DeepMed Research

Pimozide

Generic Name: Pimozide

Brand Names: Orap

Drug Type: Small Molecule

Chemical Formula: C_₂₈H_₂₉F_₂N_₃O

CAS Number: 2062-78-4

Unique Ingredient Identifier: 1HIZ4DL86F

Background: A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)

Indication: 适用于急、慢性精神分裂症，对精神分裂症的阴性症状疗效较好，亦可用于治疗偏执状态、亨廷顿病、抽动秽语综合征、躁狂症、神经性厌食、青少年行为障碍等。

Associated Conditions: Delusional Parasitosis, Tics

Clinical Trials

Electrophysiological Effects of Potential QT Prolonging Drugs

Phase 1

Completed

Conditions: Drug-induced QT Prolongation
Pharmacokinetics
Pharmacodynamics

Interventions: Drug: Placebo (Part 2)
Drug: Moxifloxacin and Cobicistat
Drug: Placebo (Part 1)
Drug: Clarithromycin
Drug: Pimozide
Drug: Moxifloxacin
Drug: Cobicistat

First Posted Date: 2023-02-08

Last Posted Date: 2023-06-22

Lead Sponsor: Food and Drug Administration (FDA)

Target Recruit Count: 44

Registration Number: NCT05716854

Locations: 🇺🇸
Spaulding Clinical Research, West Bend, Wisconsin, United States

Treatment for Post Acute COVID-19 Syndrome

Not Applicable

Conditions: Tinnitus, Subjective

Interventions: Drug: Pimozide 1 MG

First Posted Date: 2022-08-19

Last Posted Date: 2022-08-22

Lead Sponsor: Applied Biology, Inc.

Target Recruit Count: 50

Registration Number: NCT05507372

A Clinical Trial of Pimozide in Patients With Amyotrophic Lateral Sclerosis (ALS)

Phase 2

Conditions: ALS
Amyotrophic Lateral Sclerosis

Interventions: Drug: Pimozide 2mg/day (current) or 4 mg/day (study initiation)
Drug: Placebo Oral Tablet

First Posted Date: 2017-09-05

Last Posted Date: 2020-05-28

Lead Sponsor: University of Calgary

Target Recruit Count: 100

Registration Number: NCT03272503

Locations: 🇨🇦
Dr. Lawrence Korngut -South Health Campus, Calgary, Alberta, Canada
🇨🇦
Dr. Colleen O'Connell - Stan Cassidy Centre for Rehabilitation, Fredericton, New Brunswick, Canada
🇨🇦
Dr. Genevieve Matte, Montréal, Quebec, Canada

and more 6 locations

Family Intervention in Recent Onset Schizophrenia Treatment (FIRST)

Completed

Conditions: Schizophrenia

Interventions: Other: Caregiver psycho-education and skills training
Other: Caregiver support available at the study site
Drug: Paliperidone palmitate
Drug: Chlorpromazine
Drug: Droperidol
Drug: Fluphenazine
Drug: Haloperidol
Drug: Loxapine
Drug: Perphenazine
Drug: Pimozide
Drug: Prochlorperazine
Drug: Thiothixene
Drug: Thioridazine
Drug: Trifluoperazine
Drug: Aripiprazole
Drug: Asenapine
Drug: Clozapine
Drug: Iloperidone
Drug: Olanzapine
Drug: Paliperidone
Drug: Quetiapine
Drug: Risperidone
Drug: Ziprasidone

First Posted Date: 2015-11-09

Last Posted Date: 2019-01-23

Lead Sponsor: Janssen Scientific Affairs, LLC

Target Recruit Count: 296

Registration Number: NCT02600741

A Registry-Based Clinical Trial of Pimozide in Patients With Neuromuscular Junction Transmission Dysfunction Due to ALS

Phase 2

Conditions: Amyotrophic Lateral Sclerosis (ALS)

Interventions: Drug: Placebo (Lactose tablet)
Drug: Pimozide 4 mg per day
Drug: Pimozide 2 mg per day

First Posted Date: 2015-06-04

Last Posted Date: 2016-10-26

Lead Sponsor: University of Calgary

Target Recruit Count: 25

Registration Number: NCT02463825

Locations: 🇨🇦
South Health Campus, Calgary, Alberta, Canada

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3

Terminated

Conditions: Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders

Interventions: Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium

First Posted Date: 2015-03-02

Last Posted Date: 2018-02-28

Lead Sponsor: Hannover Medical School

Target Recruit Count: 407

Registration Number: NCT02374567

Locations: 🇩🇪
Bezirkskrankenhaus Augsburg, Augsburg, Germany
🇩🇪
Krankenhaus Hedwigshöhe, Berlin, Germany
🇩🇪
Hannover Medical School, Hannover, Germany

and more 2 locations

Evaluation of the Necessity of Long-term Pharmacological Treatment With Antipsychotics in Schizophrenic Patients

Phase 4

Completed

Conditions: Schizophrenia and Disorders With Psychotic Features
Schizoaffective Disorders
Schizophrenia

Interventions: Drug: Olanzapine
Drug: Amisulpride
Drug: Risperidone
Drug: Haloperidol
Drug: Quetiapine
Drug: Perphenazine
Drug: Sulpiride
Drug: bromperidol
Drug: Zuclopenthixol
Drug: Thioridazine
Drug: Paliperidone
Drug: Ziprasidone
Drug: Benperidol
Drug: Fluspirilene
Drug: Pimozide
Drug: Perazine
Drug: Fluphenazine
Drug: Flupentixole
Drug: Sertindole

First Posted Date: 2014-12-04

Last Posted Date: 2018-10-11

Lead Sponsor: Technical University of Munich

Target Recruit Count: 21

Registration Number: NCT02307396

Locations: 🇩🇪
Psychiatrische Klinik und Poliklinik fuer Psychiatrie und Psychotherapie der Technischen Universitaet Muenchen am Klinikum rechts der Isar, Munich, Bavaria, Germany

Efficacy of Pimozide Augmentation for Clozapine Partial Response

Phase 2

Completed

Conditions: Schizophrenia

Interventions: Drug: Pimozide
Drug: placebo

First Posted Date: 2006-09-11

Last Posted Date: 2016-03-04

Lead Sponsor: Yale University

Target Recruit Count: 28

Registration Number: NCT00374244

Locations: 🇺🇸
Connecticut Mental Health Center, New Haven, Connecticut, United States
🇺🇸
VA Connecticut Healthcare System, West Haven, Connecticut, United States

Effectiveness of Pimozide in Augmenting the Effects of Clozapine in the Treatment of Schizophrenia

Phase 4

Completed

Conditions: Schizophrenia
Psychotic Disorders

Interventions: Drug: Placebo
Drug: Pimozide

First Posted Date: 2005-09-12

Last Posted Date: 2015-04-09

Lead Sponsor: Icahn School of Medicine at Mount Sinai

Target Recruit Count: 76

Registration Number: NCT00158223

Locations: 🇺🇸
Pilgrim Psychiatric Center, W. Brentwood, New York, United States
🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States
🇺🇸
Manhattan Psychiatric Center, New York, New York, United States

Phase II Pilot Controlled Study of Short Vs Longer Term Pimozide (Orap) Therapy in Tourette Syndrome

Phase 2

Completed

Conditions: Tourette Syndrome

First Posted Date: 2000-02-25

Last Posted Date: 2005-06-24

Lead Sponsor: National Center for Research Resources (NCRR)

Target Recruit Count: 20

Registration Number: NCT00004652

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