Paroxetine

Generic Name
Paroxetine
Brand Names
Paxil, Pexeva
Drug Type
Small Molecule
Chemical Formula
C19H20FNO3
CAS Number
61869-08-7
Unique Ingredient Identifier
41VRH5220H
Background

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham. A unique feature of this...

Indication

Paroxetine is indicated for the management of depression, obsessive-compulsive disorder, panic disorder, social anxiety disorder, generalized anxiety disorder, posttraumatic stress disorder. One form of paroxetine, commercially known as Brisdelle, is used to manage mild to moderate vasomotor symptoms of menopause. Off-label, paroxetine may be used for the tr...

Associated Conditions
Generalized Anxiety Disorder, Irritable Bowel Syndrome (IBS), Major Depressive Disorder (MDD), Obsessive Compulsive Disorder (OCD), Panic Disorder, Post Traumatic Stress Disorder (PTSD), Premature Ejaculation, Premenstrual Dysphoric Disorder (PMDD), Social Anxiety Disorder (SAD), Vasomotor Symptoms Associated With Menopause
Associated Therapies
-
Clinical Trials
Related News

Study to Investigate the Effect of Paroxetine Mediated CYP2D6 Inhibition on the Pharmacokinetics of Tamsulosin in Healthy Male Volunteers

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: Tamsulosin
Drug: Paroxetine
First Posted Date
2014-10-15
Last Posted Date
2014-10-15
Lead Sponsor
Boehringer Ingelheim
Target Recruit Count
24
Registration Number
NCT02264184

Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene

First Posted Date
2014-09-12
Last Posted Date
2014-09-12
Lead Sponsor
HolsboerMaschmeyer NeuroChemie GmbH
Target Recruit Count
80
Registration Number
NCT02237937
Locations
🇩🇪

Max Planck Institute of Psychiatry, Munich, Bavaria, Germany

The Measurement-based Care in Patients With Depressive Disorder: A Randomized Controlled Trial

Phase 4
Completed
Conditions
Major Depressive Disorder
Interventions
Drug: Paroxetine
Drug: Mirtazapine
First Posted Date
2014-07-16
Last Posted Date
2014-07-16
Lead Sponsor
Capital Medical University
Target Recruit Count
164
Registration Number
NCT02191124
Locations
🇨🇳

Beijing Anding Hospital, Beijing, Beijing, China

A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects

First Posted Date
2014-06-26
Last Posted Date
2022-02-18
Lead Sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Target Recruit Count
56
Registration Number
NCT02174822
Locations
🇦🇺

Nucleus Network, Melbourne, Victoria, Australia

Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients

First Posted Date
2013-12-30
Last Posted Date
2022-09-09
Lead Sponsor
Shanghai Mental Health Center
Target Recruit Count
78
Registration Number
NCT02022709
Locations
🇨🇳

Shanghai Mental Health Center, Shanghai, Shanghai, China

Interpersonal Psychotherapy for Treatment Resistant Depression

First Posted Date
2013-07-11
Last Posted Date
2013-07-11
Lead Sponsor
Hospital de Clinicas de Porto Alegre
Target Recruit Count
74
Registration Number
NCT01896349
Locations
🇧🇷

Federal University of Rio Grande do Sul / Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil

Interaction Between Paroxetine and Telaprevir

First Posted Date
2013-04-26
Last Posted Date
2020-12-08
Lead Sponsor
Radboud University Medical Center
Target Recruit Count
3
Registration Number
NCT01841502
Locations
🇳🇱

Academic Medical Centre Amsterdam, Amsterdam, Netherlands

🇳🇱

Reinier de Graaf Groep, Delft, Netherlands

🇳🇱

University Medical Centre Groningen, Groningen, Netherlands

and more 4 locations

Algorithm Guided Treatment Strategies for Major Depressive Disorder

First Posted Date
2013-01-10
Last Posted Date
2013-01-10
Lead Sponsor
Shanghai Mental Health Center
Target Recruit Count
1080
Registration Number
NCT01764867
Locations
🇨🇳

Shanghai Mental Health Center, Shanghai, China

Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder

First Posted Date
2012-09-10
Last Posted Date
2017-06-28
Lead Sponsor
Emory University
Target Recruit Count
91
Registration Number
NCT01681849
Locations
🇺🇸

Emory University, Atlanta, Georgia, United States

Lithium Versus Paroxetine in Major Depression

Phase 4
Completed
Conditions
Major Depressive Disorder
Interventions
Drug: Lithium
Drug: Paroxetine
First Posted Date
2011-08-12
Last Posted Date
2020-07-16
Lead Sponsor
Nova Scotia Health Authority
Target Recruit Count
2
Registration Number
NCT01416220
Locations
🇨🇦

Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada

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