Phenytoin
- Generic Name
- Phenytoin
- Brand Names
- Dilantin, Phenytek
- Drug Type
- Small Molecule
- Chemical Formula
- C15H12N2O2
- CAS Number
- 57-41-0
- Unique Ingredient Identifier
- 6158TKW0C5
- Background
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants. Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as bipolar disorder, retina prote...
- Indication
Phenytoin is indicated to treat grand mal seizures, complex partial seizures, and to prevent and treat seizures during or following neurosurgery. Injectable phenytoin and Fosphenytoin, which is the phosphate ester prodrug formulation of phenytoin, are indicated to treat tonic-clonic status epilepticus, and for the prevention and treatment of seizures occurri...
- Associated Conditions
- Complex Partial Seizure Disorder, Generalized Tonic-Clonic Seizures, Grand Mal Status Epilepticus, Jacksonian epilepsy, Partial-Onset Seizures, Petit Mal Epilepsy, Seizure Disorder, Post Traumatic, Seizures, Status; Epilepticus, Tonic-clonic, Temporal Lobe Epilepsy (TLE), Convulsive disorders
- Associated Therapies
- -
Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old.
- First Posted Date
- 2011-11-23
- Last Posted Date
- 2023-03-02
- Lead Sponsor
- M. Carmen Cabellos Minguez
- Target Recruit Count
- 26
- Registration Number
- NCT01478035
- Locations
- 🇪🇸
Hospital Virgen del Rocio, Sevilla, Spain
🇪🇸Hospital Juan Canalejo, A Coruña, Spain
🇪🇸Fundacio Institut per la Recerca de l'hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Neuroprotection With Phenytoin in Optic Neuritis
- First Posted Date
- 2011-10-13
- Last Posted Date
- 2015-09-09
- Lead Sponsor
- University College, London
- Target Recruit Count
- 92
- Registration Number
- NCT01451593
- Locations
- 🇬🇧
Royal Hallamshire Hospital, Sheffield, United Kingdom
🇬🇧National Hospital for Neurology and Neurosurgery, London, United Kingdom
The Effect of Phenytoin on the Pharmacokinetics of Nevirapine and the Development of Nevirapine Resistance
- Conditions
- Interventions
- First Posted Date
- 2010-08-24
- Last Posted Date
- 2020-12-01
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 66
- Registration Number
- NCT01187719
- Locations
- 🇹🇿
Kilimanjaro Christian Medical Centre, Moshi, Kilimanjaro Region, Tanzania
🇿🇲University Teaching Hospital, Lusaka, Zambia
Bioequivalence Study Of PHENYTOIN Suspension Made By Pfizer, Versus EPAMIN® Made By McNeil LA LLC In Healthy Volunteers Under Fasting Conditions
- First Posted Date
- 2010-05-13
- Last Posted Date
- 2021-01-27
- Target Recruit Count
- 34
- Registration Number
- NCT01122953
- Locations
- 🇲🇽
Pfizer Investigational Site, Mexico, Distrito Federal, Mexico
Double Cord Blood Transplant for Patients With Malignant and Non-malignant Disorders
- Conditions
- Interventions
- First Posted Date
- 2008-12-04
- Last Posted Date
- 2019-03-27
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 1
- Registration Number
- NCT00801931
- Locations
- 🇺🇸
Columbia Presbyterian Medical Center, New York, New York, United States
Antiepileptic Drugs and Vascular Risk Markers
- Conditions
- Interventions
- First Posted Date
- 2008-10-17
- Last Posted Date
- 2017-12-18
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 52
- Registration Number
- NCT00774306
AED/Statin Interaction Study
- First Posted Date
- 2008-03-03
- Last Posted Date
- 2017-08-04
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 119
- Registration Number
- NCT00627575
- Locations
- 🇺🇸
GSK Investigational Site, Buffalo, New York, United States
Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention
- Conditions
- Interventions
- First Posted Date
- 2008-02-20
- Last Posted Date
- 2014-04-07
- Lead Sponsor
- University of Cincinnati
- Target Recruit Count
- 52
- Registration Number
- NCT00618436
- Locations
- 🇺🇸
University of Cincinnati Hospital, Cincinnati, Ohio, United States
Evaluating the Transporter Protein Inhibitor Probenecid In Patients With Epilepsy
- First Posted Date
- 2008-02-08
- Last Posted Date
- 2013-05-14
- Lead Sponsor
- Jim McAuley
- Target Recruit Count
- 8
- Registration Number
- NCT00610532
- Locations
- 🇺🇸
The Ohio State University, Columbus, Ohio, United States
Preventing Epilepsy After Traumatic Brain Injury With Topiramate
- Conditions
- Interventions
- First Posted Date
- 2008-01-23
- Last Posted Date
- 2017-06-27
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 6
- Registration Number
- NCT00598923
Drug Development Updates
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