Haloperidol
- Generic Name
- Haloperidol
- Brand Names
- Haldol
- Drug Type
- Small Molecule
- Chemical Formula
- C21H23ClFNO2
- CAS Number
- 52-86-8
- Unique Ingredient Identifier
- J6292F8L3D
- Background
Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the dopamine receptor (mainly D2), particularl...
- Indication
Haloperidol is indicated for a number of conditions including for the treatment of schizophrenia, for the manifestations of psychotic disorders, for the control of tics and vocal utterances of Tourette’s Disorder in children and adults, for treatment of severe behavior problems in children of combative, explosive hyperexcitability (which cannot be accounted ...
- Associated Conditions
- Aggression, Delirium, Gilles de la Tourette's Syndrome, Huntington's Disease (HD), Nausea and vomiting, Obsessive Compulsive Disorder (OCD), Psychosis, Schizophrenia, Severe Disruptive Behaviour Disorders, Severe Hyperactivity
- Associated Therapies
- -
Haloperidol Prophylaxis in Cardiac Surgery for Patients at Risk for Delirium
- First Posted Date
- 2013-05-24
- Last Posted Date
- 2016-09-16
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 25
- Registration Number
- NCT01862302
- Locations
- 🇨🇦
Hamilton General Site, Hamilton, Ontario, Canada
Trial Comparing Haloperidol, Quetiapine and Placebo in the Pharmacological Treatment of Delirium
- First Posted Date
- 2013-03-14
- Last Posted Date
- 2018-02-09
- Target Recruit Count
- 107
- Registration Number
- NCT01811459
- Locations
- 🇨🇦
Centre hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada
Haloperidol vs. Valproate in Agitation
- First Posted Date
- 2012-12-17
- Last Posted Date
- 2013-01-08
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Target Recruit Count
- 56
- Registration Number
- NCT01750541
- Locations
- 🇮🇷
Department of Emergency Medicine, Imam Hossein Hospital, Tehran, Iran, Islamic Republic of
Evidence of Haloperidol Absorption After Topical Administration
- First Posted Date
- 2012-09-13
- Last Posted Date
- 2016-03-17
- Lead Sponsor
- Eric E. Prommer
- Registration Number
- NCT01684969
Early Recognition and Optimal Treatment of Delirium in Patients With Advanced Cancer
- Conditions
- Interventions
- First Posted Date
- 2012-02-27
- Last Posted Date
- 2017-04-07
- Lead Sponsor
- Amsterdam UMC, location VUmc
- Target Recruit Count
- 101
- Registration Number
- NCT01539733
- Locations
- 🇳🇱
VU University Medical Center, Amsterdam, Netherlands
🇳🇱Spaarne Hospital, Hoofddorp, Netherlands
Haloperidol Prophylaxis in Older Emergency Department Patients
- First Posted Date
- 2012-02-09
- Last Posted Date
- 2015-11-26
- Lead Sponsor
- Amsterdam UMC, location VUmc
- Target Recruit Count
- 242
- Registration Number
- NCT01530308
- Locations
- 🇳🇱
Spaarne Ziekenhuis, Hoofddorp, Noord Holland, Netherlands
🇳🇱VUmc, Amsterdam, Noord-Holland, Netherlands
🇳🇱Medical Center Alkmaar, Alkmaar, Netherlands
Pre-hospital Agitation and Sedation Trial: A Randomized Controlled Trial of Haloperidol Versus Midazolam for the Sedation of the Agitated Patient
- First Posted Date
- 2011-12-29
- Last Posted Date
- 2019-07-24
- Lead Sponsor
- Catholic Health East
- Target Recruit Count
- 10
- Registration Number
- NCT01501123
- Locations
- 🇺🇸
Mercy Catholic Medical Center, Darby, Pennsylvania, United States
Typical Versus Atypical Antipsychotics; Occupation of Striatal Receptors and the Appearance of Extrapyramidal Symptomatology, in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2010-12-15
- Last Posted Date
- 2011-04-18
- Lead Sponsor
- Hospital Clinic of Barcelona
- Target Recruit Count
- 24
- Registration Number
- NCT01259973
- Locations
- 🇪🇸
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
🇪🇸Hospital Clinic of Barcelona, Barcelona, Spain
The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA (MIND-USA) Study
- Conditions
- Interventions
- First Posted Date
- 2010-09-29
- Last Posted Date
- 2019-11-18
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 566
- Registration Number
- NCT01211522
- Locations
- 🇺🇸
University of Michigan Health System, Ann Arbor, Michigan, United States
🇺🇸University of Washington, Seattle, Washington, United States
🇺🇸Denver Health/University of Colorado Health Sciences Center, Denver, Colorado, United States
Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2010-09-17
- Last Posted Date
- 2017-11-17
- Lead Sponsor
- Virginia Commonwealth University
- Target Recruit Count
- 11
- Registration Number
- NCT01204255
- Locations
- 🇺🇸
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, United States
Drug Development Updates
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