Gabapentin

Generic Name
Gabapentin
Brand Names
Gralise, Neurontin
Drug Type
Small Molecule
Chemical Formula
C9H17NO2
CAS Number
60142-96-3
Unique Ingredient Identifier
6CW7F3G59X
Background

Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) that was first approved for use in the United States in 1993. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures - today it is also widely used to treat neuropathic pain. Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism making it unlikely to participate in pharmacokinetic drug interactions.. It is structurally and functionally related to another GABA derivative, pregabalin.

Indication

In the United States, gabapentin is officially indicated for the treatment of postherpetic neuralgia in adults and for the adjunctive treatment of partial-onset seizures, with or without secondary generalization, in patients 3 years of age and older. In Europe, gabapentin is indicated for adjunctive therapy in the treatment of partial-onset seizures, with or without secondary generalization, in patients 6 years of age and older and as monotherapy in patients 12 years of age and older. It is also used in adults for the treatment of various types of peripheral neuropathic pain, such as painful diabetic neuropathy.

Associated Conditions
Partial-Onset Seizures, Peripheral Neuropathic Pain, Postherpetic Neuralgia
Associated Therapies
-

Gabapentin as Adjunctive Treatment for Postoperative Pain Control

Phase 1
Completed
Conditions
Interventions
First Posted Date
2015-07-03
Last Posted Date
2017-08-23
Lead Sponsor
Indiana University
Target Recruit Count
13
Registration Number
NCT02490345
Locations
🇺🇸

Eskenazi Hospital, Indianapolis, Indiana, United States

🇺🇸

Eskenazi Health, Indianapolis, Indiana, United States

Treatment of Pendular Nystagmus in OPT

First Posted Date
2015-06-09
Last Posted Date
2018-07-11
Lead Sponsor
Hospices Civils de Lyon
Target Recruit Count
7
Registration Number
NCT02466191
Locations
🇫🇷

Hospices Civils de Lyon, Lyon, France

The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair

First Posted Date
2015-04-17
Last Posted Date
2016-04-11
Lead Sponsor
United States Naval Medical Center, San Diego
Target Recruit Count
100
Registration Number
NCT02419443

Pre-Emptive Analgesia in Ano-Rectal Surgery

First Posted Date
2015-03-30
Last Posted Date
2018-01-16
Lead Sponsor
University of Vermont
Target Recruit Count
90
Registration Number
NCT02402543
Locations
🇺🇸

University of Vermont Medical Center, Burlington, Vermont, United States

🇺🇸

University of Vermont Medical Center Fanny Allen Campus, Colchester, Vermont, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Administration of Pre-Operative Gabapentin to Patients Undergoing Laparoscopy

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-02-09
Last Posted Date
2018-03-12
Lead Sponsor
Milton S. Hershey Medical Center
Target Recruit Count
112
Registration Number
NCT02359110
Locations
🇺🇸

Penn State Hershey Medical Center, Hershey, Pennsylvania, United States

Gabapentin in Reducing the Need for Pain Medication in Patients With Bladder Cancer Undergoing Radical Cystectomy

First Posted Date
2015-02-04
Last Posted Date
2019-06-04
Lead Sponsor
University of Washington
Target Recruit Count
25
Registration Number
NCT02355886
Locations
🇺🇸

Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States

Early Diuresis Following Colorectal Surgery

First Posted Date
2015-01-30
Last Posted Date
2018-05-07
Lead Sponsor
Mayo Clinic
Target Recruit Count
123
Registration Number
NCT02351934
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Gabapentin for Alcohol Relapse Prevention

First Posted Date
2015-01-29
Last Posted Date
2019-11-04
Lead Sponsor
Medical University of South Carolina
Target Recruit Count
96
Registration Number
NCT02349477
Locations
🇺🇸

Medical University of South Carolina, Charleston, South Carolina, United States

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