for Children and Adolescents With Epilepsy(PVNS-CAE)

Conditions: Epileptic Encephalopathy

First Posted Date: 2015-11-13

Last Posted Date: 2016-10-13

Lead Sponsor: Beijing Pins Medical Co., Ltd

Target Recruit Count: 1

Registration Number: NCT02603991

Locations: 🇨🇳
Beijing Tiantan Hospital, Beijing, Beijing, China

A Brain Imaging Study With Positron Emission Tomography and the Radiotracer [11C]UCB-J to Estimate How Fast Brivaracetam and Levetiracetam Enter the Brain in Healthy Volunteers

Phase 1

Completed

Conditions: Healthy Volunteers

Interventions: Radiation: [11C]UCB-J
Drug: Levetiracetam
Drug: Brivaracetam

First Posted Date: 2015-11-11

Last Posted Date: 2017-10-30

Lead Sponsor: UCB Pharma

Target Recruit Count: 13

Registration Number: NCT02602860

Locations: 🇺🇸
Ep0074 001, New Haven, Connecticut, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3

Terminated

Conditions: Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders

Interventions: Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium

First Posted Date: 2015-03-02

Last Posted Date: 2018-02-28

Lead Sponsor: Hannover Medical School

Target Recruit Count: 407

Registration Number: NCT02374567

Locations: 🇩🇪
Bezirkskrankenhaus Augsburg, Augsburg, Germany
🇩🇪
Krankenhaus Hedwigshöhe, Berlin, Germany
🇩🇪
Hannover Medical School, Hannover, Germany

and more 2 locations

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