Mepivacaine

Generic Name
Mepivacaine
Brand Names
Carbocaine, Carbocaine With Neocobefrin, Isocaine, Isocaine With Levonordefrin, Polocaine, Scandonest, Scandonest L, Scandonest Plain
Drug Type
Small Molecule
Chemical Formula
C15H22N2O
CAS Number
96-88-8
Unique Ingredient Identifier
B6E06QE59J
Background

A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)

Indication

For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.

Associated Conditions
Anaemia vitamin B6 deficiency, Anemia, Blood Loss Anemia, Diabetic Peripheral Neuropathy (DPN)
Associated Therapies
Local Anaesthesia therapy, Regional nerve block therapy, Lumbar epidural anesthesia therapy
Clinical Trials
Related News

Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty

First Posted Date
2019-02-12
Last Posted Date
2021-08-12
Lead Sponsor
Mayo Clinic
Target Recruit Count
154
Registration Number
NCT03838874
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Comparative Evaluation of the Effect of Prophylactic Intraligamentary Injection of Dexamethasone and Piroxicam on Postoperative Pain in Teeth With Symptomatic Irreversible Pulpitis

First Posted Date
2018-11-19
Last Posted Date
2018-11-23
Lead Sponsor
Cairo University
Target Recruit Count
42
Registration Number
NCT03745105

Femoral Peri-arterial Local Anesthetic Injection Decreases Tourniquet Associated Ischemic Hypertension

First Posted Date
2018-01-04
Last Posted Date
2021-05-05
Lead Sponsor
Duke University
Target Recruit Count
31
Registration Number
NCT03390426
Locations
🇺🇸

Duke University Hospital, Durham, North Carolina, United States

Chloroprocaine Spinal for Outpatient Knee Surgery

First Posted Date
2017-12-07
Last Posted Date
2022-04-20
Lead Sponsor
Hospital for Special Surgery, New York
Target Recruit Count
39
Registration Number
NCT03365752
Locations
🇺🇸

Hospital for Special Surgery, New York, New York, United States

Mepivacaine vs. Bupivacaine Spinal Anesthetic in Total Knee Arthroplasty

First Posted Date
2016-12-02
Last Posted Date
2017-03-27
Lead Sponsor
Henry Ford Health System
Target Recruit Count
32
Registration Number
NCT02980926
Locations
🇺🇸

Henry Ford West Bloomfield, West Bloomfield Township, Michigan, United States

Decision Support for Intraoperative Low Blood Pressure

Not Applicable
Completed
Conditions
Hypotension
Interventions
Procedure: Attending real-time decision support
Procedure: In-room real-time decision support
Procedure: Attending feedback emails
Procedure: In-room provider feedback emails
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Device: Pager system
Procedure: Central neuraxial anesthesia
Procedure: Non-cardiac surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Desflurane
Drug: Isoflurane
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
Drug: Epinephrine
Drug: Dobutamine
Drug: Dopamine
Drug: Isoproterenol
Drug: Milrinone
Drug: Atropine
Drug: Glycopyrrolate
Drug: Vasopressin
Drug: Terlipressin
Drug: Sodium Chloride 0.9%
Drug: Ringer's lactate
Drug: Hydroxyethyl starch solutions
Drug: Fresh Frozen Plasma
Drug: Packed Red Blood Cells
Drug: Albumin solutions
Drug: Plasma-Lyte
Drug: Lidocaine
Drug: Bupivacaine
Drug: Levobupivacaine
Drug: Ropivacaine
Drug: Mepivacaine
Drug: Tetracaine
Drug: Prilocaine
Drug: Procaine
Drug: Chloroprocaine
Drug: Benzocaine
Drug: Articaine
First Posted Date
2016-04-04
Last Posted Date
2019-05-16
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
22435
Registration Number
NCT02726620
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Trial Evaluating Postop Pain and Muscle Strength Among Regional Anesthesia Techniques for Ambulatory ACL Reconstruction

First Posted Date
2015-10-22
Last Posted Date
2019-12-11
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
59
Registration Number
NCT02584452
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

The Impact of Chloroprocaine 3% for Ambulatory Foot Surgery on Perioperative Process Costs

First Posted Date
2015-04-02
Last Posted Date
2020-03-11
Lead Sponsor
Ospedale Regionale Bellinzona e Valli
Target Recruit Count
100
Registration Number
NCT02406703

Spinal Anesthesia Versus Combined Sciatic-femoral Nerve Block for Outpatient Knee Arthroscopy

First Posted Date
2015-03-10
Last Posted Date
2015-05-08
Lead Sponsor
ASST Gaetano Pini-CTO
Target Recruit Count
100
Registration Number
NCT02384915
Locations
🇮🇹

Istituto Ortopedico G. Pini, Milan, Milano, Italy

Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis

First Posted Date
2014-04-10
Last Posted Date
2014-10-31
Lead Sponsor
Daniel Chavarría Bolaños
Target Recruit Count
56
Registration Number
NCT02110966
Locations
🇲🇽

Endodontics Master Degree program, Dentistry Faculty, San Luis Potosi University, San Luis Potosi, Mexico

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