Sertraline

Generic Name: Sertraline

Brand Names: Zoloft

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₇Cl_₂N

CAS Number: 79617-96-2

Unique Ingredient Identifier: QUC7NX6WMB

Background: Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as Citalopram and Fluoxetine. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects.
...

Indication: Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD). Common off-label uses for sertraline include the prevention of post stroke depression, generalized anxiety di...

Associated Conditions: Binge Eating Disorder (BED), Bulimia Nervosa, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Obsessive Compulsive Disorder (OCD), Panic Disorder, Post Traumatic Stress Disorder (PTSD), Premenstrual Dysphoric Disorder (PMDD), Social Anxiety Disorder (SAD)

Associated Therapies: -

Clinical Trials

Sequencing CBT for Child Anxiety: CBT Plus Sertraline Versus Switch to Sertraline

Phase 2

Terminated

Conditions: Anxiety Disorder of Adolescence

Interventions: Drug: Sertraline
Behavioral: Cognitive Behavioral Therapy

First Posted Date: 2013-11-07

Last Posted Date: 2016-05-16

Lead Sponsor: Yale University

Target Recruit Count: 1

Registration Number: NCT01977729

Locations: 🇺🇸
Yale Child Study Center, New Haven, Connecticut, United States

Interpersonal Psychotherapy for Treatment Resistant Depression

First Posted Date: 2013-07-11

Last Posted Date: 2013-07-11

Lead Sponsor: Hospital de Clinicas de Porto Alegre

Target Recruit Count: 74

Registration Number: NCT01896349

Locations: 🇧🇷
Federal University of Rio Grande do Sul / Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil

Frontal Hypoperfusion Effects on Antidepressant Outcomes in Late-Life Depression

Phase 4

Completed

Conditions: Major Depressive Disorder

Interventions: Drug: Sertraline

First Posted Date: 2013-07-11

Last Posted Date: 2017-07-21

Lead Sponsor: Vanderbilt University

Target Recruit Count: 31

Registration Number: NCT01896934

Locations: 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States

Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction?

Phase 4

Terminated

Conditions: Sexual Dysfunction
Major Depressive Disorder

Interventions: Drug: Vilazodone
Drug: Sertraline

First Posted Date: 2013-05-17

Last Posted Date: 2016-08-25

Lead Sponsor: Thomas Jefferson University

Target Recruit Count: 4

Registration Number: NCT01856127

Locations: 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
🇺🇸
University of Virginia, Charlottesville, Virginia, United States
🇺🇸
Thomas Jefferson University, Philadelphia, Pennsylvania, United States

Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis

Phase 3

Completed

Conditions: Cryptococcal Meningitis
Fungal Meningitis

Interventions: Drug: Sertraline

First Posted Date: 2013-03-01

Last Posted Date: 2020-06-09

Lead Sponsor: University of Minnesota

Target Recruit Count: 460

Registration Number: NCT01802385

Locations: 🇺🇬
Infectious Disease Institute, Kampala, Uganda
🇺🇬
Mbarara University of Science and Technology, Mbarara, Uganda

Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life Depression

Phase 4

Terminated

Conditions: Depression
Hypertension

Interventions: Drug: Sertraline
Drug: Candesartan

First Posted Date: 2013-02-18

Last Posted Date: 2016-10-20

Lead Sponsor: Vanderbilt University

Target Recruit Count: 1

Registration Number: NCT01794455

Locations: 🇺🇸
Vanderbilt Psychiatric Hospital, Nashville, Tennessee, United States

Algorithm Guided Treatment Strategies for Major Depressive Disorder

Phase 4

Conditions: Major Depressive Disorder

Interventions: Drug: Escitalopram
Drug: Fluoxetine
Drug: Mirtazapine
Drug: Citalopram
Other: modified electroconvulsive therapy
Other: repetitive transcranial magnetic stimulation
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Venlafaxine
Drug: Duloxetine
Drug: Bupropion
Drug: Trazodone

First Posted Date: 2013-01-10

Last Posted Date: 2013-01-10

Lead Sponsor: Shanghai Mental Health Center

Target Recruit Count: 1080

Registration Number: NCT01764867

Locations: 🇨🇳
Shanghai Mental Health Center, Shanghai, China

Late-life Depression and Cerebral Perfusion

Not Applicable

Withdrawn

Conditions: Depression

Interventions: Drug: Sertraline

First Posted Date: 2012-12-18

Last Posted Date: 2013-07-31

Lead Sponsor: Vanderbilt University

Registration Number: NCT01751828

Locations: 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States

Riluzole Augmentation Pilot in Depression (RAPID) Trial

Phase 2

Terminated

Conditions: Major Depressive Disorder

Interventions: Drug: Riluzole
Drug: Sertraline
Other: placebo

First Posted Date: 2012-10-10

Last Posted Date: 2019-08-28

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 21

Registration Number: NCT01703039

Locations: 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States

Verapamil vs. Sertraline for Vestibular Migraine & Chronic Subjective Dizziness

Phase 1

Completed

Conditions: Vestibular Migraine
Chronic Subjective Dizziness

Interventions: Drug: Sertraline
Drug: Verapamil

First Posted Date: 2012-08-21

Last Posted Date: 2015-08-24

Lead Sponsor: Mayo Clinic

Target Recruit Count: 32

Registration Number: NCT01669304

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

© Copyright 2024. All Rights Reserved by MedPath

Home Terms & Conditions Privacy Policy